Objective To explore the effect of early rehabilitation on patients with hand-foot-mouth disease following acute flaccid paralysis. Methods 31 patients with hand-foot-mouth disease following acute flaccid paralysis were in isolation ward of Children's Hospital of Shanxi Province from Aug. 2009 to Oct. 2010. 21 cases of them were given early rehabilitation while 10 cases were divided into control group because their parents refused the rehabilitation intervention. The course was 4 months. Results In the rehabilitation group, 20 cases recovered,1 improved obviously. In the control group, only 1 improved, 9 had no effect. Conclusion Early rehabilitation can improve the motor function of children with hand-foot-mouth disease following acute flaccid paralysis.