OBJECTIVE:To compare the bioequivalence between famotidine chewing tablets and commercial tablets.ME THODS:A single dose of chewing or commercial tablets of famotidine was orally administered in a randomized crossover way in20volunteers and the plasma concentrations of famotidine were determined by HPLC.The pharmacokinetic parameters were calculated with3p97pharmacokinetic program and the bioequivalence was evaluated.RESULTS:The concentration-time curve of two preparations fitted two-compartment model.The peak plasma levels(C max )of chewing and commercial tablet of famotidine were(156.30?105.63)ng/ml and(156.83?99.62)ng/ml respectively.The peak time(T max )were(2.28?0.66)h and(2.28?0.77)h respectively.And AUC (0～24) were(857.55?517.39)and(912.94?638.17)(ng?h)/ml respectively.The relative bioavailability of chewing tablet of famotidine was(93.93?14.49)%.CONCLUSION:The results of two and one-side t tests suggest that the chewing tablet is bioequivalent to the commercial tablet of famotidine.

Objective To establish a new rat model of glycation.Methods D-galactose((150 mg/kg)) was established in rats by intraperitoneal injection for eight weeks.Methods After continuous administration of D-galactose for eight weeks,the level of two-hour blood glucose、activity of aldose reductase、level of fructosamine in serum、the amount of glycohaemoglobin and advanced glycation end-products are all higher than that of control(P

The reactions of 8 lectins with tracheal epithelial goblet cells of Rhesus monkeyshowed the heterogeneity of the cells.The heterogeneity appeared on the differentcomposition of sugar chains in the secretory mucin.The mucin of all goblet cellscontained unequal amount of terminal ?-D-galactose,?-D-mannose and sialic acid aswell as pre-terminal-?-D-galactose and/or ?-D-galactose-(1→3)-N-acetylgalactosa-mine.Only part of goblet cells had variable amount of ?-L-fucose in the secretorymucin.The compositions of sugar chains of the secretory mucin between monkeyand human have significant difference.

Tissue samples from sheep oral epithelium of different age groups were fixed with three different fixatives to observe the ultrastructure of keratohyalin granules. Two conclusions were: 1. There were two types of keratohyalin granules in the sheep oral epithelium. The morphology and ultrastructure of type Ⅰ granules underwent alteration during epithelial development. The shape of granules changed from round to irregular by the combination with tonofilament bundles. Finally, the granules disappeared from several sites of mature oral epithelium. Type Ⅱ granules were round or oval in shape and were surrounded by free ribosomes. They did not have morphologic or ultrastructural changes during epithelial development. They appeared in immature oral epithelium, and constantly presented in mature epithelium. 2. According to the reaction of the two types of granules with the fixatives, it is suggested that the composition of type Ⅰ granules has the property of lipoprotein and the component of type Ⅱ granules possesses the nature of unsaturated lipid in addition to the lipoprotein.

ObjectiveTo identify the reasons of missed diagnosis with ankle sprains by analyzing OAR in order to guide the rational use of OAR.MethodsOutpatient with sprained ankles were recruited from the surgical clinic in Sichuan Luzhou Medical College from Mar.2005 to Mar.2010.OAR was used for clinical diagnosis of ankle sprains.The accuracy of OAR diagnosis was examined within 24 h and at 15 d by X-ray.ResultsIn the 105 cases of ankle sprain,16 cases was diagnosed of fractures by OAR.X-ray results showed I case of missed diagnosis,with the rate of missed diagnosis of 6.2％.While both OAR and X-ray diagnosed 21 cases in 50 patients with sprained foot fractures,with a rate of missed diagnosis of 0.Conclusion OAR diagnosis for ankle sprains and fractures has high success rate although with the possibility of missed diagnosis which needs attention clinically.

AIM　To synthesize derivatives of 2-[substituted phenyl)vinyl] indole and find compounds with biological activities by screening in vitro. METHODS　Twenty-one compounds of 2-[(substituted phenyl)vinyl] indole were synthesized by reduction, oxidation and Witting reaction. MS, 1HNMR and elemental analysis were used to determine the structures of the new compounds. RESULTS　These compounds are new ones. CONCLUSION　Six compounds (3,9,11,13,18 and 20) showed effects on some different receptors, such as alpha2, D2 and H1, and is worth further studying.

Objective To investigate the different effects of clozapine and risperidone on levels of blood glucose in patients with schizophrenia. Method 200 qualified cases selected from psychiatric department were divided into two groups randomly, of which 100 cases accepted the treatment with clozapine and the other 100 cases with risperidone. Blood glucose tests were used before treatment ,4 weeks after treatment and 8 weeks after treatment Results There was significantly higher blood glucose level in clozapine－ treated group than in risperidone－ treated group after 4 or 8 weeks treatment. The number of cases who had elevated blood glucose level (>6.1 mmol/L) in clozapine－ treated group was significantly more than in risperidone－ treated group. Conclusion The glucoregulatory abnormality which leads to glucose elevation in clozapine－ treated patients is greater than in risperidone－ treated patients. Additional motivation to clinical monitor for antipsychotic treatment－ related hyperglycemia is indicated.

Objective To assess the risk of acute myocardial infarction (AMI) and analyze its out‐come by studying the abnormal ECG presentations in AMI patients .Methods The clinical data and ECG presentations of 381 AMI patients were retrospectively analyzed .The abnrmal ECG presentations and the mortalty were comparatively analyzed in AMI patients with multiple lead pathological Q wave ,elevated ST‐segment ,atrial fibrillation (AF) ,bundle branch conduction block ,cardiogenic shock ,and heart failure .Results T he incidence of cardiogenic shock ,heart fail‐ure and the mortality were significantly higher in patients with multiple lead pathological Q wave than in those without multiple lead pathological Q wave (58 .1% vs 21 .4% ,54 .3% vs 23.2% , 40.0% vs 6 .5% ,P<0 .05) and in patients with abnormal presentations such as elevated ST‐seg‐ment and AF than in those without abnormal ECG presentations (P<0 .05 ,P<0 .01) .Conclusion Abnormal ECG presentations ,such as multiple lead pathological Q wave ,can be used as the evi‐dence for the risk and outcome of AMI .

0.05). Conclusion The noise induced by otologic drill did not show the effect that could damage the inner ears and led to the deterioration of the inner ear function.

OBJECTIVE: To study the links between chronic pyelonephritis (CPN) and immune function, and the action mechanism of Yishenkang granule on CPN. METHODS: A total of 120 CPN cases were randomly assigned to Yishenkang granule group, Sanjing tablet group and western medicine group, which were compared with healthy control group. The levels of the peripheral blood T lymphocyte subsets, serum immunoglobulin, complement, secretory IgA in urine and the cell factor IL-2 in CPN cases before and after treatment were detected by monoclonal antibody method, agar diffusion method, radioimmunoassay, radioimmune balancing method and compared with those in healthy control group. RESULTS: In CPN cases compared with healthy control group, the levels of serum immunoglobulin, complement, secretory IgA in urine were significantly lower while the level of cell factor IL-2 were significnatly higher (P