A conducted to determine 1) the effect of high-velocity movement in resistance training with a constant load on the velocity of movement after training and 2) the differences in the effect on muscle hypertrophy according to training velocity. Fourteen of the total subjects (male; n=10, female ; n=7) were placed in the experimental group and agreed to participate in 8 weeks of training sessions (4 times a week) . Five of the 17 subjects were in control a group before the training session. Subjects performed elbow extension and flexion exercise using 50% of one repetition maximum (% 1 RM) load. The exercise session consisted of 6 sets of 10 repetitions and 30s of rest was taken between the sets. The subjects in the experimental group trained their arms using two different protocols ; one was high-velocity movement performed as rapidly as possible (Type R), the other was low-velocity movement performed at a constant and slow velocity (Type S) . Isokinetic torque in elbow flexion was measured at angular velocities of 60, 180, 300 deg/s, respectively, during elbow flexion performed under different constant loads of 0, 30, 50% 1 RM, and the muscle cross-sectional area (CSA) of the elbow flexor was determined before and after training. It was found that Type R did not increased isokinetic torque at 300 deg/s significantly after training. However, the increase in angular velocity of elbow flexion in Type R exercise tended to be higher than in Type S exercise. The increase in CSA [Type S; 11.2%, Type R ; 14.2%] was significantly higher in Type R exercise (p<0.05) . These results suggest that high-velocity movement with a constant load in resistance training might increase the angular velocity of movement in the same mode, but might not produce a change in isokinetic strength, which involves a different mode of muscle contraction. Muscle hypertrophy would be induced to a greater extent by high-velocity movement than by low-velocity movement in resistance training with a constant load.

This study aimed to investigate the influence of aging on muscle thickness in lower limbs, with specific emphasis on the site- and gender-related differences. Subjects were a total of 191 healthy young and elderly persons of both genders : 51 young men (24.2±3.6 yrs), 45 young women (23.1±3.2yrs), 51 elderly males, and 44 elderly females. Lower leg anterior, and lower leg posterior muscle thickness was determined using a brightness mode ultrasonographic apparatus. At all sites except for the thigh posterior, the muscle thickness values were significantly greater in the young than in the elderly groups of both genders, even in terms of the ratio of muscle thickness to body mass^1/3 (Mt/Wt^1/3 ratio), calculated to normalize the morphological differences. The relative difference in muscle thickness between the two age groups was the greatest at the thigh anterior and the least at the thigh posterior in both genders. Between young men and women, the men showed significantly greater muscle thickness and Mt/Wt^1/3 ratio at every site than the women. Between the elderly groups, however, Mt/Wt^1/3 ratios at all sites, except for the thigh anterior, did not show significant gender-related differences. Relative differences in both muscle thickness and Mt/Wt^1/3 ratio between the young men and women were similar among the sites, but between the elderly groups the corresponding values at the thigh anterior were greater than at the other sites. These results indicate that 1) the influence of aging on muscle thickness differs between the muscle groups located in the anterior and posterior sited within the same segment, 2) for women, the age-related loss of muscle thickness at the thigh anterior is relatively greater as compared to those at the other sites of the lower limb.

The influences of age on muscle architectural characteristics, i. e., muscle thickness, pennation angle, fascicle length, were studied in 121 men and 229 women aged 17 to 85 yrs. The subjects were divided into three age groups (younger : 17-39 yrs, middle-aged : 40-59 yrs, elderly : 60-85 yrs) for both genders. Muscle thickness and pennation angle of the vastus lateralis (VL), medial gastrocnemius (MG), and long head of triceps brachii (TB) muscles were measured using B-mode ultraso-nography, and fascicle length was estimated. In all age groups, men had significantly greater relative muscle thickness (to limb length) in VI, and TB than women, but not in MG. Relative muscle thickness of VL was significantly lower in elderly than in younger and middle-aged subjects. Ilowever, the corresponding differences in MG and TB were insignificant. The pennation angle of VL was significantly lower in elderly than in younger and middle-aged subjects, although there were no significant differences in pennation angles of MG and TB among the three groups. These results suggest that the decrease in thickness of vastus lateralis muscle with aging is significant, but not significant for medial gastrocnemius and triceps hrachii muscles.

Walking is the most basic movement in daily life, and is a popular exercise for eloerly individuals to keep their health. However, it is not clear how walking is effective in keeping or increasing the muscle mass and bone intensity of the lower limbs. This study aimed to investigate the relationships between walking steps per day during daily life and either the muscle thickness values of lower leg anterior and posterior or the bone intensity of calcaneus. The subjects were 116 healthy men (n=31) and women (n=85) aged from 60 to 78 yrs, Walking steps per day were deter-mined using a pedometer. Muscle thickness values at the lower leg anterior and posterior sites and the osteo sono assessment index (OSI) of calcaneus were determined using ultrasonographic apparatuses. In women, OSI correlated significantly with walking steps (r=0.265, p<0.05) and the product of walking steps and weight (r=0.369, p<0.05) . In both genders, however, no significant correlations were found between walking steps and muscle thickness values at the two sites. The findings here suggest that increasing the number of walking steps during daily life will improve the intensity of calcaneus for elderly women, but is not effective for inducing hypertrophic change in the muscles located in the lower limbs for elderly individuals of both genders.

This study was aimed to investigate the influences of age and gender on isometric muscle torque and explosive muscle power output with reference to muscle volume. A total of 177 healthy subjects of both genders were divided into four groups according to their age and gender : 46 young men (22.0±3.2yrs), 43 young women (22.7±3.3yrs), 46 elderly men (71.2±4.3yrs) and 42 elderly women (72.7±4.5 yrs) . The maximal voluntary isometric knee extension torque of the right leg (hip and knee angle at 90 degrees) and the power of bilateral leg extension in sitting position were mea sured. The ratios of both torque and power to muscle volume, estimated using ultrasonograph measurement, was calculated (torque/MV and power/MV respectively) . Torque was significantly less among the elderly than among the young for both genders, and among women than among the men for both age groups. Significant age-related differences were evident even in terms of torque/ MV, but the corresponding differences between men and women disappeared. On the other hand, power MV showed significant age- and gender-related differences, and the age-related difference was larger than that for torque MV. These results suggest that age- and gender-related differences in power are more noticeable than differences in torque and that these differences are not simply explained by differences in muscle volume.

The factors influencing ankle range of motion were investigated for 185 middle-aged and elderly subjects (116 women and 69 men, aged 48-86 years) . Each subject was seated with the right knee extended, and the ankle joint was passively dorsiflexed by a dynamometer with torque just tolerable for each subject, to measure the maximal dorsiflexion angle. During passive loading, elongation of muscle fibers in the gastrocnemius and Achilles tendon was determined in vivo by ultrasonography. There was a difference between women and men for the passive dorsiflexion angle (men smaller than women), which negatively correlated with muscle thickness of the posterior portion of the leg determined by ultrasonography. Both in women and men, the passive dorsiflexion angle negatively correlated with age, even after normalizing for maximal voluntary plantar flexion torque. Both elongation of muscle fibers and tendon was related to the passive dorsiflexion angle, and the ratio of tendon elongation to muscle fiber elongation positively correlated with the passive dorsiflexion angle. The active dorsiflexion angle, measured separately with the subject maximally dorsiflexing the ankle with no load, correlated with the passive dorsiflexion angle but not with age, and there was no gender difference. From the results it was suggested 1) that the mobility of the ankle joint is affected by elongation of both muscle fibers and tendon, but with the effect of the tendon being greater than that of muscle fibers, and 2) that muscle mass negatively affects passively-induced joint range of motion. Actively performed joint range of motion would be affected by elongation of the muscle-tendon corn plex and force-generating capability of the ankle. Gender difference in joint range of motion and the aging effect are related to these factors.

Objective: To examine whether quantitative analysis of videofluoroscopic swallowing study (VFSS) images can quantitatively demonstrate the pathophysiology of swallowing disorders in patients.Methods: In total, 71 patients with Parkinson's disease (PD) (mean age 73.4±7.2 years) and 45 patients with sarcopenia (mean age 81.7±4.8 years) were included in the pathological group in this study. The control group comprised 151 individuals without swallowing disorders (mean age 76.0±7.6 years). To examine the distinctive features of swallowing dynamics in the pathological and control groups, a quantitative analysis of VFSS images was conducted. VFSS analysis parameters included measures of bolus movement, such as oral transit time (OTD), pharyngeal transit time (PTD), total transit time (TTD), and stage transition duration (STD). Furthermore, the onset and duration of movements in swallowing organs, including the soft palate, hyoid bone, epiglottis, and upper esophageal sphincter, were measured. VFSS was conducted using a 3-mL liquid bolus.Results: In the PD group, the swallowing disorder features included extended OTD, PTD, TTD, delayed STD, delayed onset times of the soft palate and epiglottis, and shortened movement duration. The sarcopenia group revealed a shortened movement duration in the hyoid bone and epiglottis.Conclusion: The quantitative analysis of VFSS permitted the assessment of swallowing dynamics. The abnormalities observed during swallowing movements in the PD and sarcopenia groups indicated specific pathophysiologies of these conditions, underscoring the utility of VFSS image analysis in understanding swallowing disorders.

Background/Aims: The frequency and details of nonalcoholic fatty liver disease (NAFLD) complications in patients with inflammatory bowel disease (IBD) remain unclear. This study aimed to clarify characteristics of NAFLD in patients with IBD. Methods: We retrospectively identified and enrolled patients with IBD diagnosed with or without NAFLD by undergoing abdominal computed tomography (CT) at our institution between 2005 and 2020. The primary endpoint was the complication rate of NAFLD in patients with IBD. Secondary endpoints were the clinical characteristics of nonobese patients with IBD and comorbid NAFLD and their association with nutritional and inflammatory parameters. Results: Twenty-one (21.9%) of 96 eligible patients with IBD also had NAFLD. In nonobese patients (defined as patients with a body mass index <25 kg/m2), C-reactive protein (CRP; P<0.001) and alanine aminotransferase (P=0.018) levels were higher and the albumin level (P=0.005) and prognostic nutritional index (PNI; P=0.002) values were lower in patients with NAFLD than in those without NAFLD. The PNI value was positively correlated (P<0.001) and the CRP level was negatively correlated (P=0.001) with the hepatosplenic ratio. However, in the NAFLD combined group, PNI (P<0.05) and CRP values (P<0.001) were improved over time after CT imaging by continuing IBD treatment. Conclusions Worsening nutritional and inflammatory status in IBD patients is associated with complications of NAFLD. Diagnosis of NAFLD in IBD patients using CT imaging might be useful not only for early detection of NAFLD but also in assessing the need for therapeutic intervention for IBD.