The rapid spread of COVID-19, which was first reported in Wuhan, China, gave unprecedented impacts to the peoplearound the globe. Since no current established treatments nor medications are available, medical professionals are longing for the effective tools to fight against COVID-19. The true value of Chinese herbal medicine can be seen under such tough circumstances. The effects of Sanyao Sanfang, containing various naturally occurring phytochemicals were reported from the epicenter of COVID-19 in China. The distinctive feature of the Sanyao Sanfang is its ability to strengthen vitality of the body and improved resistance against invasive attacks by viruses and microbes. It also promotes activation of the immune system and its recovery to healthy status. It is obvious that the comprehensive effects of the Sanyao Sanfang do not stem from a single substance. Further studies are warranted for clarification of the mechanism and the role of other raw materials, as well as for the improvement of its formulation, efficacy and safety.