Endometriosis is a common, benign and chronic gynecologic disorder. It is an estrogen dependent disease that can cause pelvic pain, dysmenorrhea and infertility. Because of its high rate of recurrence, medication after surgery is inevitable. GnRH agonist, Danazol, progestogen and oral contraceptive have been conventionally used for the medical treatment of endometriosis. However, systemic side effects of those agents restrict their usage as long-term management. Increasing knowledge about the pathogenesis of endometriosis has introduced new agents which were more targeted and specified for the prevention of recurrence of endometriosis.
Danazol ; Dysmenorrhea ; Endometriosis ; Estrogens ; Female ; Gonadotropin-Releasing Hormone ; Infertility ; Pelvic Pain ; Recurrence

In patients with chronic renal failure, spontaneous tendon rupture may occur due to degenerative changes in the tendon. Transosseous suture and suture anchor are commonly used for repair of quadriceps tendon rupture. But in chronic renal failure patients, the fixation of the repaired tendon is weak due to degenerative changes in the tendon, and decreased bone mineral density results in a relatively high rerupture rate. In this case, spontaneous quadriceps tendon rupture in a patient who has chronic renal failure with dialysis over 10 years was repaired with a newly designed transosseous suture method in order to increase contact of patella base and to reduce the rate of rerupture. Divide ruptured tendon arbitrarily into four layers using the anatomical structure of quadriceps tendon, then pull them out through the three vertical transosseous tunnels and tied them each. This procedure may be considered as another option in the case with high rerupture risk.

Osteoporotic vertebral compression fractures (OVCFs) are the most common osteoporotic fractures in postmenopausal women. One the other hand, they may be misdiagnosed if the deformity is not severe at the time of occurrence. In general, it is treated through absolute bed rest and braces. Vertebroplasty or kyphoplasty is sometimes performed when there is a severe decrease in the height of the vertebral body. In addition, transpedi cular fixation can be performed when there is an accompanying injury to the posterior complex or neurologic symptoms. In this case, the authors performed minimally invasive transpedicular fixation after achieving vertebral body height recovery through postural reduction in OVCF patient who were neglected for one month after the injury. After securing initial stability through screw fixation, complete bony union was achieved more quickly and stably through weekly teriparatide administration. The authors report this case with a review of the relevant literature.

No abstract available.
Antigens, Surface* ; Oncogenes*

PURPOSE: The purpose of this study was to investigate the relationships among depression, somatic symptoms, and activities of daily living of elderly women in urban areas. METHOD: After obtaining participant's consent forms, a one-time, face-to-face, and private interview was conducted with each participant from Sep, 2006 to Jan, 2007 by trained graduate-level students. The questionnaire consisted of K-GDS, PHQ-15, Barthel Index, and Instrumental Activity of Daily Living. The collected data was analyzed with the SPSS/PC 12.0 program, which was used for frequency, percentage, mean, standard deviation, Pearson correlation coefficients, and multiple regression. RESULTS: The major findings of this study were as follows 1) 34.1% of participants belonged to the depression group. 2) There were significant relationships between depression and monthly income, somatic symptoms, ADL, IADL, and number of chronic disease. 3) Significant factors influencing depression were somatic symptoms, ADL, and monthly income. CONCLUSION: The results of this study give useful information for designing interventions and program development for appropriate depression management and care for elderly women.
*Activities of Daily Living ; Aged ; Aged, 80 and over ; *Depression ; Female ; Frail Elderly/*psychology ; Health Status ; Humans ; Interpersonal Relations ; Middle Aged ; Questionnaires ; Social Isolation ; Urban Population

PURPOSE: This study was designed to assess the level of super-leadership and self-leadership, identify correlations among variables and identify the factors influencing organizational commitment of clinical nurses. METHODS: Participants were 217 nurses working in four hospitals located in Seoul and Gyeonggi Province. Data were analyzed using descriptive statistics, independent t-test, one way ANOVA, Scheffé test, Pearson Correlation, and Multiple Regression. RESULTS: The most influential factor for organizational commitment was super-leadership (β=.28, p<.001), followed by education (β=.16, p=.007), the number of unit nurses (β=-.18, p=.003), self-leadership (β=.17, p=.008), and the number of patients being under 10 (β=.12, p=.046). These factors accounted for 23% of the variance in organizational commitment (F=13.46, p<.001). CONCLUSION: The results of this study suggest a need for strategies to improve organizational commitment of nurses by enhancing nurse' self-leadership through nursing managers' super-leadership.
Education ; Gyeonggi-do ; Humans ; Nursing ; Seoul

Although helminth parasites have different life cycles, their hosts share similar immune responses involving Th2 cell-type. Here, we extracted proteins from the larvae of Anisakis simplex complex and Trichinella spiralis to identify common and specific antigens (or allergens) associated with the Th2 immune response. We performed two-dimensional electrophoresis analysis and Matrix-assisted laser desorption ionization–time of flight/time of flight (MALDI-TOF/TOF) experiments. We found 13 potentially immunogenic proteins, which included 5 spots specific to T. spiralis and 8 common to T. spiralis and A. simplex, by tandem mass spectrometry. These molecules were identified structurally as actin, tropomyosin, col cuticle N domain-containing protein, and heat shock proteins. We also identified molecules related to parasite-host immune modulation and interactions. Our results may contribute to reveal potential roles of immunological proteins in parasite-derived immune modulation.

PURPOSE: The effects of fiber alignment and direction of mechanical strain on the ECM generation of human ACL fibroblast were assessed. MATERIALS AND METHODS: The aligned nanofiber was fabricated using electrospinning with a rotating target. The amounts of collagen on aligned and randomly oriented structures were compared. To evaluate the effect of strain direction, 5% uniaxial strain (0.2 Hz) was applied to fibroblasts seeded on parallel aligned, vertically aligned to the strain direction, and randomly oriented nanofiber sheets. The amounts of collagen produced were measured 2 days after halting the strain application. RESULTS: The fibroblasts on the aligned nanofiber were spindle-shaped and oriented in the direction of the fibers. Significantly more collagen (22.5+/-2.7 ug/ngDNA) was synthesized on the aligned nanofiber than the randomly oriented (14.5+/-3.2 ug/ngDNA). And the amounts of collagen produced were increased by 150% and 50% approximately with the longitudinal and perpendicular cyclic strain, respectively. CONCLUSION: The aligned nanofiber scaffold used in this study constitutes a promising base material for tissue-engineered ligament in that it provides a more biomimetic structure, including the preferable mechanical environment.
Biomimetics ; Collagen ; Fibroblasts* ; Humans* ; Ligaments ; Nanofibers*

OBJECTIVES: The objectives of this study were to investigate the agreement between medical history questionnaire data and claims data and to identify the factors that were associated with discrepancies between these data types. METHODS: Data from self-reported questionnaires that assessed an individual's history of hypertension, diabetes mellitus, dyslipidemia, stroke, heart disease, and pulmonary tuberculosis were collected from a general health screening database for 2014. Data for these diseases were collected from a healthcare utilization claims database between 2009 and 2014. Overall agreement, sensitivity, specificity, and kappa values were calculated. Multiple logistic regression analysis was performed to identify factors associated with discrepancies and was adjusted for age, gender, insurance type, insurance contribution, residential area, and comorbidities. RESULTS: Agreement was highest between questionnaire data and claims data based on primary codes up to 1 year before the completion of self-reported questionnaires and was lowest for claims data based on primary and secondary codes up to 5 years before the completion of self-reported questionnaires. When comparing data based on primary codes up to 1 year before the completion of self-reported questionnaires, the overall agreement, sensitivity, specificity, and kappa values ranged from 93.2 to 98.8%, 26.2 to 84.3%, 95.7 to 99.6%, and 0.09 to 0.78, respectively. Agreement was excellent for hypertension and diabetes, fair to good for stroke and heart disease, and poor for pulmonary tuberculosis and dyslipidemia. Women, younger individuals, and employed individuals were most likely to under-report disease. CONCLUSIONS: Detailed patient characteristics that had an impact on information bias were identified through the differing levels of agreement.
Bias (Epidemiology) ; Comorbidity ; Data Accuracy ; Delivery of Health Care ; Diabetes Mellitus ; Dyslipidemias ; Female ; Heart Diseases ; Humans ; Hypertension ; Insurance ; Logistic Models ; Mass Screening ; Sensitivity and Specificity ; Stroke ; Tuberculosis, Pulmonary

PURPOSE: The purpose of this study was to examine the effects of exercise intervention, including dumbbell(weight lifting), walking, and yoga, on the body composition, physiologic factors, body image, and perceived health in the community-dwelling women. METHOD: This study utilized pretest-posttest design with three types of exercise interventions. The types of exercise intervention included dumbbell, walking, and yoga. RESULTS: A total of 136 subjects were included: 49 for dumbbell, 67 for walking, and 20 for yoga. As measures of body composition, BMI, body weight, and body fat rate were significantly improved only after dumbbell intervention(p<.01). Systolic blood pressures were significantly decreased in the groups of dumbbell and walking. Diastolic blood pressure was significantly declined only in the walking group. Vital capacities and body image were improved in all groups(p<.01). However, total cholesterol levels were not improved in all groups(p>.05) and none of the measures for perceived health state were not significantly changed in all groups(p>.05). CONCLUSION: From the findings of this study, it was demonstrated that the effects of exercise interventions were differentiated by their types and variables to be affected. Therefore, future studies that apply the tailored exercise intervention to each age-categorical group are needed.
Adipose Tissue ; Blood Pressure ; Body Composition ; Body Image ; Body Weight ; Cholesterol ; Female ; Humans ; Vital Capacity ; Walking* ; Yoga* ; Surveys and Questionnaires