Although causative factors are not completely defined, carcinogenesis of colorectal cancer is attributed to multiple genetic alterations. The abnormal expressions of oncogenes are regarded to be responsible for the production of malignant phenotype, subsequent invasion and metastasis. From 63 surgically resectable colorectal adenocarcinoma patients, expression of oncogenes in colorectal cancer tissue was evaluated with immunohistochemical staining methods using monoclonal antibodies to products of the oncogenes. To evaluate the possibility of oncogenes as a prognostic factor, we studied the relationship between the expression of oncogenes and the clinicopathologic findings which are well known prognostic factors. Rates of expression in colorectal cancer tissue were 27% for c-myc, 74.6% for c-Ha-ras and 77.8% for c-erbB-2 oncogenes. The positive rate of c-erbB-2 oncogene was higher in the well differentiated group than in the poorly differentiated group. The rates of expression of c-myc and c-Ha-ras oncogenes were significantly correlated each other. Expression of these oncogenes in colorectal cancer were not correlated with the pathologic stage, location of cancer, DNA ploidy pattern and histologic differentiation except between c-erbB-2 and histologic differentiation. In conclusion, there seems to be a possibility that c-erbB-2 could be used as a prognostic factor of colorectal cancer. However, further and more intensive study seems to be required.
Adenocarcinoma ; Antibodies, Monoclonal ; Carcinogenesis ; Colorectal Neoplasms* ; DNA ; Humans ; Neoplasm Metastasis ; Oncogenes* ; Phenotype ; Ploidies

A case of disseminated superficial actinic poroLeratosis affecting 47 years old, house wife, who has been suffering from multiple dark-brownish keratotic papules on the sun-light exposed parts especially face, forearm and dorsa of the both hands with mild itching sensation, is presented. The skin lesions developed about two years ago insidiously and increased size and numberes of the lesion. Her family background suggests autosomal dominant inheritance.
Actins ; Forearm ; Hand ; Humans ; Middle Aged ; Porokeratosis* ; Pruritus ; Sensation ; Skin ; Spouses ; Wills

No abstract available.

OBJECTIVES: To examine emotional and psychological characteristics associated with suicide attempts in depressed patients. METHODS: A sample of 37 inpatients diagnosed with major depressive disorder or depressive disorder NOS was divided into two groups : lifetime suicide attempters(N=15 ; 40.54%), non-attempters(N=22 ; 59.46%). Beck Depression Scale(BDI), Beck Anxiety Scale(BAI), Hamilton Depression Rating Scale(HDRS), Hamilton Anxiety Rating Scale(HARS), and MMPI-2 were used to evaluate symptoms severity and psychological characteristics. RESULTS: Suicide attempters scored higher on the BDI though there were no group differences on the HDRS and on the both anxiety scales. Also they showed higher scores on the F, Fb, Pa, RC1, DEP, HEA, PK, AAS among MMPI-2 subscales. Our findings suggest that suicide attempters among depressed patients undergo more severe subjective distress and difficulties in adjustment than non-attempters. Also they were more hostile to others and showed lower trust. Lastly, they showed more somatic complaints and substance related problems. CONCLUSION: The present study showed that suicide attempters among depressed patients have distinct emotional and psychological characteristics. MMPI-2 would be helpful to assess suicidal risk of depressed patients.
Anxiety ; Depression ; Depressive Disorder ; Depressive Disorder, Major ; Humans ; Inpatients ; Pyrrolidines ; Suicide ; Weights and Measures

No abstract available.

BACKGROUND: The prevalence of cognitive impairment in the elderly has been increasing in recent years with the growing of the aged population. Clinical assessment of cognitive function and mood is very important because cognitive impairment and depression commonly coexist in the elderly. The elderly interacts with the other family members, so cognitive impairment of the elderly influence family function. The objectives of this study were to delineate the factors correlated with cognitive function and to explore the relationship of depression and family function with cognitive function. METHODS: This study was done during 20 day period from July to August, 1996. The subjects were home residents aged 60 years or more living in a subcounty of Kyungpook Province, Korea. The final analysis included 195 subjects(male 95, female 100). The questionnaire included sociodemographic data, MMSE-K(Korean version of Mini Mental State Examination) for evaluation of cognitive function, BDI for evaluation of depression and family APGAR score for evaluation of family function. The results were analyzed by descriptive, comparative and correlative analysis. RESULTS: Mean MMSE-K score was 25.3+/-4.3 with female subjects(23.9+/-4.8) having significantly higher cognitive impairment when compaired to male subjects(26.6+/-3.2)(P<0.001). MMSE-K score was associated with gender, age, year of education(P<0.001), BDI and APGAR score(P<0.05). Religion, smoking and alcohol use were not associated with MMSE-K score. The prevalence of dementia by MMSE-K was 9.7% in definite dementia (MMSE-K<_19) and 23.1% with questionable dementia(20<_MMSE-K<_23). In male, the prevalence was 1.1% and 20.0% respectively. In female, the prevalence was 18.0% and 26% respectively, indicating difference between male and female subjects(P<0.001). CONCLUSIONS: In the elderly, female gender, older age and lower educational level were associated with cognitive function impairment. There was a positive correlation between cognitive function and family function. The group with impaired cognitive function had more depression than the normal group.
Aged* ; Apgar Score ; Dementia ; Depression* ; Female ; Gyeongsangbuk-do ; Humans ; Korea ; Male ; Prevalence ; Smoke ; Smoking ; Surveys and Questionnaires

BACKGROUND: Combined spinal-epidural anesthesia (CSEA) has gained an increasing interest as it combines the reliability of a spinal block and the flexibility of an epidural block. This study was designed to determine the distance from skin to epidural space (S-EP) and the distance from epidural space to subarachnoid space (E-SA) in obstetric parturient and whether weight, height, BMI (body mass index) and PI (ponderal index) might influence S-EP and E-SA. METHODS: Sixty obstetric patients undergoing elective cesarean section during CSEA in L3-4 level were partitioned into group I (with dural click), group II (no dural click) and in each group, weight (prepregnancy, pregnancy), height, BMI and PI were measured. Measurements of S-EP and E-SA were made. The Pearson correlation was used to investigate relationships between S-EP, E-SA and patient characteristics (height, weight, BMI, PI). RESULTS: S-EP was 4.39+/-0.49 cm and E-SA was 8.23+/-2.05 mm (7.99+/-2.07 mm in group I, 8.78+/-1.94 mm in group II). S-EP was related to weight, BMI and PI except height. E-SA was related to pregnancy BMI and pregnancy PI in group I. No correlation was found between E-SA and other variables in group II. CONCLUSIONS: E-SA in obstetric parturients was related to obesity and has been found to be somewhat larger and more variable due to the segmented and discontinous nature of epidural space.
Anesthesia* ; Cesarean Section* ; Epidural Space* ; Female ; Humans ; Obesity ; Pliability ; Pregnancy ; Skin ; Subarachnoid Space*

No abstract available.
Family Practice* ; Humans ; Primary Health Care*

During the period from 1988 to 1993, 86 cases of varicose vein in lower extremity were treated at Department of General surgery, Chonnam University Hospital. 36 outpatients were treated by compression sclerotherapy and 50 inpatients by surgery. The results were as follows ; 1) The prevalent age group were 4th and 5th decade. 2) The predisposing factors of varicose vein were profession requiring long time standing (48.8%), pregnancy (14%) and hereditary (4.7%), in order. 3) Varicose veins were located in the greater saphenous system (50%), the lesser saphenous system (46.5%) and both (3.5%). 4) The cardinal symptoms and signs were tortuosity of veins(100%), aching pain(29.1%), leg heaviness(14.0%), walking discomfort(8.1%) and leg edema(7.0%). 5) The used sclerosing agent was 5% ethanolamine oleate in compression sclerotherapy group and the operation method in surgery group was high ligation and vein stripping. 44.4% of patients treated initially by compression sclerotherapy and 80% of those treated surgically were given no further treatment. 6) The postoperative complications in surgery group were recurred or remained varicosity (5 cases), hematoma(2 cases), recurrent ulcer(1 case), wound dehiscence(1 case) and thrombophlebitis(1 case). 7) The complications in sclerotherapy group were recurred or remained varicosity(10 cases), induration and bluish discoloration(1 case).
Causality ; Ethanolamine ; Humans ; Inpatients ; Jeollanam-do ; Leg ; Ligation ; Lower Extremity* ; Oleic Acid ; Outpatients ; Postoperative Complications ; Pregnancy ; Sclerotherapy ; Varicose Veins* ; Veins ; Walking ; Wounds and Injuries

PURPOSES: To evaluate the effect of hormone replacement therapy(HRT) on serum insulin-like growth factors(IGFs) levels and to investigate if changes in serum IGFs reflect changes in BMD after HRT in postmenopausal women. MATERIAL & METHODS: IGF-I and IGF-II were measured by radioimmunoassay after Bio-spin P-10 seperation in sera obtained every 3 months from postmenopausal women who was taking premarin alone (premarin group; n=17) or premarin-medroxyprogesterone acetate(MPA group; n=42) for 1 year. Also, bone mineral density(BMD) were determined before and 1 year after HRT by dual energy X-ray absorptiometry(DEXA). All statistics were performed by Paired t-test, student's t-test, repeated measures ANOVA test, Pearson's coefficient. RESULTS: HRT increased BMD of the lumbar spine and proximal femur in both premarin group and MPA group, but any difference in degreee of increase in BMD was not noted between premarin group and MPA group. Compared with pretreatment levels, serum IGF-I levels decreased at 3, 6 and 12 months after therapy only in latter group whereas serum IGF-II levels increased at 6 and 12 months after HRT in both groups. Changes in serum IGF-I and IGF-II levels during therapy did not show any difference by the bone response to HRT. Changes in serum IGF-II levels after HRT did not correlated with the 1 year changes in BMD at any skeletal sites studied, but changes in serum IGF-I levels from pretreatment to 6 months after HRT was negatively correlated with change in BMD of Ward's triangle. CONCLUSION: HRT influences serum IGF levels in postmenopausal women and changes in serum IGF-I levels may predict the changes in BMD of Ward's triangle after HRT.
Bone Density* ; Estrogens, Conjugated (USP) ; Female ; Femur ; Hormone Replacement Therapy* ; Humans ; Insulin-Like Growth Factor I ; Insulin-Like Growth Factor II ; Postmenopause ; Radioimmunoassay ; Spine