Responses of mouse lymphocytes to the soybean paste fermented by Korean traditional fashion was examined to clarify its effects in cytokine production in vitro. A fraction of the soybean paste (KFSP-100) was prepared by precipitation with ammonium sulfate and by filtration through ultrafiltration membrane. KFSP-100 were added into cultures of fresh mouse splenic cells in vitro. KFSP-100 significantly enhanced the amount of IL-6 and TNF-a produced by macrophages and IL-6 and IFN-r produced by lymphocytes. Production of IL-12 by macrophages was not much affected by KFSP-100 treatments. The most noticeable finding was the fact that lymphocytes treated with KFSP-100 proliferated to an exceeding numbers (more than 10 times to the control) in 72 hours. The KFSP-100-induced proliferative response was specific to B cells since almost all of the KFSP-100-induced cells in the cultures of splenic cells were B cells. Furthermore, such a proliferative responses were equally observed only in cultures of purified B cells but not in cultures of T cells. In thermostability test, the biologically active components of the KFSP-100 is assumed to be either linear protein or glycoprotein. KFSP-100 did not induce agglutination of lymphocytes demonstrated by lectins in the same cells. These observations suggest that KFSP-100 may be a novel mitogen for B lymphocytes. The component (s) responsible for the B cell proliferation in KFSP-100 might be a factor gained by natural fermentation. None of the fractions of not fermented soybean paste prepared by the same methods demonstrate the same effect.
Agglutination ; Ammonium Sulfate ; Animals ; B-Lymphocytes ; Cell Proliferation ; Fermentation ; Filtration ; Glycoproteins ; Immunologic Factors* ; Interleukin-12 ; Interleukin-6 ; Lectins ; Lymphocytes ; Macrophages ; Membranes ; Mice ; Soybeans* ; T-Lymphocytes ; Ultrafiltration

Spinal muscular atrophy (SMA) is a neuromuscular disease that requires multidisciplinary medical care, including rehabilitation management. The emergence of a genetic therapy-based approach for SMA has markedly changed the disease course.Nonetheless, currently, updated physical therapy and rehabilitation are warranted for individuals with SMA in the era of gene therapy. In this review, we discuss the physical therapy and rehabilitation strategies currently performed for people with SMA, such as positioning and bracing, supported standing, management of musculoskeletal deformities, stretching, physical exercise training like aerobics and strengthening exercises, assistive devices, pulmonary rehabilitation, and dysphagia treatment.

PURPOSE: Despite radical lymph node dissection and combined resection, the operative result of progressive gastric cancer remains unsatisfactory. The prognosis of gastric cancer has not been improved. In case of recurred gastric cancer, the problem is low curative resection rate. We tried to study the pattem of recurrence after curative resection for gastric cancer. MATERIALS AND METHODS: We had retrospectively analyzed the recurrence pattern of 191 patients who recurred after curative resection of gastric cancer. We analyzed the interval between operation and recurrence, primary tumor location, tumor histologic type, Borrmann's type, pathologic stage, DNA ploidy pattem and lymph node metastasis. RESULT: The number of recurred gastric cancer patients was 191. The M: F ratio was 2.03: 1. Seven cases were early gastric cancer. The interval between operation and recurrence was from 1 month to 130 months. The early recurrence within 24 months was found in 147 patients (77.0%), the intermediate recurrence from 25 months to 60 months was found in 38 patients (19.9%), the late reeurrence after 60 months was found in 6 patients (3.1%). The pattems of recurrence were as follows: loco-regional recurience, including lymph node and site of anastomosis, was found in 51 cases, liver metastasis in 37 cases, peritoneal metastasis in 74 cases, extraperitoneal metastasis in 29 cases including Virchows node. In undifferentiated cancer, peritoneal metastasis was higher than in other histologic types (p<0.05). 59 cases was found in stage IV, 47 cases in stage IIIb, 43 cases in stage IIIa, 31 cases in stage II, 8 cases in stage Ib, and 3 cases in stage Ia. We found peritoneal metastasis was very high in stage IIIb. The 5-year survival was better in loco-regional group than that of other patterns of recurrence. CONCLUSION: Recurrence after operation was found within 24 months, that in most of patients, so the follow up is very important in this period and the recurred pattem after curative resection for gastric cancer was related with cell differentiation of primary tumor and stage. In local recurrence, the survival rate was higher than the other pattern of recurrence.
Cell Differentiation ; DNA ; Follow-Up Studies ; Humans ; Liver ; Lymph Node Excision ; Lymph Nodes ; Neoplasm Metastasis ; Ploidies ; Prognosis ; Recurrence* ; Retrospective Studies ; Stomach Neoplasms* ; Survival Rate

OBJECTIVE: The aim of this study was to determine factors affecting the long-term survival of subjects with aortic aneurysm (AA). METHODS: We included 294 Korean patients aged ≥30 years who were hospitalized from 1994 through 2004. Diagnosis was confirmed in 267A subjects (75.8% with abdominal only AA (AAA) and 24.2% with thoracic AA (TAA)) by computed tomography angiography in Samsung Medical Center, Seoul, Korea. AA repair direct operation or percutaneous endovascular AA repair (Revascularized group) was performed in 60.3% of the total patients. Death data were obtained from all participants between 1994 and 2009. RESULTS: The mean age of AA subjects was 68.7 (±8.1) years. The proportion of males was 82%. Five- and 10-year survival rates were 89.8% and 82.6%, respectively. The 5- and 10-year survival rates were 92.3% and 84.9% in revascularized group and 86.4% and 79.5% in non-revascularized group, respectively. Adjusted hazard ratios were 1.11 {95% confidence interval (CI) 1.04-1.21} in ages and 3.07 (95% CI 1.26-7.90) in smoking for AA. CONCLUSIONS: Age and smoking contributed to death in Korean AA patients. In addition, the 10-year survival rate for AA patients in Korea was over 80%.
Angiography ; Aortic Aneurysm* ; Diagnosis ; Humans ; Korea ; Male ; Seoul ; Smoke ; Smoking ; Survival Rate*

Tumor lysis syndrome (TLS) is a metabolic derangement that may be seen after the initial treatment of cancer and usually occurs in patients with bulky, rapidly proliferating, or treatment-responsive tumors such as acute leukemia or Burkitt lymphoma. However, it is rare in the treatment of the solid tumor, especially osteosarcoma. An 11-year-old girl was admitted with a 3-months history of severe right leg pain. She was diagnosed as osteosarcoma and was treated with cisplatin and adriamycin. Three days after treatment, the values of potassium, phosphorus, uric acid were 6.4 mEq/L, 5.6 mg/dL and 8.9 mg/dL, respectively. At the same time, the value of calcium was 6.2 mg/dL. Although she was treated with proper conservative treatment including dialysis, she had significant complications such as renal failure, heart failure, hypoxic brain damage. We report a case of TLS in a girl with huge osteosarcoma.
Burkitt Lymphoma ; Calcium ; Child ; Cisplatin ; Dialysis ; Doxorubicin ; Heart Failure ; Humans ; Hypoxia, Brain ; Leg ; Leukemia ; Osteosarcoma ; Phosphorus ; Potassium ; Renal Insufficiency ; Tumor Lysis Syndrome ; Uric Acid

Purpose: Few studies have assessed the prevalence of temporomandibular disorders (TMD) in the Korean population. Methods: We used cohort data from the Korean National Health Insurance Service between 2012 and 2020. The data consisted of main diagnoses related to TMD (International Classification of Diseases 10th Revision [ICD-10] code: K07.6 and K07.6x). The age-standardized prevalence of TMD was calculated using the estimated Korean population in 2020 as a reference. Results: The age-standardized prevalence of TMD increased from 604 persons per 100,000 persons in 2012 to 869 persons in 2020. In 2020, the overall age-standardized prevalence was 1,355 persons in the 10 to 19 years age group, 1,809 persons in the 20 to 29 years age group, and 979 persons in the 30 to 39 years age group. The age-standardized prevalence was approximately 1.5 times higher in females than in males (698 persons in males vs. 1,040 persons in females). Among the specific TMD subtypes, the age-standardized prevalence of internal derangement of the temporomandibular joint and pain in the temporomandibular joint, not classified elsewhere, was higher than that of other specific TMDs. Conclusion The overall age-standardized prevalence of TMD was higher in the 10s, 20s, and 30s age groups and in females between 2012 and 2020. The age-standardized prevalence of internal derangement of temporomandibular joint was the highest among specific TMD subtypes.

Objective: To evaluate the association between atopic dermatitis (AD) and suicidal behaviors in adolescent defectors among residents who escaped from North Korean (adolescent defectors, n=423) and adolescents with South Korean parents (Korean adolescents, n=540,265). Methods: The study used data from the Korea Youth Risk Behavior Survey conducted from 2011 to 2019. Differences in general characteristics, health behaviors, suicidal ideation, suicide plans, suicide attempts, and AD between adolescent defectors and Korean adolescents were examined. Multiple logistic regression analysis was used to determine the association between AD and suicidal behaviors. Results: The adolescent defectors group had lower AD (16.3% vs. 24.2%), poorer subjective health (10% vs. 6%), smoked more (47% vs. 18%), drank more (60% vs. 43%), lived with family less frequently (56% vs. 96%), and were more than twice as likely to have depression (42% vs. 27%), suicidal ideation (30% vs. 14%), a suicide plan (23% vs. 5%), or have made a prior suicide attempt (19% vs. 3%) compared with the Korean adolescent group (p<0.001). The adjusted odds ratio for the adolescent defectors group compared to the Korean adolescent group was 1.66 for suicidal ideation, 3.59 for suicide plans, and 4.34 for suicide attempts (p<0.001). AD was found to be associated with suicide plans and attempts in adolescent defectors and associated with suicidal ideation in Korean adolescents. Conclusion AD was significantly associated with suicide plans and suicidal attempts among adolescent defectors and suicidal ideation in Korean adolescents, based on a random sample of middle- and high-school students.

Purpose: Few studies have assessed the prevalence of temporomandibular disorders (TMD) in the Korean population. Methods: We used cohort data from the Korean National Health Insurance Service between 2012 and 2020. The data consisted of main diagnoses related to TMD (International Classification of Diseases 10th Revision [ICD-10] code: K07.6 and K07.6x). The age-standardized prevalence of TMD was calculated using the estimated Korean population in 2020 as a reference. Results: The age-standardized prevalence of TMD increased from 604 persons per 100,000 persons in 2012 to 869 persons in 2020. In 2020, the overall age-standardized prevalence was 1,355 persons in the 10 to 19 years age group, 1,809 persons in the 20 to 29 years age group, and 979 persons in the 30 to 39 years age group. The age-standardized prevalence was approximately 1.5 times higher in females than in males (698 persons in males vs. 1,040 persons in females). Among the specific TMD subtypes, the age-standardized prevalence of internal derangement of the temporomandibular joint and pain in the temporomandibular joint, not classified elsewhere, was higher than that of other specific TMDs. Conclusion The overall age-standardized prevalence of TMD was higher in the 10s, 20s, and 30s age groups and in females between 2012 and 2020. The age-standardized prevalence of internal derangement of temporomandibular joint was the highest among specific TMD subtypes.

Purpose: Few studies have assessed the prevalence of temporomandibular disorders (TMD) in the Korean population. Methods: We used cohort data from the Korean National Health Insurance Service between 2012 and 2020. The data consisted of main diagnoses related to TMD (International Classification of Diseases 10th Revision [ICD-10] code: K07.6 and K07.6x). The age-standardized prevalence of TMD was calculated using the estimated Korean population in 2020 as a reference. Results: The age-standardized prevalence of TMD increased from 604 persons per 100,000 persons in 2012 to 869 persons in 2020. In 2020, the overall age-standardized prevalence was 1,355 persons in the 10 to 19 years age group, 1,809 persons in the 20 to 29 years age group, and 979 persons in the 30 to 39 years age group. The age-standardized prevalence was approximately 1.5 times higher in females than in males (698 persons in males vs. 1,040 persons in females). Among the specific TMD subtypes, the age-standardized prevalence of internal derangement of the temporomandibular joint and pain in the temporomandibular joint, not classified elsewhere, was higher than that of other specific TMDs. Conclusion The overall age-standardized prevalence of TMD was higher in the 10s, 20s, and 30s age groups and in females between 2012 and 2020. The age-standardized prevalence of internal derangement of temporomandibular joint was the highest among specific TMD subtypes.

Purpose: Few studies have assessed the prevalence of temporomandibular disorders (TMD) in the Korean population. Methods: We used cohort data from the Korean National Health Insurance Service between 2012 and 2020. The data consisted of main diagnoses related to TMD (International Classification of Diseases 10th Revision [ICD-10] code: K07.6 and K07.6x). The age-standardized prevalence of TMD was calculated using the estimated Korean population in 2020 as a reference. Results: The age-standardized prevalence of TMD increased from 604 persons per 100,000 persons in 2012 to 869 persons in 2020. In 2020, the overall age-standardized prevalence was 1,355 persons in the 10 to 19 years age group, 1,809 persons in the 20 to 29 years age group, and 979 persons in the 30 to 39 years age group. The age-standardized prevalence was approximately 1.5 times higher in females than in males (698 persons in males vs. 1,040 persons in females). Among the specific TMD subtypes, the age-standardized prevalence of internal derangement of the temporomandibular joint and pain in the temporomandibular joint, not classified elsewhere, was higher than that of other specific TMDs. Conclusion The overall age-standardized prevalence of TMD was higher in the 10s, 20s, and 30s age groups and in females between 2012 and 2020. The age-standardized prevalence of internal derangement of temporomandibular joint was the highest among specific TMD subtypes.