1.Primary Epithelial Ovarian Carcinoma with Gastric Metastasis Mimic Gastrointestinal Stromal Tumor.
Woo Dae KANG ; Cheol Hong KIM ; Moon Kyoung CHO ; Jong Woon KIM ; Ji Shin LEE ; Seong Yeob RYU ; Yoon Ha KIM ; Ho Sun CHOI ; Seok Mo KIM
Cancer Research and Treatment 2008;40(2):93-96
Epithelial ovarian carcinoma rarely metastasizes to the parenchyma of the stomach. A 55-years-old woman presented with epigastric pain and a feeling of fullness for one month. A subsequent contrast-enhanced CT scan demonstrated a 4.5 x 4 cm submucosal mass with focal ulceration in the gastric antrum, and this finding was suggestive of GIST. After gastric antrectomy, the final pathology showed metastatic gastric tumor from a primary ovarian serous carcinoma. Because epithelial ovarian carcinoma is usually spread along the peritoneal surface, stomach involvement is rare. Furthermore, transmural gastric metastasis is very rare in a patient with primary ovarian carcinoma. Until now, there has been no reported case of stomach involvement at presentation in a patient with primary ovarian carcinoma. We present here a case of ovarian carcinoma with gastric metastasis that mimicked GIST.
Female
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Gastrointestinal Stromal Tumors
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Humans
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Hydrazines
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Neoplasm Metastasis
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Pyloric Antrum
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Stomach
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Ulcer
2.The Effect of Morphine on REST Expression in Human Neuroblastoma NMB Cells.
Do Kyung KIM ; Chun Sung KIM ; Heung Joong KIM ; Joong Ki KOOK ; Seung Hee KIM ; Baek Hee LEE ; Yun Ho LEE ; Shin Yeob MO ; Horace H LOH
International Journal of Oral Biology 2010;35(2):69-74
The mu opioid receptor (MOR) has been regarded as the main site of interaction with analgesics in major clinical use, particularly morphine. The repressor element-1 silencing transcription factor (REST) functions as a transcriptional repressor of neuronal genes in non-neuronal cells. However, it is expressed in certain mature neurons, suggesting that it may have complex and novel roles. In addition, the interactions between MOR and REST and their functions remain unclear. In this study, we examined the effects of morphine on the expression of REST mRNA and protein in human neuroblastoma NMB cells to investigate the roles of REST induced by MOR activation in neuronal cells. To determine the effects of morphine on REST expression, we performed RT-PCR, real-time quantitative RT-PCR, western blot analysis and radioligand binding assays in NMB cells. By RT-PCR and real-time quantitative RT-PCR, the expression of REST was found to be unchanged by either the MOR agonist morphine or the MOR specific antagonist CTOP. By western blot, morphine was shown to significantly inhibit the expression of REST, but this suppression was completely blocked by treatment with CTOP. In the radioligand binding assay, the overexpression of REST led to an increased opioid ligand binding activity of endogenous MOR in the NMB cells. These results together suggest that morphine inhibits the expression of REST in human neuroblastoma cells through a post-transcriptional regulatory mechanism mediated through MOR.
Analgesics
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Blotting, Western
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Humans
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Morphine
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Neuroblastoma
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Neurons
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Receptors, Opioid, mu
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RNA, Messenger
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Somatostatin
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Transcription Factors
3.Spatial Distribution and Prognostic Implications of Tumor-Infiltrating FoxP3- CD4+ T Cells in Biliary Tract Cancer
Hyung-Don KIM ; Jwa Hoon KIM ; Yeon-Mi RYU ; Danbee KIM ; Sunmin LEE ; Jaehoon SHIN ; Seung-Mo HONG ; Ki-Hun KIM ; Dong‐Hwan JUNG ; Gi‐Won SONG ; Dae Wook HWANG ; Jae Hoon LEE ; Ki Byung SONG ; Baek-Yeol RYOO ; Jae Ho JEONG ; Kyu-pyo KIM ; Sang-Yeob KIM ; Changhoon YOO
Cancer Research and Treatment 2021;53(1):162-171
Purpose:
The clinical implications of tumor-infiltrating T cell subsets and their spatial distribution in biliary tract cancer (BTC) patients treated with gemcitabine plus cisplatin were investigated.
Materials and Methods:
A total of 52 BTC patients treated with palliative gemcitabine plus cisplatin were included. Multiplexed immunohistochemistry was performed on tumor tissues, and immune infiltrates were separately analyzed for the stroma, tumor margin, and tumor core.
Results:
The density of CD8+ T cells, FoxP3- CD4+ helper T cells, and FoxP3+ CD4+ regulatory T cells was significantly higher in the tumor margin than in the stroma and tumor core. The density of LAG3- or TIM3-expressing CD8+ T cell and FoxP3- CD4+ helper T cell infiltrates was also higher in the tumor margin. In extrahepatic cholangiocarcinoma, there was a higher density of T cell subsets in the tumor core and regulatory T cells in all regions. A high density of FoxP3- CD4+ helper T cells in the tumor margin showed a trend toward better progression-free survival (PFS) (p=0.092) and significantly better overall survival (OS) (p=0.012). In multivariate analyses, a high density of FoxP3- CD4+ helper T cells in the tumor margin was independently associated with favorable PFS and OS.
Conclusion
The tumor margin is the major site for the active infiltration of T cell subsets with higher levels of LAG3 and TIM3 expression in BTC. The density of tumor margin-infiltrating FoxP3- CD4+ helper T cells may be associated with clinical outcomes in BTC patients treated with gemcitabine plus cisplatin.
4.Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology
Jung Hee KIM ; Hyun Wook CHAE ; Sang Ouk CHIN ; Cheol Ryong KU ; Kyeong Hye PARK ; Dong Jun LIM ; Kwang Joon KIM ; Jung Soo LIM ; Gyuri KIM ; Yun Mi CHOI ; Seong Hee AHN ; Min Ji JEON ; Yul HWANGBO ; Ju Hee LEE ; Bu Kyung KIM ; Yong Jun CHOI ; Kyung Ae LEE ; Seong-Su MOON ; Hwa Young AHN ; Hoon Sung CHOI ; Sang Mo HONG ; Dong Yeob SHIN ; Ji A SEO ; Se Hwa KIM ; Seungjoon OH ; Sung Hoon YU ; Byung Joon KIM ; Choong Ho SHIN ; Sung-Woon KIM ; Chong Hwa KIM ; Eun Jig LEE
Endocrinology and Metabolism 2020;35(2):272-287
Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.