The routine closed patch tests were performe0 with 41 kinds of domestic soaps, detergents, cosm etics and topical medicaments (incIuding a adhesive plaster) on the intact skin of the back of 100 adult males without any dermatoses, to evaluate their side effects on the skin. 1, None of the materials showed no positive reaction, 2, The over all positive reactions were observed in 21.l% of my subjects, including a 1+reacti ons in,l6,4% and a 2+or 3, In 4.7% 3, In 12 kinds of soaps, Positive reaction wer observed in 19-33% positive of my subjects (average Z7.8%) 4, In 4 kinds of detergents, positive reations were observed in 6-19% of my subjects (average 9,7%), in which the highest reaction rate revealed was IVonderful of Dongsan fats and oils co.. 5. The positive reactiors in 3 kinds of toothpastes were observed in 37-61% of my subjects (average 50.7%). 6. The positive reactions to the adhesive plaster were observed in 25% of my subjects. Arnong 17 kinds of topial medicaments, positive reaction rates above 10 shown were Aroos oirtment of Sarn-A phaxmaceutical co. (49%), PM spirit of Kyungnam pharmaceutical co. (16%), Periio ointment of Namgang pharmaceutical co. (13%), Badional-Gel of Hanil pharm-aceutcal co. (10%) and Antiphlamine of Yuhan corporation (10%). 8. In 4 kinds of cosmetic creams, all showed higher positive reaction rates, i.e, "Masan Joongang cream of Yeinvonlang No I, 41%;No.2, 35%;N0.3, 32% and E.mong cream" of Daido phanna-ceutical co,44%.
Adhesives ; Adult ; Detergents ; Fats ; Gyeongsangnam-do ; Humans ; Male ; Oils ; Patch Tests ; Skin ; Skin Diseases ; Soaps* ; Toothpastes

A typical case of lichen amyloidosis is reported. This case is considered to be the first one in Korea. Intralesional injection of prednisolone proved to be effective in this case. The etiologic and therapeutic aspects of this disease are discussed.
Amyloidosis* ; Injections, Intralesional ; Korea ; Lichens* ; Prednisolone

No abstract available.
Mast Cells* ; Skin Diseases*

Fifty-one cases of various warts were treated with 1-cbloro-2,4-dmitrobenzene (DNCB), and divided these warts into two groups by the method of treatment. The first group was treated by challenge on normal skin a,fter sensitization and the second group was treated by challenge on wart lesion after sensitization. The number of first group was 27 consisted of 13 of verruca vulgaris, 12 of verruca plana and 2 of condyloma acuminatum. The number of second group was 24 consisted of 10 of verruca vulgaris, 11 of verruca plana and R of verruca plantaris. The results are summarized as follows; 1. Thirty-one of all 51 cases (60. 7%) were cured. 2. Fifteen of 27 cases (55.5%) were cured in first group. 3. Sixteen of 24 cases (66. 6%) were cured in second group. 4. All 3 cases of verruca planaris were cured in second group. 5. Eight cases were cured only by sensitization and consisted of 6 of verruca plana and of verruca vulgaris. 6. There was no significant difference in cure rates of warts between the group within 2 years of duration and the group over 2 years of duration. 7. There were no severe adverse reactions.
Dinitrochlorobenzene* ; Immunotherapy* ; Skin ; Warts*

This study was undertaken to investigate the response of non-immunologic contact urticaria(NICU) test before and after ingestion of cyclo-oxygenase inhibitors such as naproxene, ibuprofen and mefenamic acid. Forty patients who showed positive reaction to 5% benzoic acid (BA) in petrolatum by 20 minutes closed patch test were chosen and divided into 3 groups. Group I was consisted of 13 patients who were taken naproxene 250mg bid, group II, 14 patients, taken ibuprofen 600mg bid, and group III, 13 patients, taken mefenamic acid 500mg bid. All the patients were tested with 5%, 2.5%, 1%, 0.5% and 0.1% BA in petrolatum using Finn chamber on Scanpor tape on the right arm before medication and next day on the left arm after medication of each day. Mefenamic acid did not show any significant differences before and after ingestion of drug. Naproxene reduced reaction about half of patients. Ibuprofen reduced reaction in almost all patients and blocked reaction completely in 9 of 13 patients. This results suggested that there was no correlation between blocking effect to BA induced contact urticaria and so called anti-inflammatory potencies of naproxene and ibuprofen, and that NICU by BA is partly mediated by prostaglandins(PG) or mediated by other mediators, which were potentiated by PG, except histamin.
Arm ; Benzoic Acid ; Cyclooxygenase Inhibitors ; Eating ; Humans ; Ibuprofen ; Mefenamic Acid ; Naproxen ; Patch Tests ; Petrolatum ; Urticaria*

No abstract available.
Mast Cells* ; Skin Diseases*

A clinical study was made on 148 cases of cutaneous malignant tumors that visited the Department of Dermatology at Seoul National University Hospital during a 11-year period from 1973 to 1983. The results were summarized as follows: 1) The incidence of cutaneous malignant tumors in the total number of outpatients visiting the Department of Derrnatology was 0. 025g. 2) There were 90 cases of male (60. 8p,) and 58 cases of female (39. 2g). The ratio of male to female was l. 55: l. Among the 148 cases of cutaneous malignant tumors, the most frequently observed type was basal cell carcinoma, 58 cases (3j.2 p:). The next most frequent types were squamous cell carcinoma, 42 cases(28. 4g) and malignant melanoma, ]1 cases (7. 4g). We described the clinical characteristics of the patients with basal cell carcinoma, squamous cell carcinoma and malignant melanoma that have been observed.
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Dermatology ; Female ; Humans ; Incidence ; Male ; Melanoma ; Outpatients ; Seoul

The serologic testa for syphilis including VDRL and FTA-abs tests have been carried out in adult VISA applicants for emigration and bIood donors from February, 1977 to May, 1978. The results are summarized as followa: l. In 3,393 VISA applicants the reactive rate af VDRL test was 2.9%, and th biologic false positive rate of VDRL test was 5.1% using the FTA-abs test as the atandared. 2. VDRL test showed a positive rate of 2.3% in 6,220 blood donors. 3. The quantitative test of VDRL resulted in low titer belaw 1:4 in 93.9% of VDRL reactive VISA applicants. From the results it is clear that the prevalence of syphilis is grariually increasing recently compared to the late 1960s and early 1970s.
Adult ; Blood Donors ; Emigration and Immigration ; Fluorescent Treponemal Antibody-Absorption Test ; Humans ; Prevalence ; Skin Diseases* ; Syphilis ; Tissue Donors ; Zinc*

Contact Dermatitis due to cosmetics is also common in Korea. as in other developed countries. However. detection of the causative antigens is in a difficult situation due to many reasons. We have routinely patch tested with Japanese cosmetic series patch test allergens, Types 17 and 18 in addition to Hollister standard battery and patients own cosmetics to 4Q cases of suspected cosmetic contact dermatitis who have visited our Environmental and Occupational Clinic during the past one year. The study result was as follows. Total 55% ositive reaction related to cosmetics was observed in 4p patch tested patients. 2 The most frequently observed antigens were hydroxycitronellal, benzyl saliylate and cinnamic alcohol.
Allergens ; Asian Continental Ancestry Group ; Dermatitis, Contact* ; Developed Countries ; Humans ; Korea ; Patch Tests*

Acromelanosis Progressiva which was described by Mishirna et al. In 1962 is a very rare pigmentary disorder and it seems that this is the first case reporting in Korean literature. The patient we observed was 11 years old girl having dark brown macules on the dorsa of her hands and feet, forearms, lower legs and face. These pigmented macules at first appeared on the dorsal surfaces of her fingers and toes when her age of 7. Thereafter these macules spread somewhat progressively to the proximal portions of the extremities and recently those have been spread upon her forearms and lower legs. The same pigmented macules appeared meanwhile on her face when her age of 9 and also have been spread diffusely on the cheeks and eyelids at visiting. Sh was otherwise normal on physically and had no familial history of such pigmentary disorder. But she had mental deficiency (I.Q. 60).
Cheek ; Child ; Extremities ; Eyelids ; Female ; Fingers ; Foot ; Forearm ; Hand ; Humans ; Intellectual Disability ; Leg ; Toes