PURPOSE: The purpose of our study was to evaluate the relevance of a patient's critical comorbidities to his survival rate, along with factors that influence the prognosis of patients who went through in-hospital cardiac arrest. We also investigated the association between the physical burden of the patients' comorbidities and the prognosis of inhospital arrest patients using the Deyo-Charlson score. METHODS: We retrospectively reviewed data for 1,094 patients with in-hospital cardiopulmonary arrest between January 2003 and June 2009 according to the Utstein-style guidelines. Severe comorbidities included congestive heart disease, chronic renal failure, severe liver disease, pulmonary disease, and hematologic or metastatic solid malignancy. Multivariate Cox regression analysis and logistic regression models were used to assess the hazard ratio and survival factors. RESULTS: The hazard ratio of patients with severe liver disease or hematologic or metastatic solid cancer were 1.42 (95% CI, 1.14-1.76, p=0.002) and 1.60 (95% CI, 1.36-1.88, p<0.001), respectively. Shorter CPR duration and subsequent intervention were significant prognostic factors in patients with severe comorbidities. The Deyo-Charlson score was one of the independent prognostic factors in the overall study population. CONCLUSION: The six month survival rate of patients with a history of severe liver disease or hematologic or solid metastatic cancer that underwent in-hospital cardiac arrest is low.
Cardiopulmonary Resuscitation ; Comorbidity ; Estrogens, Conjugated (USP) ; Heart Arrest ; Heart Diseases ; Humans ; Kidney Failure, Chronic ; Liver Diseases ; Logistic Models ; Lung Diseases ; Prognosis ; Retrospective Studies ; Survival Rate

PURPOSE: The purpose of this study is to histologically and histomorphometrically evaluate the effect of PLGA on bone regeneration compared with bone graft material. METHODS:The experimental study was conducted in 10 rabbits with 2 different healing periods of 2 and 4 weeks. Following surgical exposure of the calvarium, 4 circular bone defects with a diameter of 4.6mm were formed. Rabbits were divided into control group, test groups I, and II. 10 defects assigned to the test group I were grafted with Nu-oss and other 10 defects assigned to the test group II were grafted with PLGA. The rest of the defects were in the negative control group. At 2nd and 4th week after surgery, 10 rabbits were sacrificed through intracardiac perfusion and then specimens were obtained. Histological analysis was performed following staining with trichorme and transversal sectioning of the calvarial bone. RESULTS: A group which used PLGA showed tissue reactions characterized by severe inflammation, rather than distinctive new bone formation. CONCLUSIONS: The present experimental investigations have failed to prove any beneficial effects of PLGA. PLGA used in this study exhibited foreign body reactions and a less favorable pattern of new bone formation in comparison to control group. CONCLUSION: PLGA did not function as scaffold. Further investigations of many types of micro PLGA that could improve its potential in GBR procedures are needed.
Bone Regeneration ; Bone Substitutes ; Foreign Bodies ; Inflammation ; Lactic Acid ; Osteogenesis ; Perfusion ; Polyglactin 910 ; Polyglycolic Acid ; Rabbits ; Skull ; Transplants

PURPOSE: This study was designed to compare the bond regeneratiom effects of treatment using silk fibroin membrane ( Nanogide-S (R)) resorbable barrier with control group treated by polyactic acid / polylacticglycolic acid membrane(Biomesh (R) ) METHODS:44 severe bone loss on extraction socket from 44 patients were used in this study. In experimental group 22 sites of them were treated by silk fibrin membrane as and the other 22 sites were treated by polyactic acid/ polylacticglycolic acid membrane as a control group. Clinical parameters including recovered bone width, length and radiographic parameter of vertical length were evlauated at base line and 3 months after surgery. RESULTS: 1) Severe bone width, length was significantlly decreased in two group. 2) Bone width, length was significantlly decreased in two group. 3) Decreased bone width, length and radiographic examination differences between group. CONCLUSIONS: On the basis of these results, silk fibrin resorbable membrane has similar bone regeneration ability to polyactic acid / polylacticglycolic acid membrane in guided bone regeneration for severe bone loss defect on extraction socket.
Bone Regeneration ; Fibrin ; Fibroins ; Humans ; Lactic Acid ; Membranes ; Polyglycolic Acid ; Regeneration ; Silk