1.A Case of Xanthogranuloma on Scalp in Adult.
Young Il CHUN ; Shin Kyoo KIM ; Kyu Joong AHN ; Young Jin OH ; Yoo Shin LEE
Korean Journal of Dermatology 1985;23(3):408-410
Juvenile xanthogranuloma is characterized by one, or oftener many, yellow, re3dish yellow, or, brown 4-to-20 mm papules or nodules on the face, scalp, trunk, and mostly, extensor surfaces. It may involve internal organ besides the skin such as eye, gastrointestinal and genitourinary tracts. anthogranuloma in adult is usually solitary and dose not involve organs other than skin, and generally dose ncit resolve without treatment. Histopathologically, characteristic Touton giant cells usually appear numerously. We report a case of juvenile xanthogranulorna which occured on scalp of 49 year-old male showing typical clinical and histopathological findings.
Adult*
;
Giant Cells
;
Humans
;
Male
;
Middle Aged
;
Scalp*
;
Skin
;
Xanthogranuloma, Juvenile
2.Muscle-Specific Receptor Tyrosine Kinase Antibody Positive Myasthenia Gravis Current Status.
Journal of Clinical Neurology 2009;5(2):53-64
Muscle-specific tyrosine-kinase-antibody-positive myasthenia gravis (MuSK-MG) has emerged as a distinct entity since 2001. This disease has been reported worldwide, but with varying rates among patients with generalized acetylcholine-receptor-antibody-negative MG. MuSK-MG was detected in approximately 37% of generalized acetylcholine receptor antibody-negative MG. MuSK-MG patients were predominantly female with more prominent facial and bulbar involvement and more frequent crises. Disease onset tended to be earlier. Patients tended to have a relatively poor edrophonium response but showed prominent decrement in the repetitive nerve stimulation test in the facial muscles. Patients were more likely to display poor tolerance of, or a lack of improvement with, anticholinesterase agents. Somewhat better response was observed with steroids and plasma exchange. Most were managed successfully with aggressive immunomodulatory therapies, although a higher proportion of MuSK-MG patients had a refractory course when compared with other forms of generalized MG. I present here an up-to-date overview on MuSK-MG based on our experience at the University of Alabama at Birmingham and the existing literature.
Acetylcholine
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Alabama
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Cholinesterase Inhibitors
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Edrophonium
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Facial Muscles
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Female
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Humans
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Immunomodulation
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Myasthenia Gravis
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Plasma Exchange
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Protein-Tyrosine Kinases
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Steroids
;
Tyrosine
3.Relationship of Insulin like Growth Factor I with Pharmacologically Stimulated Growth Hormone Secretion in Growth Hormone Deficient Children.
Phil Soo OH ; Ki Joong KIM ; Young Iee YU ; Jeh Hoon SHIN
Journal of the Korean Pediatric Society 1995;38(10):1394-1403
No abstract available.
Child*
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Growth Hormone*
;
Humans
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Insulin*
;
Insulin-Like Growth Factor I*
4.Relationship between the Physiologic Night-Times surge and the Stimulated Peak Growth Hormome Levels in the Growth Hormone Deficiency Suspicious Children.
Phil Soo OH ; Jae Hoon SHIN ; Jae Kook CHA ; Ki Joong KIM
Journal of Korean Society of Endocrinology 1998;13(1):16-23
Nowadays, to evaluate growth hormone(GH) deficiency-suspicious short stature, we usually use more than two kinds of provocative tests using various pharmacologic agents such as clonodine, L-dopa, insulin, etc. However, the importance of physiologic natural secretion of GH was recently approved. In the past, diagnosis of GH neurosecretory dysfunction was made by studying the 24-hour spantaneous GH secretion profile. But, because it is very clinically difficult, and so we measured and evaluated the mean GH concentrations of blood samples, obtained every 30 minutes during the first 3 hours' nocturnal sleep, instead of that. At the department of Pediatrics, Hanyang University Hospital from November, 1992 to February, 1994, we selected 34 GH deficiency-suspected children on the base of their growth data and bone age, etc. After GH stimulation with clonidine(100-150 ug/m2) and L-dopa(200-250 mg/m2), we measured their peak GH values by the immunoradiometric assay(IRMA) kit. And, we measured the mean GH concentrations of blood samples, obtained every 30 minutes during the first 3 hours noctumal sleep(22:OOPM-1:OOAM). RESULTS: 1. We analyzed the relationship between the mean of 3-hours' physiologic night-time surge of GH(X) and the phamacologically stimulated peak GH level(Y), except for the two neurosecretory dysfunction suspicious children. And so, for the 32 children, the relationship was Y=1.806X+ 3.177, r= 0.794, p<0.01. However, for all the tested children(34), the relationship is Y=1.709X+ 4.06, r=0.737, p<0.01. 2. We analyzed the relationship between the peak of 3-hours' physiologic night-time surge of GH(X) and the phamacologicaUy stimulated peak GH level(Y), except for the two neurosecretory dysfunction suspieious children. And so, for the 32 children, the relationship was Y=0.683X+ 3.686, r=737, p<0.01. CONCLUSION: For all the tested children(34), the relationship between the mean 3hr physiologic GH night time surge and stimulated peak GH value is Y=1.709X+4.06, r=0.737, p<0.01. The percentage of GH neurosecretory dysfunction is 5.8%(2/34). And, except for the two childrren, the relationship is more good, Y=1.806X+3.177, r=0,794, p<0.01. On the above relationship, the 3-hour GH night time-surge test might to give us some helpful information for the diagnosis of neurosecretory dysfunction.
Child*
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Diagnosis
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Growth Hormone*
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Humans
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Insulin
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Levodopa
;
Pediatrics
6.Clinical Features of Group B Streptococcus Colonization in Vagina During Late Pregnancy at a Primary Maternity Hospital
Journal of the Korean Society of Maternal and Child Health 2022;26(1):27-34
Purpose:
The aim of this study was to assess the epidemiologic and clinical features of maternal Group B Streptococcus (GBS) colonization in vagina during their third trimester.
Methods:
This study included 644 pregnant women who had undergone GBS culture test in their third trimester in 2018. We collected data from the primary level of care maternity hospital through the retrospective chart review. We compared patients’ demographics, maternal obstetrical complications and neonatal adverse events between GBS positive (n=41) and GBS negative (n=603) groups. To find out clinical predictors of GBS positive result, univariable chi-square test and multivariable logistic regression analysis were applied.
Results:
The colonization rate of GBS in maternal vagina was 6.4% in their third trimester. GBS positive group showed significant association with the third trimester anemia (hemoglobin level <10.5 g/dL) (p=0.013) and oligohydramnios (p=0.024; odds ratio, 7.32; 95% confidence interval, 1.28–41.31). All specimens were susceptible to penicillin G and cephalosporin. The antibiotic resistance to both erythromycin and clindamycin was 31%.
Conclusion
The colonization rate of GBS in maternal vagina was 6.4% and third trimester maternal anemia was associated with the GBS carrying status.
7.Regulation of tumor necrosis factor-alpha gene expression by gluco-corticoid, dehydroepiandrosterone, and 1,25-dihydroxyvitamin D3.
Hyun Chul LEE ; Joon Haeng RHEE ; Boo Ahn SHIN ; Joong Yeol KIM ; In Chol KANG ; Jong Suk OH
Korean Journal of Immunology 1992;14(1):41-52
No abstract available.
Calcitriol*
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Dehydroepiandrosterone*
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Gene Expression*
;
Tumor Necrosis Factor-alpha*
8.Regulation of tumor necrosis factor-alpha gene expression by gluco-corticoid, dehydroepiandrosterone, and 1,25-dihydroxyvitamin D3.
Hyun Chul LEE ; Joon Haeng RHEE ; Boo Ahn SHIN ; Joong Yeol KIM ; In Chol KANG ; Jong Suk OH
Korean Journal of Immunology 1992;14(1):41-52
No abstract available.
Calcitriol*
;
Dehydroepiandrosterone*
;
Gene Expression*
;
Tumor Necrosis Factor-alpha*
9.Case Report: Intramasseteric Vascular Anomaly-Misdiagnosed to Parotid Sialolithiasis.
Joong Wha KOH ; Jeong Hoon OH ; Jee Churl SHIN ; Sun Yong KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1999;42(3):380-385
Intramuscular hemangiomas are benign vascular lesions of skeletal muscle and constitutes less than 1% of all hemangiomas. Of all intramuscular hemangiomas, 13-25% occur in the head and neck, presenting lesions of enlarging soft tissue mass associated with pain. Usually they do not exhibit cutaneous changes, such as bluish skin discoloration as seen in cutaneous and superficial subcutaneous lesions. Because of their infrequency, deep location and unfamiliar presentation, intramuscular hemangomas are seldom correctly diagnosed clinically. We encountered a case of intramasseteric hemangioma in a 14-year-old female. She presented intermittent painful swelling on the right preauricular area. Sialography showed a multiple calcified lesion of the soft tissue, while CT scan and MRI showed a tumor mass lying in the masseter muscle. Angiography showed blush lesion but no tumor feeding arteries. After 6 months of intra-lesional sclerosing therapy with alcohol, total regression of tumor was obtained. As we experienced in this case, percutaneous sclerotherapy with alcohol could be the first therapeutic alternative.
Adolescent
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Angiography
;
Arteries
;
Deception
;
Female
;
Head
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Hemangioma
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Humans
;
Magnetic Resonance Imaging
;
Masseter Muscle
;
Muscle, Skeletal
;
Neck
;
Salivary Gland Calculi*
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Sclerotherapy
;
Sialography
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Skin
;
Tomography, X-Ray Computed
10.Distribution of HLA-A, B, C Allele and Haplotype Frequencies in Koreans.
Sang Hyun HWANG ; Heung Bum OH ; Jin Hyuk YANG ; Oh Joong KWON ; Eun Soon SHIN
The Korean Journal of Laboratory Medicine 2004;24(6):396-404
BACKGROUND: The HLA system is known to be the most polymorphic gene cluster in the human genome. HLA allele and haplotype distribution varies widely among different ethnic groups. In this study, we examined the frequency of HLA class I alleles and haplotypes in 309 healthy Koreans. METHODS: We typed HLA-A, -B, and -C genes at the allelic level in 109 unrelated Korean individuals using a sequence-based typing. With the additional data of 200 healthy Koreans from dbMHC (http: //www.ncbi.nlm.nih.gov/mhc/), allele and haplotype frequencies were estimated by the maximum likelihood method. Serological typing results of 49 individuals were compared with the results highly resolved. RESULTS: A total of 22 HLA-A, 41 HLA-B, and 21 HLA-C alleles were found in this study. Alleles showing frequencies of more than 10% in each HLA locus were A*2402 (22.5%), A*0201 (15.7%), A*3303 (14.4%), A*1101 (11.0%), B*5101 (12.1%), Cw*0102 (18.8%), and Cw*1402 (10.2%). The most common A-B-C haplotypes at a frequency of more than 3% were A*3303-B*5801-Cw*0302 (5.2%), A*2402-B*5101-Cw*1402 (4.5%), A*1101-B*1501-Cw*0401 (4.3%), A*3303-B*4403-Cw*1403 (4.0%), A*3001-B*1302-Cw*0602 (3.7%), and A*0207-B*4601-Cw*0102 (3.2%). Misassignment of HLA-C antigen by serotyping was detected in 11 (22.4%) of 49 individuals. CONCLUSIONS: Our results will be useful as a basic data for studies on anthropology, disease association, and bone marrow transplantation. Misidentification of HLA-C by serotyping is so high that it would be desirable to perform a DNA typing especially in unrelated bone marrow transplantation.
Alleles*
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Anthropology
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Bone Marrow Transplantation
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DNA Fingerprinting
;
Ethnic Groups
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Genome, Human
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Haplotypes*
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Histocompatibility Testing
;
HLA-A Antigens*
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HLA-B Antigens
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HLA-C Antigens
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Humans
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Multigene Family
;
Serotyping