No abstract available.
Eosinophils* ; Humans ; Parotid Gland* ; Radiotherapy*

To examine AZT resistance of HIV-1 isolates from AZT treated or untreated Korean, several biological characteristics such as syncytium formation, HIV-1 reverse transcriptase activity and the p24 antigen production in MT-2 cells infected with 4 HRT_1 isolates were determined. As controls, we tested HIV-1 HTLV-IIIB and pre-drug isolate as AZT susceptible strains, in addition to HIV-1 RTMC/MT-2 and post-drug isolate as AZT resistant strains. When the inoculum size of HIV-1 was 300 TCID50well and 100 TCID50/well, the AZT susceptibility of AZT untreated HIV-1 isolates 8806 and 9571 were similar to that of HIV-1 HTLV-IIIB and AZT-susceptible HIV-1 strains. When we evaluated AZT resistance of isolates HRs-1 8812 and 9113 treated with AZT for 36 months by observation of syncytium formation, HIV-1 8812 showed resistance simillar to that of HIV-1 RTMC/MT-2 strain forming syncytium up to AZT 1microgram/ml, and HIV-1 9113 showed resistance identical with that of AZT-resistant HIV-1 strain which formed syncytium up to AZT 10 microgram/ml. Especially, when we evaluated AZT resistance by HIV-1 reverse transcriptase activty and the p24 antigen production, HIV-1 isolates 8812 and 9113 showed much higher resistance (>10 - 200 fold) compared with HN-1 RTMC/MT-2 and AZT-resistant HIV-1 strain.
Giant Cells ; HIV-1* ; Korea* ; Population Characteristics ; RNA-Directed DNA Polymerase ; Zidovudine*

PURPOSE: The purpose of this study was to review sexual abuse prevention education program for Korean elementary school students.METHODS: Whittemore and Knafl's integrative review methods were used and Gough's weight of evidence was employed as a quality appraisal tool. Articles published in Korean or English were identified through electronic search engines and scholarly web sites using three keywords: “elementary school student”, “sexual abuse”, and “prevention education”. Peer-reviewed articles published between 2000 and 2018 were included in this review.RESULTS: Twelve articles met the inclusion criteria and were appraised as being high-quality. Among the 12 selected studies, seven were descriptive, while five were intervention studies. Sexual abuse prevention education programs were effective in improving perceptions, knowledge, attitudes, and preventive behaviors among elementary school students. However, deficiencies were found in the variety of educational methods, utilization of experts, and standardization of the content of sexual abuse prevention education.CONCLUSION: We need to provide various educational methods that are appropriate for specific developmental stages, and the sexual abuse prevention content should draw upon the current sexual education program administered to this population. Furthermore, parents and trained teachers or school health teachers should be included to provide effective education programs for elementary students.
Child ; Child Abuse, Sexual ; Education ; Humans ; Korea ; Parents ; School Health Services ; Search Engine ; Sex Offenses

PURPOSE: The objective of this study was to provide an understanding of the difficulties for facing parents of children with terminal cancer. METHOD: The design of this study was an inductive and descriptive study. Thirty-one parents of children with terminal cancer participated in-depth were interviewed s. C in depth and content analysis was used for analyzing the data. RESULTS: The main categories in the findings were 'difficulties in coping', 'physical and psychological suffering of children', 'suffering of family', 'bereavement with children', 'economic problems', 'incurable situation', 'preparation of death', 'social isolation', 'coping after a child dies', 'spiritual problems', receiving active treatment', 'informing children of their condition', 'a sense of meaninglessness', 'emotional iunstability', and 'giving up hope'. CONCLUSION: The main point identified from this result in this study was that parents who have a child with terminal cancer don't never give up the hope of recovery for their child even when the child is in by the terminal stage of their children, even though and they are unwillingly to prepare for their child's death. This is a unique characteristic in the attitude of the families' attitude in child hospice care and differs from that found in adult hospice care. This result can be used as an important guide for nurses to in assessing the parents' needs in the terminal care setting.
Adult ; Child* ; Hope ; Hospice Care ; Humans ; Parents* ; Terminal Care ; Child Health

Glycogen storage diseases(GSD) are inherited disorders affecting glycogen metabolism and type I GSD is due to the absence or deficiency of glucose-6-phosphatase(G6Pase) enzyme in the liver, kidney, and intestinal mucosa. The defect leads to inadequate hepatic conversion of G6P to glucose and thus make affected individuals susceptible to fasting hypoglycemia, and the accumulation of glycogen occurs in the liver and other organs. Type Ia is the most common form of GSD and clinically growth retardation may manifest of GSD itself rather than growth hormone deficiency(GHD), but we experienced a case of type I GSD with GHD in a 14-year-o1d male. The height was 125 cm, compatible with 50 th percentile of height of 8 years of age. He has doll-like face with fat cheek, relatively thin extremities, and metabolic acidosis, hyperuricemia, hypoglycemia, hyperlipidemia. GH stimulation test with clonidine and L-dopa revealed that the patient had decreased GH secretion. After laboratory work up including liver biopsy, he was diagnosed as type I GSD. Hypoglycemia was managed with frequent feeding with high starch diet(uncooked cornstarch). Metabolic acidosis and hyperuricemia were treated with sodium bicarbonate, allopurinol and probenecid. The patient is being followed at out-patient clinic with clinical improvement after of diet therapy and GH administration.
Acidosis ; Allopurinol ; Biopsy ; Cheek ; Clonidine ; Diet Therapy ; Extremities ; Glucose ; Glycogen Storage Disease* ; Glycogen* ; Growth Hormone* ; Humans ; Hyperlipidemias ; Hyperuricemia ; Hypoglycemia ; Intestinal Mucosa ; Kidney ; Levodopa ; Liver ; Male ; Metabolism ; Outpatients ; Probenecid ; Sodium Bicarbonate ; Starch

PURPOSE: The purpose of this study was to set up a hypothetical model to explain causal relationships among influential variables in the mother-child relationship for Korean infants and toddlers and their mothers. The research was based on Barnard's (1978) mother-child relations model, and goodness-of-fit was examined. METHODS: The participants were 207 mothers with infants or toddlers. Data were analyzed using SPSS and AMOS programs. RESULTS: Regarding the influence of the variables on the mother-child relationship between infants and toddlers and their mothers, social support had a 75% explanation of mother-child relationships, and attachment had a 58% explanation of social support. Attachment had both direct and indirect effects on the mother-child relationships, and social support had direct and total effects on the mother-child relationships. Among child-related variables, child temperament had a moderating effect on the mother-child relationships. CONCLUSION: The findings indicate that the model has utility in developing effective nursing intervention methods to boost mother-child relationships between infants and toddlers and their mothers.
Child ; Humans ; Infant* ; Mother-Child Relations* ; Mothers* ; Nursing ; Temperament

Behcet's disease is a chronic, multi systemic disorder which is more frequently seen in the Mediterranean basin, Middle East, and Far East. One thousand four hundred fifty four patients, who had visited the Behcet's Disease Specialty Clinic of Yonsei Universtiy, College of Medicine from November, 1983 to December, 1990, were grouped into 4 groups by Shimizu's classification, and their clinical and epidemiological characteristics were evaluated. 1. The disease occurred more often in women than men, and the mean age of onset was 29.0 years old. 2. About 85% of the patients were from Seoul, Kyunggi, and lnchon. 3. The number of new patients has increased yearly. 4. By the Shimizu classification, incomplete type was most common. 5. The most frequent major symptom was oral ulcer (97.5%), and the most frequent minor symptom was arthritis (29.5%). The most frequent initial symptom was oral ulcer (78.1%). 6. The mean interval between the initial symptom and ocular symtom was 44 months. 7. Ocular lesions appeared in 239 patients, and occurred more often in men than women. Their mean age was 28.2 years old, and the most common ocular symptom was iritis (64.0%). 8. About 30% of the patients had corrected visual acuity of 0.01 or worse at their first visit. Visual acuity was worsened in 50.9% of the eyes followed for over 24 months. 9. Twenty nine Behcet's disease patients with refractory ocular involvement were treated with Cyclosporin A (CYA), and visual acuity was improved in 52.7% of the patients treated over 6 months with CYA.
Age of Onset ; Arthritis ; Classification ; Cyclosporine ; Far East ; Female ; Gyeonggi-do ; Humans ; Iritis ; Male ; Middle East ; Oral Ulcer ; Seoul ; Visual Acuity

No abstract available.
Humans*

PURPOSE: This study was intended to investigate the types and seriousness of the couvade syndrome, pregnancy-related physical and psychological symptoms among expectant fathers whose spouses were pregnant. METHOD: The subject was consists of 100 expectant fathers at one hospital in Seoul, Korea. The pregnant women had not been diagnosed any medical complication. Data were analyzed by SPSS/PC program. RESULT: 1) The total mean score was 1.85: the mean score of perceived physical symptoms (1.87) revealed higher than the mean score of psychological symptoms (1.81). 2) With the respect to the general characteristics of subjects, there were statistically significant correlations between subject's level of education and couvade symptoms (r=-.209, p=.037), gestational age and couvade symptoms (r=-.227, p=.023), family total income and couvade symptoms (r=-.198, p=.048), perceived self health status and couvade symptoms (r=-.254, p=.011). 3) With the respect to the general characteristics of subjects, there were statistically significant differences in pregnant woman's age (t=1.363, p=.044),occupation of subject (F=3.594, p= .009), educational level of subject (t=3.506, p=.002), family total income (F=16.822, p= .000), perceived self health status (F=3.151, p=.047). CONCLUSION: Couvade syndrome is an issue for nurses who perform an important role in the care of pregnant women and their spouses.
Education ; Fathers ; Female ; Gestational Age ; Humans ; Korea ; Pregnant Women ; Seoul ; Spouses*

No abstract available.