Objective For better recognition of the hereditary nonpolyposis colorectal cancer (HNPCC) with reference to its clinical characteristics, diagnosis and treatment [WT5”HZ]Methods [WT5”BZ] A survey of 7 families of HNPCC patients was made [WT5”HZ] Results [WT5”BZ]Among the 7 families, 21 persons had colorectal cancer with age ranging from 26 to 79 years (average 46 years) The total of the colorectal cancer foci in 21 cases were 31,among which 16 were located proximal to,10 distal to the splenic flexure and 5 without definite record 61 5%(16/26) of the colorectal cancer foci were located proximal to the splenic flexure Six patients had multifocal colorectal cancer, which accounted for 28 6%(6/21) of all cases [WT5”HZ] Conclusions [WT5”BZ] HNPCC patients and their family members should be followed up regularly for early diagnosis and treatment of the disease and for better prognosis

Objective To investigate if the prognosis of young patients with colorectal cancer (CRC) is influenced by their familial predisposition. Methods The patients with CRC under 40 years old, underwent operation, had pathological diagnosis , family survey, followed up etc were selected into this research. According to familial predisposition they were divided into two groups: group A (with familial predisposition) and group B (without familial predisposition). Results Among the 44 patients twelve were in group A, thirty-two in group B. The 5-year survival rate in group A and B was 83.30%(10/12) and 59.38%(19/32) respectively,the difference was significant between the two groups(? 2=5.64,P

Objective To explore the relationship between the expression of human telomerase RNA component (TERC) gene , human papilloma virus (HPV) infection and mutation of chromosome 3 number with cervical lesions .Methods 81 women received the treatment in the Gynecology Department of the Second Affiliated Hospital of Kunming Medical University from June 2008 to February 2009 ,including the healthy group(normal pathological examination ,20 cases) ,CIN1 group(28 cases) ,CIN2 group(12 ca‐ses) ,CIN3 group(9 cases) and cervical cancer group(12 cases) .The TERC gene expression in uterine epithelial exfoliated cells was detected by using the fluorescence in situ hybridization (FISH) method ,meanwhile the HPV infection was detected by using the real time fluorescence quantitative polymerase chain reaction (FQPCR) technology .The correlation between cervical cancer with TERC gene and HPV was analyzed .At the same time the number of chromosome 3 mutations in 81 cases was recorded .Results In the cervical lesion detection ,the detection positive rate had no statistical difference between the TERC gene detection and HPV detec ‐tion (P> 0 .05) ,their positive rates in the CIN 1 ,CIN2 ,CIN3 and cervical cancer groups were significantly higher than that in the healthy group (P< 0 .05) ,the difference between the CIN1 group and the CIN2 group had no statistical significance (P > 0 .05) , while between the CIN3 group and the cervical cancer group had statistical significance (P< 0 .05) ,the higher the malignant degree , the higher the positive rate .The abnormal mutation rate of chromosome 3 number was 0% in the healthy group and the CIN1 group ,16 .7% in the CIN2 group ,66 .7% in the CIN3 group and 100 .0% in the cervical cancer group ,the positive rate in the CIN3 group and the cervical cancer group was significantly higher than that in the healthy group ,CIN1 group and CIN2 group ,the differ‐ences were statistically significant (P< 0 .05) .Conclusion The TERC abnormal gene expression ,high risk HPV infection and mutation of chromosome 3 number could play an important synergistic effect during the process of occurrence and progression of cervical cancer .

Objective:To investigate the expressions of CC chemokine receptor 3 (CCR3) and CC chemokine 5 (CCL5) in serum of patients with non-small cell lung cancer (NSCLC) and their predictive value for recurrence and metastasis after surgery.Methods:The clinical data of 90 NSCLC patients (NSCLC group) who underwent surgery in Rugao People's Hospital from January 2017 to December 2020 were retrospectively analyzed. At the same time, 95 healthy people who underwent physical examination during the same period were selected as the healthy control group. The levels of serum CCR3 and CCL5 in the two groups were detected by enzyme-linked immunosorbent assay. After a 2-year postoperative follow-up, the NSCLC patients were recorded for recurrence and metastasis after surgery. Multivariate logistic regression analysis was used to identify the independent factors affecting patients' recurrence and metastasis after surgery. Receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of CCR3 and CCL5 levels for patients' recurrence and metastasis after surgery.Results:The levels of CCR3 and CCL5 in NSCLC group were higher than those in the healthy control group [(290±36) pg/ml vs. (183±23) pg/ml; (15.7±3.1) pg/ml vs. (6.2±1.2) pg/ml], and the differences were statistically significant ( t values were 24.02 and 27.24, both P < 0.001). The incidence of recurrence and metastasis after surgery in NSCLC group was 34.44% (31/90). The levels of CCR3 and CCL5 in patients with recurrence and metastasis were higher than those in patients without recurrence and metastasis [(315±39) pg/ml vs. (276±35) pg/ml; (17.5±3.4) pg/ml vs. (14.7±2.9) pg/ml], and the differences were statistically significant ( t values were 4.87 and 4.04, both P < 0.001). The result of univariate analysis showed that the proportions of patients with stage Ⅲ A, poorly differentiation and lymph node metastasis in patients with recurrence and metastasis were higher than those in patients without recurrence and metastasis (all P < 0.05). Multivariate logistic regression analysis showed that TNM stage ( OR = 2.587, 95% CI 1.509-4.434), CCR3 level ( OR = 2.215, 95% CI 1.354-3.623) and CCL5 level ( OR = 2.343, 95% CI 1.193-4.598) were independent factors affecting patients' recurrence and metastasis after surgery (all P < 0.05). ROC curve analysis showed that the areas under the curve (AUC) of CCR3, CCL5 and combination of the two in predicting NSCLC patients' recurrence and metastasis after surgery were 0.710, 0.684 and 0.854. Conclusions:The abnormal high expressions of CCR3 and CCL5 in the serum of NSCLC patients are independent risk factors for recurrence and metastasis after surgery. The combined detection of CCR3 and CCL5 can effectively predict the recurrence and metastasis of patients after surgery.

Objective Explore the feasibility and accuracy of using deep learning techniques for gender inference in panoramic dental radiography images of Chinese Han population.Methods A total of 10,600 OPG images from Han individuals aged 18 to 70(5,300 males and 5,300 females)were collected and randomly divided into training set,validation set,and test set in an 8:1:1 ratio.MobileNetV2,Swin Transformer Small,and Swin Transformer Tiny models were trained,and the classification performance of the models was evaluated and visually displayed using accuracy,F1 score,and Grad-CAM algorithm.Results The accuracy of MobileNetV2,Swin Transformer Small,and Swin Transformer Tiny models was 97.57%,95.13%,and 96.28%respectively,with MobileNetV2 model showing the best overall performance.The Grad-CAM algorithm revealed that male OPG images mainly focused on the left and right mandibular branches and alveolar bone,while female OPG images mainly focused on the maxillary sinus,left mandibular branch,and posterior alveolar bone.Conclusion This study demonstrates that the gender inference model based on deep learning techniques for OPG images of Chinese Han population has high accuracy and generalization ability,providing a new approach for forensic gender determination in forensic medicine.