Objective To investigate the clinical application a small dose of ropivacaine in elderly patients undergoing transurethral resection of prostate (TURP).Methods 84 elderly patients with benign prostatic hyperplasia treated by TURP were randomly divided into the control group and the observation group with 42 cases.The control group was given routine dose of ropivacaine for epidural anesthesia,while the observation group was treated with a small dose of ropivacaine for combined spinal-epidural anesthesia.The anesthetic effect,blood flow dynamic changes and adverse reactions were compared between two groups.Results The highest sensory block level of the two groups was no significant difference (t =1.08,P ＞ 0.05).The highest block time of the observation group was shorter than the control group,there were statistical different significantly between the two groups (t =4.21,P ＜ 0.05).The anesthetic effect excellent rate was 100％ in the observation group and the anesthetic effect excellent rate was 88％ in the control group.It was higher than control group,there were statistical different significantly between the two groups (x2 =5.31,P ＜ 0.05).All indicators were statistical different significantly between the two groups except blood pressure differences.The hypotension and the overall incidence of adverse reactions in the control group were higher than the observation group,there were statistical different significantly between the two groups (x2 =4.09,12.81,all P ＜0.05).Conclusion It has a good anesthetic effect,stable hemodynamics,adverse reactions are mild,motor block is light wait for a characteristic by a small dose ropivacaine combined spinal-epidural anesthesia for elderly patients with TURP.It is worthy to recommend its clinical use.

Candida albicans is one of the most common species of Candida, which is an important cause of invasive candidiasis in clinic. Due to the frequently use of classical antifungal agents, there are amounts of drug resistant C. albicans being isolated, causing the significantly decreasing of the efficacy of some antifungal agents in clinical treatment. Besides, the use of some compounds in clinic has been limited because of their toxicities. In such a context, drug combination therapy shows great potential on antifungal because of the synergy of different drugs or therapeutic methods that could bring, which could improve the weaknesses of single drug.