1.Total subadventitial cystectomy for the treatment of 30 patients with hepatic hydatid cyst
Xinyu PENG ; Shijie ZHANG ; Jianhua NIU
Chinese Journal of General Surgery 2001;0(09):-
Objective This study was to evaluate a new radical resection of hepatic hydatidosis. MethodSince 1999, total subadventitial cystectomy through the intraadventitial space of the hepatic hydatid cyst was performed on thirty patients with 45 liver hydatid cysts. Results The procedure was successful in all cases with no intraoperative rupture of the cysts. The average blood loss per cyst was 20?ml. There was no operative mortality, nor postoperative complications. Twenty one cases were followed up for an average period of 11 months with no recurrence. Conclusions The results indicate that the new procedure is a safe and radical alternative for the treatment of hepatic hydatidosis.
2.Clinical significance of urodynamic detection in patients with diabetic cystopathy complicated with benign prostatic hyperplasia
Jianmin ZHOU ; Shijie NIU ; Song TU ; Faying YANG ; Xiaoying SONG ; Yongwei SHAN ; Changjun YANG
Chinese Journal of Postgraduates of Medicine 2014;37(23):6-8
Objective To obtain reasonable treatment by urodynamic detection and analysis in patients with diabetic cystopathy (DCP) complicated with benign prostatic hyperplasia (BPH).Methods Sixty patients with DCP complicated with BPH were selected,among the total 32 patients (duration of diabetes > 12 years,blood glucose control was not ideal) were recognized as experimental group,and 28 patients (duration of diabetes ≤ 8 years,blood glucose control was stable) were recognized as control group.Using the Laborie UDS-120XLT urodynamic detection instrument,the urodynamic was detected and the international prostate symptom score (IPSS) was evaluate,and the results were compared between the 2 groups.Results There was no statistical difference in residual urine volume between experimental group and control group [(146 ±71) ml vs.(160 ±64) ml,P >0.05].The maximum urinary flow-rate in experimental group was significantly lower than that in control group [(5.4 ± 2.0) ml/s vs.(8.0 ± 3.2) ml/s],the symptom total score of IPSS was significantly higher than that in control group [(25.8 ± 4.1) scores vs.(22.6 ±5.0) scores],there were statistical differences (P <0.01).The maximum bladder capacity,compliance,incipient micturition desire volume in experimental group were significantly lower than those in control group,there were statistical differences (P < 0.01).Conclusions The influence of DCP on the function of the bladder in BPH patients is significant.Urodynamic detection can provide objective basis for the selection of therapeutic methods,suitable to be operated and forecast the postoperative effect.It has an important reference value in DCP complicated with BPH patients.
3.Analysis of the risk factors of chronic cough in children
Liyan LUO ; Haoping RAO ; Shijie JIN ; Niu DING ; Ting YANG ; Shujuan LUO
Journal of Chinese Physician 2013;(5):617-620
Objective To explore the risk factors of chronic cough in children.Methods A hospital-based case-control study was conducted.A total of 60 children with chronic cough and 120 non-chronic cough children were interviewed with standard questionnaires.Non-conditional multivariable logistic model was performed to analyze the risk factors.Results Among 192 children that were performed questionnaire survey,180 cases were obtained the complete data with a questionnaire response rate of 93.75%.No significant difference in age,gender,and permanent residence was found between chronic cough and control groups,respectively (P >0.05).As shown in multivariable logistic model,parents with sensitive history (OR =1.924),mother or father smoking (mother:OR =1.989 ; father:OR =2.156),poor ventilation (OR =27.906),and interior decoration less than 3 months stay (OR =4.652) increased the risk of chronic cough in children.Conclusions Many factors,even the domestic environmental factors,are associated with chronic cough in children.It's time to strengthen the intervention of risk factors for reducing the occurrence of chronic cough in children.
4.Expression and clinical significance of PI3K and MMP-7 proteins in esophageal squamous cell carcinoma.
Lei WANG ; Xinqiang NIU ; Baoen SHAN ; Ming HE ; Xianli MENG ; Bing ZHANG ; Shijie WANG
Clinical Medicine of China 2009;25(10):1083-1085
Objective To study the expression of PI3K and MMP-7 in esophageal carcinoma and the rela-tionship between the expression of PI3K and MMP-7 and carcinogenesis and progression of esophageal carcinoma. Methods PI3K and MMP-7 expression were detected in 24 normal esophageal mucosa,94 primary tumor tissues with SP immunohistochemistal method. Results There were significant differences of PI3K and MMP-7 expressions between esophageal carcinoma and normal mucesa epithelium ( all P < 0.01 ) [71.28% (67/94) vs 4.17% ( 1/24 ) and 52.13% (49/94) vs 0% (0/24)]. There were significant correlations between PI3K expression and the degrees of differentiation,invasive depth,clinical staging and the metastasis of lymph node (all P <0.01 ). The positive ex-pression rate of MMP-7 had the relationship with metastasis of lymph node (P < 0.05 ), the degrees of differentiation ( P < 0.05 ) invasive depth ( P < 0.01 ), and clinical staging( P < 0.05 ) . There was a positive relationship between PI3K and MMP-7 expression in this study (r = 0. 232 ,P = 0.025). Conlusions PBK and MMP-7 play an impor-tant roles in carcinogenesis and progression of esophageal carcinoma and can be used as valuable biomarkers to eval-uate biological characteristics in esophageal squamous cell carcinoma.
5.Identification of Genetic Locus for Disseminated Superficial Actinic Porokeratosis
Zhenghua ZHANG ; Zhenmin NIU ; Jingjun ZHAO ; Xiaoyan XIONG ; Rong ZHAO ; Haiming ZHU ; Yuebin LI ; Shijie XU ; Weida LIU ; Wei HUANG
Chinese Journal of Dermatology 1994;0(06):-
Objective To identify the genetic locus for disseminated superficial actinic porokeratosis(DSAP).Methods Genome DNA was extracted from the whole blood of the family members of a pedigree of DSAP.Genotyping on chromosome12q that had been identified was performed by using7microsatellite mark-ers to scan the family members of DSAP and analysed with LINKAGE(5.1Version).Results A maximum2-point lod score of5.15with marker D12S79at a recombination fraction(?)=0.00was found.Conclusion Our study supports that DSAP gene localizes at the long arm of chromosome12,which was first reported in the literature.
6. Clinical analysis of 17 cases with surgical treatment of adrenal cysts
Yongwei SHAN ; Shijie NIU ; Song TU ; Faying YANG ; Yunpeng LI ; Shenghao NIU
Chinese Journal of Postgraduates of Medicine 2019;42(10):893-896
Objective:
To investigate the clinical characteristics and the effectiveness of surgical treatment of adrenal cysts.
Methods:
The clinical data of adrenal cysts in Affiliated Zhangye people′s Hospital, Hexi College from May 2005 to July 2018 were retrospectively analyzed, including clinical manifestations, diagnosis, surgical methods, postoperative pathological results and follow-up process. Seventeen patients with adrenal cysts were identified including 10 males and 7 females. The median age was 45.6 ranging from 30 to 75. There were 12 left lesions and 5 right lesions. Only 4 patients (23.5%) had clinical symptoms, including low back pain, abdominal pain and dizziness caused by hypertension. Ultrasound, CT and MRI were the main imaging methods for preoperative diagnosis.
Results:
All patients underwent surgical treatment. Laparoscopic surgery was adapted in 14 cases. The average operation time was (70.2 ± 18.5) min and the average bleeding was (47.0 ± 12.1) ml. For open surgery in 3 cases, the average operation time was (103.5 ± 25.0) min and the average bleeding was (85.6 ± 20.5) ml. Postoperative pathological results showed endothelial cysts in 11 cases, epithelial cysts in 3 cases and pseudocysts in 3 cases. No recurrence of cysts or hypoadrenalism occurred in 3-75 months′ follow-up.
Conclusions
Adrenal cysts are relatively rare and generally benign lesions. Imaging examination, especially abdominal enhanced CT is essential for diagnosis. Laparoscopic surgery is a safe and effective method for the treatment of adrenal cysts.
7.Effects of seeds irradiation with 60Cogamma-ray on shoot growth and physiological status of Carthamus tinctorius.
Shijie NIU ; Wenrong YAN ; Xia WANG ; Xianen LI
China Journal of Chinese Materia Medica 2009;34(23):3004-3007
OBJECTIVETo provide the radiation-induced technical reference and theoretical basis for safflower and other medicinal plants.
METHODSeeds of Carthamus tinctorius were irradiated with 60Cogamma-ray, and germination rate of seeds, germination, seedling rate and seedling height, root length, fresh weight, root activity and peroxide catalase (CAT), peroxidase (POD), superoxide dismutase (SOD) activity were determined.
RESULT AND CONCLUSIONThe LD50 of radiation dose is about 300 Gy, effects of seeds irradiation with 6Co-gamma-ray on shoot growth and physiological status of C. tinctorius are obtained.
Carthamus tinctorius ; enzymology ; growth & development ; radiation effects ; Catalase ; metabolism ; Gamma Rays ; Germination ; radiation effects ; Peroxidase ; metabolism ; Plant Shoots ; enzymology ; growth & development ; radiation effects ; Seeds ; enzymology ; growth & development ; radiation effects
8.Rib's strapping-traction technology combined with memory-alloy ribs embracing fixator for multiple rib fractures under video-assisted thoracoscope
Dingfeng QIAN ; Xingbing ZHANG ; Jun SHANG ; Tong HUANG ; Shijie NIU ; Juncheng HE ; Kebai AI
Chinese Journal of Trauma 2018;34(5):432-437
Objective To investigate the clinical efficacy of rib's strapping-traction technology using absorbable implants combined with memory-alloy ribs embracing fixator in treating multiple rib fractures under video-assisted thoracoscope.Methods A retrospective case control study was performed to analyze 178 patients with multiple rib fractures treated from January 2015 to June 2017.According to the operation method,all patients were divided into observation group (91 patients) and control group (87 patients).The observation group including 59 males and 32 females aged (39.7 ± 7.8)years adopted internal fixation by rib's strapping-traction technology using absorbable implants combined with memory alloy ribs embracing fixator under video-assisted thoracoscopic surgery.The control group including 56 males and 31 females aged (40.2 ± 6.9) years adopted internal fixation by conventional rib's clamping-traction technology using towel forcep combined with memory-alloy ribs embracing fixator under video-assisted thoracoscopic surgery.The incision length,single rib internal fixation time,number of internal fixation rib fractures,visual analogue scale (VAS) score on postoperative 1 d,postoperative chest drainage,postoperative hospital stay,and postoperative fracture healing were compared between the two groups.Results All patients were followed up for 3-30 months (mean,16.7 months).All operations were successful,with no case of thoracotomy.The observation group had shorter incision length [(4.3 ± 1.2) cm vs.(6.2 ± 1.7) cm] and single rib internal fixation time [(10.3±2.9)min vs.(14.1 ±2.3)min] than the control group (P<0.05).There were no significant differences (P > 0.05) between the two groups in number of internal fixation rib fractures [(5.7±.3.6) vs.(5.9±3.3)],postoperative chest drainage [(668.3 ±131.4)ml vs.(703.7±116.2)ml],postoperative hospital stay [(6.4 ± 1.8) d vs.(6.8 ± 1.7) d],the VAS score on postoperative 1 d [0-3 point,62% vs.61%;4-6 point,38% vs.39%],postoperative osteophyte formation rate [postoperative 1 month,97% vs.95%;postoperative 3 months,100% vs.100%].Stable chest walls and thoracic deformity recovery were seen in all patients,with no significant complications occurred.Conclusion Rib's strapping-traction technology using absorbable implants combined with memory-alloy ribs embracing fixator under video-assisted thoracoscope is convenient and has exact efficacy for multiple rib fractures,with advantage of shorter incision length and operation time over conventional thoracoscopic surgery,and thus is worthy of clinical application.
9. Study on the effect of serum vitamin A and E on children with mycoplasma pneumoniae pneumonia based on propensity score matching
Chang XU ; Liyan LUO ; Niu DING ; Shijie JIN ; Shujuan LUO ; Ting YANG ; Bichen WU ; Huaping RAO
Journal of Chinese Physician 2020;22(1):43-45,49
Objective:
To explore the association between Vitamin A, E and mycoplasma pneumoniae pneumonia in children.
Methods:
153 children with mycoplasma pneumoniae pneumonia and 653 health children were selected as cases and controls, respectively. Propensity score matching (PSM) analysis were conducted to reducing confounding bias between groups. Blood samples were collected to test serum levels of vitamin A and E using high performance liquid chromatography (HPLC). Logistic regression was implemented to determine odds ratios (
10.Expression and prognostic value of PD-1 and Tregs in metastatic renal cell carcinoma
Jiaxi YAO ; Yujie QIN ; Yongwei SHAN ; Xiaoyi WEI ; Shijie NIU ; Xiaoyi HU ; Jianming GUO
Chinese Journal of Clinical Oncology 2018;45(19):980-984
Objectives: To evaluate the tumor-infiltrating PD-1 positive lymphocytes and regulatory T cells (Treg) as prognosis predic-tors of metastatic renal cell carcinoma (mRCC), and investigate the expression of PD-1 and Treg cells in mRCC and elucidate their corre-lation with clinicopathological parameters and prognosis. Methods: A total of 269 mRCC patients from June 2007 to June 2017 in Zhongshan Hospital, Fudan University, were included in the study. The expression of PD-1 and Tregs in mRCC samples were detected by immunohistochemistry. The relationship between the expression of PD-1 and Tregs was analyzed. Results: PD-1 positive expression in mRCC was 31.60% (85/269) and it was positively correlated with the tumor Fuhrman grade and negatively correlated with progno-sis. Tumor infiltration of Tregs in mRCC was 36.80% (99/269), and it was also positively correlated with the tumor Fuhrman grade and negatively correlated with prognosis. Univariate analysis showed that PD-1 positive lymphocytes and high Treg infiltration numbers were negatively correlated with overall survival (OS) and progression free survival (PFS) rates. Thus, PD-1 positive lymphocytes and high Treg infiltration numbers are independent prognostic indicators of OS and PFS and when combined, they can render a better pre-diction for prognosis. Conclusions: Intra-tumoral infiltration of PD-1 positive lymphocytes and Tregs can be used as significant prognos-tic indicators of mRCC, and the combined predictive effect is better than the individual predictive effect. Therefore, evaluating the number of PD-1 positive lymphocytes or infiltrating Tregs in mRCC is helpful in clinically estimating mRCC prognosis in patients.