Objective:To explore the similarities and differences between Opening Xuanfu therapy and Qingreliangxue therapy in the treatment of psoriasis based on the Network Pharmacology.Methods:The active ingredients and protein targets of the representative Traditional Chinese Medicine contained in drugs Qingreliangxue therapy and Opening Xuanfu therapy were screened out by Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), Encyclopedia of Traditional Chinese Medicine (ETCM) and Traditional Chinese Medicine Integrated Database (TCMID). The Targets of psoriasis were collected by GeneCards and OMIM databases. The intersections of component targets and disease targets were obtained by Venny 2.1.0, and then the protein-protein interaction (PPI) was constructed by String Platform and Cytoscape 3.9.0 to screen out the key targets in the two therapies that could treat psoriasis. GO functional enrichment analysis and KEGG pathway enrichment analysis were performed via the Metascape platform. The potential advantages of opening Xuanfu therapy in the treatment of psoriasis comorbidities are found out by using Venny and Cytoscape to compare the differences and visually analyze the above results.Results:8 ingredients are with the same effect and 73 ingredients are different in these two therapies. There are 43 identical and 15 different potential targets in these two therapies..10 representative key targets in each of the two therapies were obtained by PPI network analysis, including 7 identical key targets, namely HIF1A, MYC, CCND1, FOS, IL6, PPARG, NFKBIA, and 6 different targets. Go enrichment results show that there are 10 same biological processes in the first 20 articles of the two the therapies, including the response to external stimuli, the regulation of cell adhesion, the response to steroid hormone, the response to injury, the negative regulation of cell differentiation, the response to growth factors and metabolism of reactive oxygen species. KEGG enrichment results of the first 20 pathways in the two therapies show that there are 8 same pathways, including cancer-related pathways, fluid shear stress and atherosclerosis, MAPK signaling pathway, p53 signaling pathway, transcriptional imbalance in cancer and cholinergic synapse.Conclusion:Qingreliangxue therapy in the treatment of psoriasis mainly plays the role of antioxidant, anti-inflammatory, anti-proliferative and immune-regulating effects. The Opening Xuanfu therapy in the treatment of psoriasis mainly plays the role of regulating lipid metabolism, anti-inflammatory, regulating cell apoptosis, anti-oxidation, anti-proliferation, regulating angiogenesis and abnormal morphology.