Diagnostic Errors ; Glottis ; pathology ; Humans ; Larynx ; pathology ; Lymphoma ; diagnosis

Objective:To investigate the clinical efficacy of microscopic myringoplasty versus endoscopic myringoplasty in the treatment of tympanic membrane perforation caused by chronic suppurative otitis media. Methods:The clinical data of 91 patients with tympanic membrane perforation caused by chronic suppurative otitis media who received treatment in Jiaxing Second Hospital, China between February 2017 and March 2019 were retrospectively analyzed. These patients were divided into a control group ( n = 45) and an observation group ( n = 46) according to different surgery methods. The control group was given microscopic tympanoplasty, while the observation group was given endoscopic tympanoplasty under the otoendoscope. Results:Blood loss in the observation group was significantly lower than that in the control group [(7.2 ± 2.0) mL vs. (13.7 ± 3.1) mL, t = 11.912, P < 0.001]. Operation time in the observation group was significantly shorter than that in the control group [(59.4 ± 5.4) min vs. (91.5 ± 11.2) min, t = 17.474, P < 0.001]. Postoperative pain score in the observation group was significantly lower than that in the control group [(2.9 ± 0.7) points vs. (4.8 ± 1.3) points, t = 8.707, P < 0.001]. Hospital stay in the observation group was significantly shorter than that in the control group [(4.3 ± 1.0) d vs. (6.5 ± 1.5) d, t = 8.249, P < 0.001]. Pure tone hearing thresholds at 1, 2 and 4 kHz frequencies in the observation group were significantly higher than those in the control group (all P < 0.05). Patient satisfaction regarding the aesthetic effect of the surgical incision in the observation group was significantly higher than that in the control group [97.8% (45/46) vs. 77.8% (35/45), χ2 = 8.604, P = 0.003]. Conclusion:Endoscopic myringoplasty has the advantages including shorter operation time, less blood loss, lower degree of pain, better hearing improvement and higher patient satisfaction over microscopic myringoplasty in the treatment of tympanic membrane perforation caused by chronic suppurative otitis media.

OBJECTIVETo compare the ultra-microscopic changes of periodontal Ruffini's corpuscle induced by different patterns of tooth movement, and investigate the influence of different changes of the periodontal mechanical environment on the periodontal mechanoreceptor.

METHODSThirty-two eight-weeks-old SD rats were divided into control group (n = 4), none-extraction group (n = 12) and extraction group (n = 12), and none-extraction group and extraction group were further divided into three subgroups, namely 3 day and 14 day and 28 day. For control group, no intervention was performed. For none-extraction group and extraction group, the following interventions were conducted. In none-extraction group, the maxillary left and mandibular right third molars were moved distally. In extraction group, the maxillary left third molar was moved distally, and the bilateral mandibular third molars were extracted. The ultra-structures of periodontal Ruffini's corpuscle in the periodontal ligament of the distal root of the bilateral maxillary third molars were observed under the transmission electron microscope.

RESULTSThe ultra-structrural changes in the none-extraction group were mainly characterized by degeneration or abnormal distribution of mitochondria in the axon terminal, which were almost recovered at 28 d. In the extraction group, the changes were mainly characterized by deficiency or abnormal elongation of the Schwann sheath and were not recovered at 28 d.

CONCLUSIONSThe ultra-structures of periodontal Ruffini's corpuscle might be influenced by tooth movement and occlusal changes, and the mechanorecepting function of it might be affected by changes of the periodontal mechanical environment.

Animals ; Mechanoreceptors ; physiology ; Molar ; Molar, Third ; Periodontal Ligament ; Rats ; Tooth Movement Techniques ; Tooth Root