1.CENTRAL LOCALIZATION OF PARASYMPATHETIC PREGANGLIONIC NEURONS PROJECTING TO THE DIFFERENT PARTS OF THE RAT STOMACH
Acta Anatomica Sinica 1953;0(01):-
By using a highly sensitive HRP-TMB method, the present study found parasympathetic preganglionic neurons innervating rat stomach originated from the dorsal motor nucleus of the vagus(DMV), ambiguus nucleus(AM), reticular formation between DMV and AM(RF). rostroventrolateral reticular nucleus (RVL), lateral parvocelluler reticular nucleus (LRP), paraependymal nucloeus of the vagus (PEV), intercalated nucleus(IC) and retroambiguus nucleus(RA). There was a specific representation area of the stomach in the DMV between 0.3-0.6mm rostral to obex, and the different parts of the stomach had topographical organization within this area. The lateral portion of the DMV mainly innervated the forestomach, the medial and medial-middled portion of the DMV predominantly projected to the antrum/pylorus and corpus, respectively. The right and the left DMV did not show difference in innervating the forestomach and antrum/pylorus, but the corpus was mainly innervated by the right DMV. RF only projected to the forestomach and the corpus. RVL and RA only innervated the forestomach. AM, PEV and IC innervated all the three parts. The relationship between the different neuronal types of the DMV and the different parts of the stomach was first discussed in this paper. The forestomach, corpus and antrum/pylorus received their inputs mainly from the large and small neurons, respectively. The dentrites of the DMV contacting CSF were confirmed.
2. Combined anluohuaxianwan and entecavir treatment significantly improve the improvement rate of liver fibrosis in patients with chronic hepatitis B virus infection
Liang MIAO ; Wanna YANG ; Xiaoqin DONG ; Zhanqing ZHANG ; Shibin XIE ; Dazhi ZHANG ; Xuqing ZHANG ; Jun CHENG ; Guo ZHANG ; Weifeng ZHAO ; Qing XIE ; Yingxia LIU ; Anlin MA ; Jun LI ; Jia SHANG ; Lang BAI ; Lihua CAO ; Zhiqiang ZOU ; Jiabin LI ; Fudong LYU ; Hui LIU ; Zhijin WANG ; Mingxiang ZHANG ; Liming CHEN ; Weifeng LIANG ; Hui GAO ; Hui ZHUANG ; Hong ZHAO ; Guiqiang WANG
Chinese Journal of Hepatology 2019;27(7):521-526
Objective:
To explore the improvement rate of liver fibrosis in patients with chronic hepatitis B virus infection who received entecavir alone or in combination with anluohuaxianwan for 78 weeks.
Methods:
Patients with chronic HBV infection were randomly treated with entecavir alone or in combination with anluohuaxian for 78 weeks. Ishak fibrosis score was used for blind interpretation of liver biopsy specimens. The improvement in liver fibrosis condition before and after the treatment was compared. Student's t test and non-parametric test (Mann-Whitney U-Test and Kruskal-Wallis test) were used to analyze the measurement data. The categorical variables were analyzed by Chi-square test method and Spearman’s rank correlation coefficient was used to test bivariate associations.
Results:
Liver fibrosis improvement rate after 78 weeks of treatment was 36.53% (80/219) and the progression rate was 23.29% (51/219). The improvement of liver fibrosis was associated to the degree of baseline fibrosis and treatment methods (