1.A ten-year retrospectively analysis on occupational health damage of Indium Smelters.
Shi-qiang JIANG ; Shi-wen HUANG ; Qi-rong LIANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(10):763-764
Back Pain
;
epidemiology
;
Cohort Studies
;
Female
;
Humans
;
Indium
;
Life Tables
;
Low Back Pain
;
epidemiology
;
Male
;
Metallurgy
;
Occupational Health
;
Pneumoconiosis
;
epidemiology
;
Prevalence
;
Retrospective Studies
2.Time interval between first ever and recurrent stroke in a population hospitalized for second stroke: A retrospective study
Rong Zhu ; Ke Xu ; Jingpu Shi ; Qi Yan
Neurology Asia 2016;21(3):209-216
Objectives: The survivors of first-ever stroke are at a high risk of recurrent stroke. The time interval
between first-ever stroke and first recurrence of stroke, however, have not been well studied. The aim
of the present study was to evaluate the time interval between first-ever and first recurrence of stroke
and the risk factors of stroke that were related to the length of time interval. Methods: Patients admitted
in our hospitals during 2014 with first recurrence of stroke were included in the study. A total of 377
patients were enrolled and a standardized questionnaire was used to collect data in this retrospective
study. Results: The mean time interval among all the subjects was 58.42 months (median, 36.01 months;
range 0.16months to 455.98months). The mean time interval was shorter in hemorrhagic stroke group
(56.78 months) than in ischemic stroke group (58.75 months), but the difference was not significant
(p=0.819). The median of time interval was similar in the two groups. The associated risk factors to
the length of time interval were age over 60 years, subtype of first-ever stroke, the length of history
of hypertension. Age was the only associated risk factor to the time interval among patients with first
recurrence of hemorrhagic stroke.
Conclusion: Factors associated with the time interval are different among different types of recurrent
stroke. This provides the basis for preventive treatment for recurrent stroke after their first-ever stroke
Stroke
3.Virtual screening and activity study of antiviral compounds targeting inosine 5′-monophosphate dehydrogenase
Shi-bo KOU ; Rong-mei GAO ; Hong YI ; Lian-qi SUN ; Yu-huan LI ; Zhuo-rong LI
Acta Pharmaceutica Sinica 2022;57(10):3011-3018
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a key enzyme catalyzing the rate-limiting step of
4.Evaluating the effect of lumbar multifidus muscle training with ultrasonography
Jinjun SHI ; Qi GAO ; Yingyan WANG ; Weimin LI ; Rong BIAN ; Xinbei WANG
Chinese Journal of Physical Medicine and Rehabilitation 2015;37(2):131-135
Objective To evaluate the effect of lumbar multifidus muscle training on muscle thickness.Methods The morphological changes in volunteers' lumbar multifidus muscles were observed in response to 11 kinds of training.Muscle thickness was measured at rest and during contraction using ultrasonography and two examiners.The rate of change in muscle thickness and the contraction rate were calculated.Results There was no significant difference in the contraction rates determined by the two examiners using ultrasound imaging.There was no significant difference in average contraction rate between the males and females.Pairwise,there was no significant difference among contralateral leg-raising,ipsilateral leg-raising,contralateral hand-raising,ipsilateral hand-raising and contralateral leg-lifting.Pairwise,there was no significant difference among ipsilateral leg-lifting and ipsilateral arm-lifting compared with contralateral leg-lifting,contralateral arm-lifting or contralaleral lower limb-lifting.There was no significant difference between contralateral arm-lifting and ipsilateral arm-lifting.There was no significant difference between ipsilateral arm-lifting with contralateral leg-lifting and contralateral arm-lifting with ipsilateral leg-lifting.Pairwise,there was a significant difference in lumbar multifidus muscle contraction rates among these actions.Conclusion Lumbar multifidus muscle training has various effects.Muscle thickness as measured using ultrasonography can provide a basis for formulating a rehabilitation training plan.
5.Cause of death related to medical disputes in Yancheng area: a study of 60 autopsy cases.
Ming-Qi PENG ; Rong-Yu CHEN ; Lan ZHOU ; Kai-Qiao ZHANG ; Jian-Song SHI
Journal of Forensic Medicine 2014;30(2):110-111
OBJECTIVE:
To summarize the pattern and main characteristics of fatal cases related to medical disputes in Yancheng area.
METHODS:
Sixty fatal cases of medical disputes were retrospectively analyzed to elucidate the annual incidence, characters of distribution of hospitals, gender and age of the decedents, types of diseases, and cause of death.
RESULTS:
Among 60 fatal cases, most cases happened in health clinics of county, township and village. There were more males than females. The major medical specialties involved included internal medicine, surgery, gynecology and pediatrics, with the internal medicine specialty having the highest incidence.
CONCLUSION
Police institutions have advantages in investigation of these cases in their jurisdictions, which could enhance the ability of local medicolegal examination.
Autopsy
;
Cause of Death
;
Dissent and Disputes
;
Environment
;
Female
;
Forensic Medicine
;
Humans
;
Incidence
;
Male
;
Medicine
;
Police
;
Retrospective Studies
6.Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp. F49
Yu-shi CHEN ; Jia-rong LENG ; Shu-ting LIN ; Shao-yun WANG ; Yong-qi TIAN
Acta Pharmaceutica Sinica 2022;57(7):2120-2125
To study the chemical constituents from the the deep-sea fungus
7.Effect of casein and protamine on the enzymatic degradation and the orally hypoglycemic action of insulin.
Rong QI ; Qi-neng PING ; Rui-yang XU ; Yong-ping SHI
Acta Pharmaceutica Sinica 2004;39(10):844-848
AIMTo study the protection of casein and protamine against degradation of insulin (INS) by proteolysis enzymes and the effect of these two kinds of protein on the hypoglycemic action of INS solution and enteric-microspheres after administrated orally to rats.
METHODSHPLC was used to determine the remained INS in the solution of alpha-chymotrypsin and trypsin with or without casein or protamine; INS solution and enteric-microspheres were prepared and adiministrated orally to rats together with the absorption enhancer sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC). At the same time, casein or protamine or both of these two kinds of protein were administrated together in order to study their influence on the hypoglycemic effect of INS and microspheres.
RESULTSCasein had a good protection against degradation of INS by alpha-chymotrypsin, but protamine had no protection effect. However, the degradation of INS by trypsin is concerned, the protection effect of protamine on INS was better that of casein. Both of protamine and casein can increase the hypoglycemic effect of INS solution and enteric-microspheres. Co-administrated these two kinds of protein had a better effect. In addition, co-administrated with SNAC, casein and protamine, INS enteric-microspheres had a longer and more potent hypoglycemic effect than that of the solution.
CONCLUSIONCasein and protamine can increase the stability of INS in the intestinal fluid by the mechanism of competition and combine with proteolysis enzymes, which will benefit to INS oral administration.
Administration, Oral ; Animals ; Blood Glucose ; metabolism ; Caprylates ; Caseins ; pharmacology ; Chymotrypsin ; antagonists & inhibitors ; Drug Delivery Systems ; Hypoglycemic Agents ; administration & dosage ; pharmacokinetics ; Insulin ; administration & dosage ; pharmacokinetics ; Male ; Microspheres ; Protamines ; pharmacology ; Rats ; Rats, Sprague-Dawley ; Solutions ; Trypsin ; pharmacology
9.Effect of Chinese guidelines issued in 2001 on in-hospital management and prognosis of patients with acute myocardial infarction.
Shi-liang JIANG ; Yun ZHANG ; Xiao-ping JI ; Xiao-rong WANG ; Zhao-feng SONG ; Rong WANG
Chinese Journal of Cardiology 2005;33(9):779-781
OBJECTIVETo evaluate the effect of Chinese guidelines issued on December 2001 on in-hospital management and prognosis of patients with acute myocardial infarction.
METHODSA retrospective study was carried out in patients hospitalized in our hospital with acute myocardial infarction from January 1994 to December 2004.
RESULTSThere were 1783 patients enrolled in our study. Reperfusion therapy was undergone in 21.7% of patients hospitalized between 1994 and 2001, and in 35.8% of patients hospitalized between 2002 and 2004 (P < 0.001). Beta-blockers, ACE inhibitors and/or angiotensin receptor blockers, lipid regulating agents and antithrombins were used more extensively between 2002 and 2004 than before (all P < 0.001). There were no significant differences in the usage of nitrates and antiplatelets before and after the guidelines was issued (98.8% vs 97.9%, P = 0.172; 97.4% vs 98.6%, P = 0.113 respectively). After the guidelines issued, the incidence of angina pectoris, heart failure and death in hospital were lower than before (32.2% vs 41.2%, P < 0.001; 17.2% vs 26.2%, P < 0.001; 6.4% vs 9.4%, P = 0.038).
CONCLUSIONSChinese guidelines issued on December 2001 have great effect on the management and prognosis of patients with acute myocardial infarction. After the guidelines was issued the management became more standardized and the incidence of in-hospital complications was lower than before.
Aged ; China ; Female ; Guidelines as Topic ; Humans ; Inpatients ; Male ; Middle Aged ; Myocardial Infarction ; diagnosis ; therapy ; Prognosis ; Retrospective Studies
10.A cross-sectional study on the industrial noise over-limit status in Guangzhou factories.
Wei-sen ZHANG ; Wei-jia DU ; Zhi WANG ; Shi-qi MAI ; Qi-rong XU ; Yi-min LIU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(3):216-219
OBJECTIVETo investigate the industrial noise over-limit status of the worksites in Guangzhou factories, so as to promote the prevention and control of occupational noise hazards.
METHODS211 factories in Guangzhou were monitored and investigated. The analysis and assessment were developed for the properties and size of the factories, the districts of the factories being located, the industries of the factories being classified and the date of monitoring.
RESULTSIn this understudied factories, most of them were national-owned and joint-ventures, medium size, located in urban, and mainly involved in the industries of manufacturing of motor vehicle, shipping, electron and electric equipment, and the industries of petroleum and chemicals. The prevalence of noise over-limit was higher in joint-ventures (36.0%) and private-run enterprises (31.2%). The over-limit status mainly presented in industries of textile, food and beverage processing, and leather producing, with getting prevalence of over-limit 46.7%, 43.1% and 41.3% respectively. Subsequence were industries of manufacturing of electron and electric equipment, motor vehicle and shipping, and industries of printing and goods producing for culture and sports, with the prevalence for all > 35%. Factories monitored during spring and summer also had higher prevalence of noise over-limit. The similar results were got after adjustment for each other using multivariable regression. The most common over-limit sites mainly focused on the operation of cutting and sawing, milling and planing, pressing, riveting, drilling, jointing, assembling and quality inspecting in industries of mechanism processing and manufacturing, on quality inspecting and packing in industries of pharmacy and food and beverage manufacture, on spinning and scutching in textile industry, and on cleaning and maintaining as assistant jobs, and patrolling and inspecting air-press machine, ventilation machine, dynamotor and pump.
CONCLUSIONNoise in Guangzhou factories widely exists with different industries and districts. To strengthen noise occupational hazards prevention and control for the high risk districts, industries and worksites should be the key job in the future.
China ; Cross-Sectional Studies ; Industry ; Noise, Occupational ; prevention & control ; Occupational Exposure ; prevention & control ; Occupational Health ; Workplace