Occupational Health Services

To investigate the effect of autoimmune regulator (AIRE) on phagocytic clearance of apoptotic cells, a recombinant expression vector containing full-length human AIRE cDNA was transfected into 16HBE cells. After incubation with transfected 16HBE cells, engulfment of apoptotic HL-60 cells induced by camptothecin was detected by myeloperoxidase (MPO) staining. The change in the expression of Rac 1 in transfected 16HBE cells was determined by RT-PCR and Western blotting. The results showed that the phagocytosis percentage of the experimental group, the mock transfection group and the negative control group (non-apoptotic cells) was (25.50+/-3.67)%, (6.25+/-1.58)% and (1.0+/-0.67)%, respectively. Moreover, the expressions of Rac 1 mRNA and protein were up-regulated in AIRE-transfected 16HBE cells, suggesting that AIRE may function as a regulator in the phagocytic clearance of apoptotic cells by promoting the expression of Rac 1.

Objective:To investigate the present situation of medical students′medical ethics education and fur-ther to put forward countermeasures for medical colleges and universities. Method:With the methods of question-naire, literature and interview, medical students of the second grade and above in Xi′an Jiaotong University, Xin-jiang University and Xinjiang Medical University were investigated. SPSS 20. 0 was used to establish a database and frequency analysis method was used to analyze data. Results:It is suggested that some medical students′ motiva-tion to be a doctor is pure and the professional ethical identity is correct. There exist problems in the evaluation of ethics anomie behaviors. The students lack of cognition of medical ethics but pay more attention to medical technol-ogy. Most of the medical students think that clinical practice education and the model demonstration of teachers are conducive to medical ethics education. Conclusion: Universities can develop their own medical ethics education mode through various forms of classroom education, the involvement of old professors in teaching, strengthening learning of medical laws, daily ideological education by counselors and the construction of campus spiritual civiliza-tion.

0.05).No correlation was found between phosphate concentration and dft, dfs or CSI. Conclusions: There is no correlation between phosphate conc entration and caries status.

Objective:To explore the curative effect of Penumbra retrograde semi-retrieval Solitaire stents technique in the treatment of acute basilar artery occlusion.Methods:The clinical data of 15 patients with acute basilar artery occlusion in Shengjing Hospital of China Medical University from January 2017 to December 2019 were analyzed retrospectively. All patients were treated with Penumbra retrograde semi-retrieval Solitaire stents technique. The modified thrombolysis in cerebral infarction (mTICI) was used to evaluate the therapeutic effect.Results:Fifteen patients achieved vascular recanalization of occluded basilar artery, and mTICI 2b grade was in 3 cases, 3 grade in 12 cases. One operation completed vascular recanalization in 11 cases, 2 times in 3 cases,3 times in 1 case. CT images 24 to 48 h after operative showed no intracranial hemorrhage. The National Institutes of Health stroke scale (NIHSS) score at discharge was significantly lower than that before surgery: (4.8 ± 2.1) scores vs. (16.1 ± 5.7) scores, and there was statistical difference ( P<0.01). Conclusions:Penumbra retrograde semi-retrieval Solitaire stents technique can improve the efficiency of thrombus grasping and significantly improve patient symptoms.

Objective To investigate the change of serum CA724, CA242 and AFP levels before and after transcatheter artery chemoembolization (TACE) treatment of primary hepatic carcinoma(PHC)patients as well as its clinic significance. Methods Patients of PHC (n=45) and healthy adults (n=40) were enrolled. Serum samples were collected from each healthy people and PHC patients 2 days before TACE,l week and 1 month after TACE. Electrochemiluminescence Immunoassay (ECLI) was used to determine serum CA724, CA242 and AFP levels, and correlations among three indexes as well as their relationships with clinical data were also analysed., Change of serum CA724 and CA242 levels before and after TACE were compared in AFP<400μg/L group and AFP≥400μg/L group. Results Serum levels of CA724, CA242 and AFP in PHC group were significantly higher than that in healthy control groups before TACE therapy(P<0.05). Positive rates of serum CA724 and AFP were higher in PHC group(P<0.01)than that in healthy control group. AFP decreased significantly at both 1 week and 1 month upon TACE treatment compared with that at before teratment(P<0.01). CA724 was significantly lower at one month after treatment than that at before treatment(P<0.05). But there was no significant difference in CA242 before and after treatment(P>0.05). CA724 and AFP expressions are associated with tumor size(P<0.05). After one month of therapy, serum CA724 level was obviously decreased in both AFP<400μg/L and AFP≥400μg/L groups. Before and after TACE therapy, there was a positive correlation between the expression of AFP and CA724(r=0.754,P<0.05). Conclusion Serum CA724 can be used as one of the tumor markers to assist the evaluation of curative effect of TACE on PHC.

Objective To evaluate the value on screening of diabetic retinopathy with digital fundus photography.Design Prospective observational case series.Participant Consecutive 108 patients with typeⅠand typeⅡdiabetes mellitus,without proliferat- ed diabetic retinopathy determined by dilated ophthalmoscopy in Beijing Tongren Hospital.Methods All the patients received six-fields color fundus mydriatic photography after mydriasis and fundus fluorescein angiography.Diagnosis and grading were made based on fun- dus photography of one-field,two-fields,and six-fields.Fundus fluorescein angiography served as the reference standard.Main Out- come Measures Sensitivity,specificity and kappa value of kappa analyses.Results In comparison with fundus fluorescein angiography, if taking mild nonproliferative diabetic retinopathy as referable diabetic retinopathy,one-field fundus photography gave a sensitivity of 73.21%,a specificity of 88.64%,and a kappa statistic of 0.46,while two-fields fundus photography gave a sensitivity of 75.00%,speci- ficity of 86.36%,and a kappa statistic of 0.47,and the six-fields fundus photography gave a sensitivity of 76.05%,specificity of 87.80% and a kappa statistic of 0.48.If taking moderate nonproliferative diabetic retinopathy as referable diabetic retinopathy,one-field fundus photography gave a sensitivity of 72.46%,a specificity of 93.01%,and a kappa statistic of 0.68,while two-fields fundus photography gave a sensitivity of 73.91%,specificity of 93.01%,and a kappa statistic of 0.69,and the six-fields mydriatic digital photography gave a sensitivity of 75.36%,specificity of 92.81% and a kappa statistic of 0.70.In comparison with six-fields fundus photography,one-field fundus photography gave a kappa statistic of 0.97.Conclusion One-field mydriatic digital fundus photography centered at fovea for screening of early diabetic retinopathy especially stage DR2 or more severe is feasible

Objective To discuss the clinical manifestation and treatment of the complications caused by injected polyacrylamde hydro-gel( PAAG) for breast augmentation. Methods This retrospective research was performed among 212 patients who undergoing breast aug-mentation with injected polyacrylamde hydrogel. The clinical manifestation and treatment outcome of the complications were analyzed and summarized,which is aim to search an effective treatment method. Results For the 212 patients,the main complications were breast multi-ple indurations (131 cases),fever (9 cases),infection (14 cases),breast pain (65 cases),PAAG displacement (28 cases) and secondary deformity or asymmetry (25 cases). 152 cases experienced one clinical symptom,the rest patients simultaneously undergone no less than two clinical symptoms. Patients were received open operation with periareolar incision ( surgery group) or vacuum absorption by needle ( aspira-tion group) for dislodging PAAG. No significant difference was found in wound healing,breast shape satisfaction and pain anesis between the two groups. Whilethe surgery group was better than the aspiration group in efficiency for taking out PAAG and the incidence of reoperation, with statistical significance. Conclusion A plenty of complications occurred after breast augmentation with injected polyacrylamde hydrogel, the method of open operation with periareolar incision is a better way for eliminating PAAG and treating the complications.

Private cloud is an internal cloud featuring multi-tenant,dynamic configuration and optimization infrastructure,which enables developers to achieve service self-deployment and self-hosting within security coverage of the enterprise data center.This paper introduced the concept of cloud computing.Then it went on to present the private cloud architecture of the hospital by analysis of problems in the hospital including information construction costs,management and maintenance,and information expansion.In the end,the authors analyzed the cloud computing service model,hospital private cloud architecture,along with outcome analysis for hospital private cloud implementations.

Objective To assess the prevalence of the metabolic syndrome (MS) in Shanghai adults according to the criteria of the US National Cholesterol Education Programme Adult Treatment PanelⅢ ( NCEP ATP Ⅲ) definition. Methods Randomly selected adults were studied by means of stratified sampling. A cross-sectional study was conducted in Shanghai with a representative sample of 7 414 Chinese adults aged 35-74 years.Results Defined by the ATPⅢ criterion, the preliminary prevalence of MS was 19.81%. The prevalence of MS was 16.21% (95%CI 15.37%-17.05% ) after age was adjusted. The prevalence of MS was higher in female than in male (22.59% vs 16.64% ,P<0.01 ), and higher in urban than rural residents( 17.43% vs 17.16% ,P<0.01 ). The prevalence of MS increased with age in both male and female, especially in females aged above 55 years. There were 19.81% subjects with over 3 risk factors. The most common combination of four components in MS were central obesity, high triglyceridemia, low high-density lipoprotein-cholesterol and hypertension. Conclusions There is a high prevalence of MS in Shanghai adults. MS is increasingly becoming a noteworthy health problem. Early-diagnosis and integrated-methods of prevention and treatment of MS are mandatory.