Humans ; Infant, Newborn ; Meconium ; Peritonitis ; etiology

Child ; Humans ; Hypertension, Pulmonary ; complications ; Male ; Pulmonary Heart Disease ; complications ; Sleep Apnea, Obstructive ; complications

Objective: To investigate the chemical constituents of Dendrobium nobile from Guizhou province. Methods: The constituents were isolated and purified by silica gel, MCI column chromatography, and preparative HPLC technology. The structure of the isolated compound was elucidated by MS and NMR spectra. Results: A new sesquiterpene, identified as δ-cadinen-12,14-diol (1), was isolated from the stem of D. nobile. Conclusion: Compound 1 is a new compound.

Objective: To further study the chemical constituents of Gymnotheca chinensis. Methods: The compounds were isolated and purified by silica gel column chromatography and preparative HPLC, and their structures were elucidated by spectral analysis. Results: Sixteen compounds were isolated and identified as 2-(1-hydroxy-4-oxo-cyclohexa-2,5-dienyl)-acetonitrile (1), N-benzoyl-2-hydroxyltyramine (2), N-benzoyltyramine (3), N-benzoyl-2-phenylethylamine (4), 7,4'-dimethoxykaemferol (5), nobiletin (6), tangeretin (7), curculonone A (8), 6-hydroxy-4,7-megastigmadien-3,9-dione (9), 5,6-epoxy-3-hydroxy-7-megastigmen-9-one (10), 9-hydroxy-4-megastigmen-3-one (11), 9-hydroxy-4,7-megastigmadien-3-one (12), loliolide (13), 6β-hydroxy-stigmasta-4-en-3-one (14), 6β-hydroxy- stigmasta-4,22-dien-3-one (15), and 3β-hydroxy-stigmasta-5-ene-7-one (16). Conclusion: Compounds 1 and 2 are new natural products, and the others are isolated from this genus for the first time.

Objective: To further study the chemical constituents of Clematoclethra scandens subsp. actinidioides. Methods: The compounds were isolated and purified by chromatographic methods such as silica gel column chromatography and preparative HPLC, and their structures were identified on the basis of physicochemical properties and spectral data. Results: Nineteen compounds were isolated and identified as vulgarsaponin A (1), 9-hydroxy-megastigma-4,7-dien-3-one-9-O-β-D-glucopyranoside (2), kaempferol-3-O- α-L-rhamnpyranoside (3), quercetin-3-O-α-L-rhamnopyranoside (4), quercetin-3-O-β-D-glucopyranoside (5), hyperoside (6), 1,3,6-tri-O-galloyl-β-D-glucopyranoside (7), 1,2,3,6-tetra-O-galloyl-β-D-glucopyranoside (8), catechin (9), gallocatechin (10), procyanidin B3 (11), protocatechuic acid (12), syringic acid (13), vanillic acid (14), 7-oxokaurenolide (15), stigmast-3,6-dione (16), stigmast-4-en-3,6-dione (17), taraxerol (18), and β-sitosterol (19). Conclusion: Compounds 1-12, and 16 are isolated from the plant of Clematoclethra Maxim. for the first time.

The factor VIII gene is located on the X chromosome,making haemophilia A, a sex-linked disorder. Thus on pedigree grounds all daughters of such patients are obligate carriers. One female case of haemophilia A was reported and related literatures were reviewed.
Child ; Chromosomes, Human, X ; Epistaxis ; etiology ; genetics ; Factor VIII ; Female ; Hemophilia A ; complications ; genetics ; Humans

Adenocarcinoma, Clear Cell ; Female ; Humans ; Middle Aged ; Nasal Cavity ; Nose Neoplasms

OBJECTIVETo observe therapeutic effects of locking titanium plate for the treatment of comminuted proximal humeral fracture in elderly.

METHODSFrom June 2011 to May 2013, 72 elderly patients with comminuted proximal humeral- fractures were divided into locking titanium plate group and anatomical plate group, 36 cases in each group. In locking titanium plate group, there were 16 males and 20 females aged from 60 to 79 years old with an average of (69.55±5.62) years old; 10 cases were type Neer II, 18 were type Neer III and 8 cases were type Neer IV in accordance with Neer classification; treated with locking titanium plate. In anatomical plate group, there were 15 males and 21 females aged from 60 to 81 years old with an average of (69.76±5.70) years old; 9 cases were type Neer II, 20 were type Neer III and 7 cases were type Neer IV; and treated with anatomical plate. Clinical effects, preoperative and postoperative Neer scoring, operative time, bone healing time and incidence of complications between two groups were compared.

RESULTSAll patients were followed up from 1 to 3 years with an average of 15 months. The excellent and good rate of locking titanium plate group (91.7%) was significantly higher than anatomical plate group (75.0%). Postoperative Neer score of two groups were improved obviously, but locking titanium plate group (92.51±7.85) was higher than anatomical plate group (83.64±8.56); there was no significant differences between two groups in operative time (P>0.05); bone healing time in locking titanium plate was (18.6±3.4) weeks, and shorter than anatomical plate group (24.3±3.9) weeks; incidence of complications in locking titanium plate was (5.6%) shorter than anatomical plate group (22.2%), and had obviously differences between two groups.

CONCLUSIONLocking titanium plate for the treatment of comminuted proximal humeral fracture in elderly plays an important role in good rate, bone healing time and Neer score. It has advantages of early rehabilitation exercise, less shoulder pain, rapid recovery of shoulder joint, less complications, safe and effective, and be worthy of clinical application, especially for senile osteoporosis patients.

Aged ; Aged, 80 and over ; Bone Plates ; Case-Control Studies ; Female ; Fractures, Comminuted ; surgery ; Humans ; Male ; Middle Aged ; Shoulder Fractures ; surgery ; Titanium

Dietary Proteins ; administration & dosage ; Energy Intake ; Female ; Hospitalization ; Humans ; Infant, Newborn ; Infant, Very Low Birth Weight ; Logistic Models ; Male ; Parenteral Nutrition ; Weight Gain

Objective To investigate the functional and histological changes in aging gerbil bladders.MethodsTwelve male gerbils were randomly divided into control group and aging bladder group,with 6 in each group.Experiment was conducted in gerbils of control group and aging bladder group 6 months and 24 months after normal feeding,respectively.Urodynamic examinations including irrigation volume,compliance and filling pressure of bladder were performed,bladder weight was obtained,bladder weight index was calculated,morphological observation was conducted with HE staining,ratio of amount of smooth muscle to collagen was obtained with double immunohistochemical staining,and electron microscope was used to evaluate the ultrastructure of bladder.ResultsCompared with those in control group,the irrigation volume and compliance of bladder significantly decreased in aging bladder group(P0.05).However,the bladder weight index was significantly lower in aging bladder group(P0.05).There existed degeneration in smooth muscle cells and organelles in aging bladder group.ConclusionThe function of aging bladder in gerbils is impaired,which may be related to the degeneration of bladder tissues.