OBJECTIVE To evaluate the significance of transnasal endoscopic optic decompression in traumatic optic neuropathy. METHODS Four patients with blindness from traumatic optic neuropathy were treated with transnasal endoscopic optic decompression. RESULTS Two patients improved in visual acuity to CF/50 cm and light perception. Two patients didn’t improve after surgery. CONCLUSION Transnasal endoscopic optic decompression is significant in the management of traumatic optic neuropathy due its effectiveness and minimal invasiveness. It’s implications can be enlarged under some circumstances.

Child ; Chromobacterium ; Female ; Humans ; Sepsis ; drug therapy ; etiology ; microbiology ; mortality

The present study is designed to investigate the histochemical changes of cholinesterase, norepinephrine in nuc. Supraopticus and locus coeruleus of rats following electo-acupuncture and their possible relation to pain threshold. The preliminary results indicated that the elevation of pain threshold following electro-acupuncture concomittantly with increase in histochemical reaction of cholinesterase, and norepinephrine both in nuc. Supraopticus and locus coeruleus of electro-acupunctured rats. The increase in intensity was shown to be correlated with the elevation of pain threshold. The intensity of increased cholinesterase activity was more obvious in the animals with pain threshold elevated for above two folds than those elevated only one fold. On the other hand, the higher intensity of norepinephrine was obser ed in locus coeruleus with one fold of elevation of pain threshold. The significance of the changes in these two nuclei and their possibld function were briefly discussed.

OBJECTIVE To investigate infection of Chlamydia trachomatis(CT) and Ureaplasma urealyticum(Uu) in patients with nongonococcal urethritis(NGU). METHODS C.trachomatis was determined by fast immune method of antigen-antibody.U.urealyticum was detected by liquid culture medium. RESULTS Among 320 cases the positive rate of C.trachomatis,and U.urealyticum was 36.25% and 43.75%,respectively.and that of complicated infection was 20.00%.There were significant differences between men and women in C.trachomatis and U.urealyticum infection(P

Ovarian neoplasms,composed predominantly or exclusively of small round cells with scant cytoplasm,is relatively rare.However,there is a wide range of differentiation,and pathologists often struggle to make a correct diagnosis because of its overlapping histological features.Perhaps the best known neoplasm of this kind is ovarian small cell carcinoma of the hypercalcemic type,which may be confused with a wide range of neoplasm from sex cord-stromal tumor to neoplasm in the family of small round blue cell tumor to various undifferentiated malignancies.Small cell carcinoma of the pulmonary type may also arise from the ovary,and this may be a component of a typical ovarian surface epithelial-stromal tumor.Other small cell neoplasm that may arise within the ovary or involve the ovary includes intra-abdominal desmoplastic small round cell tumor,metastatic small cell carcinoma,peripheral primitive neuroectodermal tumor,and endometrial stromal sarcoma.In this review,the morphologic features of some of these neoplasms are described,as well the value of immunohistochemistry and other ancillary techniques in establishing a diagnosis.

Investigation of simvastatin and its related substances was carried out using a reversed phase ultra performance liquid chromatography/tandem mass spectrometry method. The identification of impurities in simvastatin was performed with a triple-quadrupole mass spectrometer, with an electrospray ionization (ESI) source in the negative/positive ion mode. A total of 12 compounds were characterized in commercial samples, among which 2 impurities had never been reported. All the impurities were deduced based on the MS fragment pathways of simvastatin and the biosynthetic pathway of lovastatin. This work provides very useful information for quality control of simvastatin.

Objective To compare the efficacy of minimally invasive pereutaneous nephrosomy for complicated renal calculi between holimium laser hthotfipsy and ultrasonic lithotripsy.Methods 120 patients with renal calculi according to the different treatment methods,were divided into holimium laser lithotfipsy group 60 cases(group A)and tdtrasonic lithotripsy group 60 cases(group B).The index of operative time、hemoglobin drop blood transfusion rate、postoperative hospital stay、stone clearance rate were observed.Results Operative time(60.8±16.4)min,postoperative hospital stay(7.5±2.0)d in group A were shorter than[(80.5±18.5)min,(9.5±2.5)d]in group B (t=2.328,2.240,all P＜O.05);Hemoglobin decline(5.0%)in group A was lower than the(9.0%)in group B (x2=3.89,P＜0.05);Calculi clearance rate(81.7%)in the B group was highter than that(61.6%)in group B (x2=3.98,P＜0.05);Complication incidence of postoperative 10.O%in group A compared with group B 13.3%had no significant difference(x2=1.56,P＞0.05).Conclusion Percutaneous nephrostomy with ultrasonic lithotripter for complicated renal calculi had the advantages of mini-invasion,less operative time,less bleeding,and faster clearance calculi efficiency compared with laser lithotripsy.

Tolvaptan is a novel oral selective arginine vasopressin V2 receptor antagonist.Tolvaptan improves heart failure signs and symptoms without serious adverse events.Tolvaptan has no effect on all-cause mortality and cardiovascular death or admission rate for heart failure.But in heart failure patients with hyponatremia,tolvaptan can decrease cardiovascular death and admission rate for heart failure.

Objective To observe the clinical effect of edaravone combine with clopidogrel on patients with acute cerebral infarction . Methods Eighty cases diagnosed with acute cerebral infarction from February 2014 to February 2015 were randomly divided into observation group and control group with 40 cases in each group.Control group received basic treatment of clopidogrel, observation group received edaravone on the basis of control group.The serum levels of superoxide dismutase ( SOD ) and malondialdehyde ( MDA ) between two groups were compared post-treatment. Results The serum SOD levels in observation group on 7th and 14th day post-treatment [(89.37 ±6.07, 99.14 ±11.24)U/mL]were significantly higher than those in control group [(71.26 ±7.43,80.01 ±12.02)U/mL](P<0.05).The serum MDA levels in observation group on 7th and 14th day post-treatment [(5.23 ±0.81, 3.42 ±0.48)nmol/mL]were significantly higher than those in control group[(7.16 ±1.01,5.24 ±0.71) nmol/mL](P<0.05).Conclusion Edaravone combined with clopidogrel has the exact effect in treatment of patients with acute cerebral infarction.

Objective To investigate the prenatal or intrapartum risk factors,resuscitation and its outcomes among full term but dying newborns after severe asphyxia (Apgar score was 0～1 at 1 min after birth).Methods Totally,39 dying full-term newborns,who were admitted to the neonatal intensive care unit of Shenzhen Maternity&Child Healthcare Hospital,Southern Medical University from January,2003 to June,2014 were analyzed retrospectively.Information on perinatal influencing factors and outcomes of resuscitation were collected and analyzed with Chi-square test.Results All of the babies were divided into died (n=7,18％,one refused to further treatment) and survived group [n=32,among which 15 suffered from hypoxic-ischemic encephalopathy(HIE) (seven mild,seven moderate and one severe case)].Fetal heart beat was undetectable in more babies in the died group than in the survived group [2/7 vs 0％(0/32),x2=4.695,P=0.028].There were 19 infants with Apgar score ≤ 5 at 5 min,and seven of them died (7/19).The other 12 survived with HIE occurred in eight cases (four mild,three moderate and one severe case) and the rest four babies did not report any neurological complications.Among the ten infants with Apgar score ≤ 5 at 10 min,seven died or refused to treatment and the other three survived with moderate HIE.Conclusions Most of the dying term babies may have promising outcomes after effective resuscitation,especially for those with Apgar score over 5 at 5 min.However,for those dying term babies with Apgar score remains ≤ 5 at 5 min,management after resuscitation should be strengthened to reduce the occurrence of any sequelae or complications.