1.Changes of oxygen function of workers of long-term exposure of toluene, methanol, dimethylformamide.
Yu-feng LOU ; Xin-ping SHI ; Li-jian LOU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(7):527-528
Adult
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Dimethylformamide
;
adverse effects
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Glutathione
;
blood
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Humans
;
Male
;
Methanol
;
adverse effects
;
Nitric Oxide
;
blood
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Occupational Exposure
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Oxygen
;
metabolism
;
Superoxide Dismutase
;
blood
;
Surveys and Questionnaires
;
Toluene
;
adverse effects
3.Infect of pingshen decoction on serum HGF, Cys C and TGF-beta1 diabetic nephropathy in early stage.
Hui-Lan BAO ; Shang-He YE ; Shi-Xian LOU ; Xiao-Wen LU ; Xiang-Feng ZHOU
China Journal of Chinese Materia Medica 2014;39(6):1128-1131
Study the serum level of HGF, Cys C and TGF-beta1 in type 2 diabetic nephropathy (DN), the infect of Pingshen decoction on those index. Selected 69 cases of 2 type DN and randomly divided into therapy group (36 cases) and control group (33 cases). The therapy group were treated with Pingshen decoction 1 dose/d, bid po. The control group were treated with NephritisShu tablet, 6 tablet, tid po. 8 weeks was a course. Before and after treatment, we examine the serum level of HGF, Cys C and TGF-beta1 by ELISA and immunonephelometry, and compare with 30 cases of healthy control group. The study demonstrates that before treatment, the serum level of HGF in both groups were significantly lower than healthy control group (P < 0.01), but Cys C, TGF-beta1 were significantly higher (P < 0.01). After treatment, the serum level of HGF of both groups were increased. The serum level of HGF of therapy group were significantly higher than of control group (P < 0.01), but the serum level of Cys C and TGF-beta1 were significantly lower than control group (P < 0.01). The serum level of HGF was correlated negatively with Cys C,TGF-beta1. In control group, the UAER, urine beta2-MG and quantity of 24-hour urine protein were significantly decreased after treatment (P < 0.01). The index of urine of therapy group were significantly lower than control group (P < 0.01). Results indicate that test of serum level of HGF and Cys C,TGF-beta1 of diabetic nephropathy have important clinical significance. Pingshen decoction can effectively intervene in the serum level of HGF and Cys C, TGF-beta1 and index of urine.
Aged
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Aged, 80 and over
;
Case-Control Studies
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Cystatin C
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blood
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Diabetic Nephropathies
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blood
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drug therapy
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Drugs, Chinese Herbal
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adverse effects
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therapeutic use
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Female
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Hepatocyte Growth Factor
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blood
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Humans
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Male
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Middle Aged
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Transforming Growth Factor beta1
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blood
4.Nursing of children patients with cochlear implantation for prevention of frontal pressure sores
Hao LOU ; Chen ZHOU ; Jianxia FENG ; Jing XIN ; Manli SHI ; Yu HE
Chinese Journal of Practical Nursing 2015;31(10):748-750
Objective To discuss nursing ways to prevent frontal pressure sores for children after cochlear implantation.Methods A total of 267 cases with sensorineural deafness were selected and divided into the control group (admitted from December 2012 to July 2013,115 cases) and the observation group (admitted from August 2013 to March 2014,152 cases) randomly.Skin preparation was done routinely,general nutritional condition and frontal skin condition were evaluated before operation.The control group used conventional elastic bandage after surgery.The observation group used Allevyn Thin foam dressing to cover the forehead skin before pressure dressing by elastic bandage.The incidence of frontal pressure sores was compared between two groups.Results Two cases occurred frontal pressure sores in the observation group and 31 cases in the control group,x2=39.736,P < 0.01.Patients in the control group with pressure sore focused within 1-2 years old,totally 18 cases.Conclusions Nurses should attach great importance to younger children with cochlear implantation to prevent pressure sores.Nursing staff should keep update knowledge of prevention and treatment of pres-sure ulcers,accurately assess skin conditions and risk factors in patients and adopt precautions predictably.
5.Study on the pulsed electromagnetic fields promoting cure of plateau stress ulcer
Mingke JIAO ; Jing FENG ; Lin LOU ; Peng ZHANG ; Xiliang GENG ; Saidazimu YIMITI ; Yanhui SHI
Chinese Medical Equipment Journal 2017;38(5):36-38
Objective To determine the effects of non-thermal biological effect of low frequency pulsed electromagnetic field (LFPEF) with 15 Hz and 30 mT on ulcer wound during the plateau stress ulcer cure.Methods Thirty male Sprague-Dawley rats were assigned to three equal groups:control,normal cure group (NC) and exposure treatment groups (ET).The plateau rats stress ulcer models were constructed with the combination method of a hypoxic and low-pressure acclimation and the stimulation of absolute ethyl alcohol irrigating stomach.The LFPEF equipment generated the LFPEF of 15 Hz,40% duty cycle and 30 mT to expose and treat the rats' stomach of ET group with the frequency of 3 hours each day.After 6 days of exposure treatment,the stress ulcer cure situation of each group was evaluated by the methods of macroscopic observation,the gastric juice pH values detection and ulcer index (UI) measurement.Results After 6 days of model,the macroscopic observation showed that the ulcer of NC group was worse than the that of ET group (P<0.05).The pH values and UI of ET group were significantly different with those of NC group,and closed to those of the control group.Conclusion The nonthermal biological effect of LFPEF could promote the plateau stress ulcer cure.
6.Ultrasonic Characteristics of Urinary Calculus in Infants with History of Feeding Melamine Contaminated Milk Powder
jian-guo, WEN ; jin-hua, HU ; an-feng, LOU ; yan, WANG ; jian-min, CHANG ; shi-cheng, QIN ; rui-fang, ZHANG
Journal of Applied Clinical Pediatrics 1986;0(01):-
Objective To summarize the ultrasonic characteristics of urinary calculus in infants who had history of feeding melamine contaminated milk powder.Methods A total of 163 children[aged(19.4?10.9)months] with urolithiasis,who had feeding melamine contaminated milk powder,were retrospectively analyzed using ultrasonography.Twenty children [aged(16.7?9.9)months] with urolit-hiasis,who had no feeding history of melamine contaminated milk powder,were chosen as controls.Ultrasonic characteristics were compared between the 2 groups.Results For melamine calculus cases,sporadic spot or hyperechic mass with different size and shape in the collecting system,partly without acoustic shadow,was found in 65 cases;dense echo and luminous belt with obscured acoustic shadow under a band without echo was found in 48 ureteral calculus cases;irregular strong echo mass or small spot with thick acoustic shadows without side lobe artifact in the dark liquid areas was found in 8 cases with bladder calculus.There was significant difference in morphology of the calculus(P0.05).Conclusions The unique ultrasonic characteristics in infants with melamine calculus had become a very useful tool to diagnose the pediatric urinary melamine calculus.J Appl Clin Pediatr,2009,24(1):67-69
7.Influencing factors for occupational stress among frontline employees in a chemical fiber manufacturing enterprise
WANG Jianfei ; JIN Mingying ; ZHU Ye ; FENG Lingfang ; XIA Hailing ; LI Tao ; CHEN Junfei ; FANG Yuan ; SHI Li ; LOU Jianlin
Journal of Preventive Medicine 2022;34(1):6-10
Objective :
To investigate the status of occupational stress and analyze its influencing factors among frontline employees working in a chemical fiber manufacturing enterprise, so as to provide insights into the development of occupational stress interventions.
Methods :
The frontline employees working in a chemical fiber manufacturing enterprise were selected as the study subjects using a cluster sampling method in October 2018. The status of occupational stress was investigated using the Chinese version of the effort-reward imbalance ( ERI ) questionnaire. The influencing factors for occupational stress were identified using a multivariable logistic regression model.
Results :
A total of 1 780 questionnaires were sent out, and 1 115 valid ones ( 62.64% ) were recovered. Among the 1 115 respondents, there were 427 men ( 38.30% ) and 688 women ( 61.70% ), and 71.22% were at ages of 21 to 39 years. There were 561 respondents with < 1 year of service ( 50.31% ), and the longest length of service was 11 years. In addition, there were 1 069 respondents ( 95.87% ) exposed to high noise, and 346 respondents ( 31.03% ) were diagnosed at a high occupational-stress state and 769 ( 68.97% ) at a low state. Multivariable logistic regression analysis identified 5 years or longer of service ( OR=1.540, 95%CI: 1.057-2.245 ) and exposure to high noise ( OR=1.917, 95%CI: 1.004-3.659 ) as risk factors for occupational stress among frontline employees in the chemical fiber manufacturing enterprise.
Conclusions
There are 31.03% of frontline employees at a high occupational-stress state in the chemical fiber manufacturing enterprise, and a high occupational-stress state is associated with exposure to high noise and 5 years or longer of service.
8.Experimental study of 131I-labeled granulocyte macrophage colony-stimulating factor in SCID mouse-acute myeloid leukemia model.
Yang-jia DENG ; Shi-feng LOU ; Yi-zhi XU
Chinese Journal of Hematology 2007;28(1):33-36
OBJECTIVETo observe the therapeutic efficacy of 131I-labeled granulocyte macrophage colony-stimulating factor (GM-SCF) in SCID mouse-acute myeloid leukemia model, and the relationship between dose and effect.
METHODSSCID-mouse acute myeloid leukemia model was established by injecting HL-60 cells through tail vein. GM-CSF was labeled with 131I by the chloramines-T method. SCID mice were randomly divided into 6 groups. Groups I, II and III treatment groups were given 9.25 x 10(5), 22.20 x 10(5) and 37.00 x 10(5) Bq of 131I-GM-CSF, respectively. Group IV was given 131I. Group V was given blending of 131I and GM-CSF. Group VI was control. Changes of HL-60 cells in blood and marrow, as well as white blood cells, red blood cells and platelets in blood were detected. Survival time of the SCID mice was calculated.
RESULTIt was observed that WBC, HL-60 cells in blood and marrow were less in treatment groups than that in control groups, especially in groups II, III. After 2 weeks of treatment, BPC of II, III groups increased remarkably (P < 0.01). Survival time of the SCID mice was prolonged in treatment groups (P < 0.01), especially in group III, the longest survival time of 60 days.
CONCLUSION131I-GM-CSF could increase leukemic SCID mice survival rate. The therapeutic efficacy of low dose and mediate dose of 131I-GM-CSF is dose-dependent. 131I-GM-CSF is an effective radiation immunity therapy for leukemic mice.
Animals ; Antineoplastic Agents ; therapeutic use ; Dose-Response Relationship, Drug ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor ; therapeutic use ; HL-60 Cells ; Humans ; Leukemia, Myeloid, Acute ; drug therapy ; Mice ; Mice, SCID ; Xenograft Model Antitumor Assays
9.Study on vascular morphology of integument tissues of the channel area in the leg.
Xin-fa LOU ; Jin MEI ; Song-he JIANG ; Quan SHI ; Rui-feng ZHANG ; Mao-lin TANG
Chinese Acupuncture & Moxibustion 2006;26(9):641-643
OBJECTIVETo observe the distribution of the blood vessels in the integument tissue of the channel area of legs.
METHODSThe integument tissue of the lower limbs in the 12 cadavers were dissected with macro-and micro-dissection, radiographical technique of systemic artery and technique of image pattern analysis to observe and analyze the origins, branches and anastomoses in the integument tissues along the channels of legs.
RESULTSThe distributional density of the blood vessels in the integument tissues of legs along the channel area of the three-yin meridians of the foot, the Gallbladder Meridian, and the Urinary Bladder Meridian was higher than that in the other parts. They formed an obvious nutrient vascular chain on the arteriogram. The distributional density in the channel area of the Stomach Meridian was not obviously increased and the obvious nutrient vascular chain could not be seen.
CONCLUSIONAn obvious nutrient vascular chain is formed in the integument tissue along the channel area of legs except the Stomach Meridian.
Blood Vessels ; anatomy & histology ; Humans ; Leg ; blood supply ; Meridians
10.Biodistribution study of 131I-gM-CSF in SCID mice bearing human leukemia.
Yi-zhi XU ; Shi-feng LOU ; Yang-jia DENG
Chinese Journal of Hematology 2006;27(10):678-681
OBJECTIVETo investigate the biodistribution of 131I-GM-CSF in SCID mice bearing human AML in vivo.
METHODSThe xenograft model of human leukemia was established in SCID mice. In the leukemia mice, the biodistribution of 131I-GM-CSF produced by chlo amine-T method was studied.
RESULTS(1)The inoculated HL-60 cells could grow in SCID mice, which developed leukemia after 4 weeks. (2) 131 I-GM-CSF was concentrated in spleen, bone marrow and tumor tissue of the mice. In spleen and bone marrow, 131 I-GM-CSF was uptaken to peak in 30 minutes after injection, the up taking rate was (442. 9+/-86. 4) % ID/g and (4283. 8+/-252. 8)% ID/g, respectively, and maintained on higher level in 24 hours. The injection of 131I resulted in an even distribution in the whole body.
CONCLUSIONS131 I-GM-CSF is able to concentrate electively in spleen, bone marrow and organs infiltrated by leukemia cells. The biodistribution of 131I-GM-CSF in the leukemia mice is tissue specific.
Animals ; Female ; Flow Cytometry ; Granulocyte-Macrophage Colony-Stimulating Factor ; pharmacokinetics ; HL-60 Cells ; Humans ; Iodine Radioisotopes ; Leukemia, Myeloid, Acute ; metabolism ; Mice ; Mice, SCID ; Xenograft Model Antitumor Assays