With the improvement of endoscopic technology,an increasing number of early esophageal cancer is diagnosed by gastroscopy.Regardless of the size or submucous fibrosis of esophageal cancer,endoscopic submucosal dissection (ESD) allows en bloc resection and histologically complete resection of the tumor.ESD has been recognized as an optimal treatment modality for early esophageal carcinoma.Currently,short-term curative effects of early esophageal cancer after ESD have been proved satisfactory,but the long-term outcomes remain unclear.This paper reviews the research advances about the long-term outcomes of ESD,and focuses on the postoperative stenosis,the recurrence,metastasis and survival rates of patients,to provide treatment reference for clinicians.

Objective To observe the clinical efficacy of electroacupuncture plus puncturing the thirteen ghost points in treating diabetic gastroparesis.Method Sixty patients with diabetic gastroparesis were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture plus puncturing the thirteen ghost points, while the control group was by electroacupuncture alone. The clinical efficacies were then compared.Result The total effective rate was 93.3% in the treatment group versus 83.3% in the control group, and the difference was statistically significant (P<0.05). Conclusion Electroacupuncture plus puncturing the thirteen ghost points is an effective approach in treating diabetic gastroparesis.

Objective To systematic evaluate the prevalence of secondhand smoke among Chinese mainland rural residents by meta?analysis,so as to provide reference for making relevant smoking control regulations and the carry out of targeted tobacco control action. Methods The related stud?ies were searched and collected from PubMed,CNKI,Wanfangdata,VIP and CBM database,which were published between 2001 and 2015 about the prevalence of secondhand smoke among Chinese mainland rural residents. Meta?analysis was tested by software CMA V2. Results The pooled prevalence of secondhand smoke among Chinese mainland rural residents was 46.6%(95%CI 40.5%?52.8%). Stratified analysis showed that the prevalence of secondhand smoke were 45.7%and 47.5%for male and female,45.7%and 51.1%for eastern and midwest China,22.1%、34.2%and 71.3%for public place,workplace and family,respectively. The prevalence among sex,regions,and places were statistically significant. Conclusion The prevalence of secondhand smoke among Chinese mainland rural residents was relatively high,and the prevalence of secondhand smoke was higher in women than in men,in midwest area than in eastern area,and at family than at public place and at workplace.

Objective To improve the existing military water tank to prevent water pollution.Methods The modified water tank was composed of a lip,body,a floating ring filled with foam materials,a zipper,multi faucets,drain valve,rack and etc.The zipper on the top of the tank could close down the tank,the faucets at the lower part realized water supply,and the drain valve at the bottom discharged residual water.Results The dust,small animals and etc were prevented from going into the tank with the consumed water decreased,and the tank was easy to clean.Conclusion The tank contributes to military water supply at field conditions,and is worthy promoting practically.

Objective To evaluate the air bronchograpm in the differential diagnosis of peripheral solitary pulmonary nodule(3 cm or less) by computed tomography (CT). Methods The thin section CT images of air bronchogram in 190 eases with peripheral solitary pulmonary nodule confirmed by surgical resection and/or bronehoscopy and/or percutaneous needle biopsy and histopathology were analysed. Results The air bronchogram was seen in 52/100(52%) cases with peripheral lung cancers and in 29/50 cases (58%) with inflammatory pseudotumors on CT scans. Of lung cancers, there were adenocareinoma in 23/31 eases, squamous cell carcinoma in 14/41 cases, adenosquamous carcinom in 4/5 cases,small cell carcinoma in 7/14 cases and poorly differentiate carcinoma in 5/9 cases. The air bronchograms were not seen in 32 tuberculomas,5 hamartomas and 3 pulmonary cysts. Conclusion Air bronchogram can be seen in several pnlmonary nodules,it does not appear to be the characteristic of small peripheral carcinoma especially adenocarcinoma, and it alsc can not be helpful in distingushing malignant and benign pulmonary nodules.

Thrombolytic agents for the treatment of acute ischemic stroke have some limitations. Balloon angioplasty and stenting have become the research hotspot in the treatment of acute ischemic stroke. 1his article reviews the effectiveness and safety of balloon angioplasty and stenting in the treatment of acute ischemic stroke.

BACKGROUND:Retinal contusion injury is one of the leading causes for vision impairment, and clinical treatment is difficult. Although fundus change after retinal contusion injury has been ful y understood, the pathogenesis and drug treatment stil remain controversial.
OBJECTIVE:To explore the apoptosis and related mechanism of optic nerve cel s in rabbit model of retinal contusion injury.
METHODS:Forty-eight healthy adult rabbits without oculopathy were divided into eight groups:1 hour, 3 hours, 1 day, 3 days, 7 days, 14 days, 28 days after contusion and normal control, with six rabbits in each group. Right eye of each rabbit was treated with Al en’s reformative hitting method as contusive retinopathy model. The eyebal s were enucleated at different time points after injury in rabbit retina. The pathological section of optic nerve 5 mm posterior to sieve plate was harvested. The morphologic changes of optic nerve were observed and number of glial cel s was measured using hematoxylin-eosin staining. Electron microscope and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling technique were used to assess apoptosis.
RESULTS AND CONCLUSION:In the normal control group, glial cel s presented cylinder shapes and neural fibers arranged neatly. The trend of the glial cel s was as the same as the neural fibers. But the optic nerve fibers arranged in disorder and the glial cel s lost polarity in the groups of 1 hour, 3 hours, 1 day, 3 days, 7 days after retinal contusion injury. The number of glial cel s in 1 hour, 3 hours, 1 day, 3 days, 7 days, 14 days, and 28 days was extremely significantly reduced compared with normal control group (P<0.01). There was cel apoptosis in optic nerve after retinal contusion injury, but almost not observed in optic nerve from normal control group, 1 hour and 28 days after injury. The apoptotic cel s were abundant at 3 hours, 1 day, 3 days, 7 days, 14 days after injury, and peaked at 3 days, showing extremely significant differences compared with normal control group (P<0.01). Apoptosis occurs in optic nerve after contusion of retina, which may be one of the reasons for incomplete recovery of retinal function.

Objecive To explore modern management and optimization of hospital warehouse slotting with some class A tertiary hospital taken as an example.Methods EIQ_ABC classification method,multi-objective assignment model and genetic algorithm were used to analyze and simulate the data of 126 kinds of medical devices for 20 orders.Results The medical devices were divided into nine categories of Ⅰ A,Ⅰ B,Ⅰ C,Ⅱ] A,Ⅱ B,Ⅱ C,Ⅲ A,Ⅲ B and Ⅲ C.It's suggested that emphasized management and precision slotting storage were carried out for A categories of devices,dedicated storage for B categories and random storage for C categories.At the same time,the layout of the warehouse was optimized according to the importance of the goods so that the important goods were placed near the passageway.Slotting analog simulation diagram was obtained based on multi-objective assignment model of Ⅲ A category medical device.Conclusion Classified management and allocation as well as slotting optimization of medical devices contribute to improving hospital modern management in efficiency,cost and error rate.

The single colonel composition of pituitary adenomas of human attests to the molecular basis of pituitary tumorigenesis. This review offers a specific overview of the involvement of alternation of tumor oncogenes and tumor suppressor genes (TSGs) in the pathogenesis of human pituitary adenomas. Mutations of gsp and H ras oncogenes genes and amplification of PKC have been identified in pituitary adenomas. Especially the mutation of gsp has been detected in 40% human GH secreting pituitary adenomas. The role of TSGs(tumor suppressor genes) including MEN 1, p53, Rb and p16 in pituitary adenoma formation and progression has yet be observed. Providing evidence proves that activation of oncogenes and inactivation of tumor suppressor genes seem to be at least one mechanism by which human pituitary adenomas origin and progress.

Gastrointestinal stromal tumor (GIST) may be defined as mesenchymal tumors of the gastrointestinal tract,and the application of the tyrosine kinase inhibitor imatinib mesylate has changed the treatment style of the tumor.The surgical treatment is the only choice for the GIST patients before imatinib era,but now the individualized treatment combined with target therapy,surgery and laparoscope surery becomes the mainstay.The paper focus on the new development of preoperative biopsy,laparoscope surery,imatinib neoadjuvant and imatinib therapeutic effect evaluation in recent years.