[Objective] To explore the status of chlorite pollution in drinking water due to chlorine dioxide , aswell as its causes and counter measures. [Methods]A water plant collecting surface water as raw water slightly pol-luted by organic compounds and B water plant collecting ground water without organic compounds pollution wereselected as observed objectives. Chlorine dioxide generators were used in both of A and B water plants, their rawmaterials was chlorite for A plant and chlorate for B plant. The levels of chlorite in treated water from these twowater plants were determined by amperometric titration. [Results]The levels of chlorite in treated water of A waterplant ranged 0.530～0.760 mg/L, 2.6～3.8 times of the standard value, with a over standard rate of 100％, thelevels of B water plant range 0.257～0.733 mg/L, 1.3～3.7 times of the standard value, with a over standard rateof 83.3％. [Conclusion] The treated water of A and B water plants presented higher pollution by chlorite, the by-product of chlorine dioxide disinfection.

Protease-activated receptor-2 (PAR-2) belongs to the receptor family which is coupled with G-protein. The N-terminus of PAR-2 is cleaved by some proteases to generate a new N-terminus. The new N-terminus can interact with and activate the receptor itself. The update research reported that PAR-2 could be expressed on some cancers as well as tumor cell lines. There are some relationships between the PAR-2 expression and the behaviors of tumor cell, such as proliferation, angiogenesis, migration and invasion.

The changes in the total and differential leukocyte counts as well as glycogen con- tent and alkaline phosphatase activity of neutrophile granulocyte of peripheral blood were studied during tubal ligation through abdomen with electro-acupuncture at Zha- guan point(tubal ligation point).This work may help to detect the role of the leuko- cytes in the regulatory function of the body and its relationship to acupuncture anal- gesia.The resuhs were as follows: 50 patients undergoing tubal ligation under acupuncture anesthesia were observed. During the operation,the total number of leukocytes was increased as compared with that before the operation.In patients of grade Ⅰefficacy(35 cases)the total number of leukocytes was increased most markedly.In all patients operated under acupuncture anesthesia,the relative proportion of various types of leukocytes showed little or no significant changes,but their absolute number increased to some extent,with the excep- tion of eosinophile granulocyte of grade Ⅱpatients which decreased slightly.A cyto- chemical study of the glycogen content of neutrophil was carried out in 45 patients during acupuncture anaesthesia.The content was decreased during operation especially in 31 cases of Grade Ⅰpatients it was decreased most markedly.On the other hand,the neutro- phil alkaline phosphatase activity was increased during the operation in 20 patients. The control group of 33 cases was further divided into three subgroups.In the first subgroup,we used acupuncture anaesthesia without operation and the total number of leukocytes was decreased slightly.In the second subgroup the patients were operated under local anesthesia(2% procain solution injection subcutaneously),and the last sub- group comprised only normal adults without any operation or anesthesia.There were little or no significant changes in total and differential leukocyte counts during the experiment in th last two subgroups. The above alterations of leukocyte observed in patients operated under acupuncture anesthesia may explain the enhancement of bodily protection produced by acupuncture, by the way of the regulation effect of central nervous system.

Botulinum neurotoxin(BoNT) is the most lethal biotoxin known to mankind. It inhibits acetylcholinerelease from the cholinergic nerve ending by cleavage of SNARE proteins, followed by neuromuscular blockadeand paralysis. Gangliosides are considered to act as a first receptor of BoNT with low affinity.Then the membranebound gangliosides-BoNT complex moves laterally to reach and bind the toxin specific protein receptor,synaptotagmin, with a high affinity constant. At last the gangliosides-BoNT-synaptotagmin complex undergoesreceptor-mediated endocytosis. This double-receptors theory is widely accepted. The research data are summarizedand reviewed.

Objective To study the changes and clinical significance of P selectin (CD 62P), lysosome protein (CD 63) expression in patients with ischemic stroke.Methods 168 cases of acute ischemic stroke (both acute and convalescence) and 40 normal controls were tested for CD 62P and CD 63 expression using flow cytometry. The correlation between the expression and neurological functional deficit scale was analyzed.Results (1) The expression of CD 62p and CD 63 in acute phase (9.48%, 8.36%) of ischemic stroke was markedly higher than that in convalescence phase (5.73%, 4.21%)( P0.05). (3) CD 62P and CD 63 expressions were positively related with the scores of neurological functional deficit scale( r=0.84 and r=0.817, P

Background and purpose:Neoadjuvant chemotherapy has become a major therapeutic strategy for the treatment of locally advanced breast cancer.Randomized trials comparing this approach to adjuvant chemotherapy have demonstrated that neoadjuvant chemotherapy was as efficacious as adjuvant chemotherapy and allowed for a higher rate of breast conservation.This study was to evaluate the efficacy and toxicity of docetaxel plus capecitabine in the neoadjuvant chemotherapy of locally advanced breast cancer(LABC) .Methods:Fifty-two patients with LABC were treated with docetaxel 75 mg/m2,d1;Capecitabine 2 000 mg/m2,d1-14.The chemotherapy was repeated every 3 weeks.Effi cacy and toxicities were reviewed after 3 to 4 cycles of chemotherapy.Results:The CR+PR rate was 80.7%.A pathological complete response in the breast was achieved in 5.8% of patients after 4 cycles of docetaxel/capecitabine.The adverse reactions were neutropenia,alopecia and hand-foot syndrome.Conclusion:The combination of docetaxel and capecitabine was well tolerated and effective in LABC for neoadjuvant chemotherapy.

Objective To observe the effect of transperineal injection of botulin A toxin on patients with detrusor-external sphincter dyssynergia caused by spinal cord injury. Methods Transperineal injection of botulin A toxin were performed in 6 patients with spinal cord injury (3 with cervical spinal cord injury and 3 with thoraco-lumbar spinal cord injury) complicated by detrusor-external sphincter dyssynergia.55 U of botulin A toxin was injected twice separately. The interval between 2 injections was 3 days.Before treatment, the residual volume of urine after voiding was determined and the maximum urethral pressure was measured by urodynamic testing.One month after treatment the examination mentioned above was repeated. Results The decrease in residual volume of urine was (133.3?70.9)ml.The decrease in maximum urethral pressure was (35.4?25.8)cmH 2O(both P

Hypothermia has been considered to be detrimental to myocardial protection. In order to evaluate warm blood cardioplegia effects, following CPB, 12 adult mongrel dogs were randomly allocated to be continuously perfused through aortic root with oxygenated warm blood cardioplegia (37 C) (group W, n=6)or cold blood cardioplegia (4C)(group C,n=6)indivadually. The coronary blood samples were taken before coronary perfusion(CP), 60mins and 90mins following CP,to measure the serum activities of lactate dehydrogenase (LDH),creatine phosphokinase (CPK)and glutamic-oxaloacetic transaminase (GOT)and the level of malondialdehyde (MDA). As compared with those before CP,the activities of LDH and CPK increased significantly only at 90th min following CP in group W,and at 60th and 90th min during CP in group C(P0.05) but went up markedly in group C following CP(P0.05) but rose dramatically in group C (P

OBJECTIVE: To study the endosomatic pharmacokinetics and bioequiavailability of kushenin tablets in health adults. METHODS: The blood concentrations of the blood samples taken from 22 healthy volunteers were determined by HPLC-MS after a single oral 0.3g kushenin (either tablet or capsule) dose and pretreatment with the internal standard (cimetidine) with m/z 265 (kushenin) taken as the detection ions and m/z 253 as the internal standard. RESULTS: The main pharmacokinetic parameters of the tablet and capsule of kushenin were as follows: t1/2 stood at (2.30?1.09)h and (1.90?0.58) h, respectively; tmax stood at (1.86?0.74)h and (1.68?0.55) h, respectively; Cmax stood at (525.09?208.94)ng/ml and (530.32?202.04) ng/ml, respectively; AUC0～11 stood at(2 048.5?749.4)(ng?h)/ml and (2 042.0?743.0)(ng?h)/ml, respectively;AUC0～∞ stood at(2 163.2?783.1)(ng?h)/ml and (2 136.4?792.1)(ng?h)/ml, respectively. The relative bioavailability of the kushenin tablet stood at (101.06?9.41) %. CONCLUSION:The tablet and capsule of kushenin were bioequiva_lent.