Objective To explore the clinical effect of mifepristone combined with misoprostol for termina-tion of pregnancy in high risk pregnant women and provide reference for clinical treatment.Methods 182 cases of high -risk maternal were divided into observation group and control group by the random number table method,each group 91 cases.The control group was treated with conventional abortion termination of pregnancy,the observation group was treated with the artificial abortion before oral administration of mifepristone tablets and misoprostol tablets. The operation time,the amount of blood loss,the degree of pain,the degree of cervical softening and the occurrence of complications of induced abortion were compared between the two groups.Results The operation time of the observa-tion group was (2.21 ±1.41)min,intraoperative bleeding was (15.29 ±4.06)mL,which were significantly less than those of the control group (t =7.122,8.256,all P <0.05);The pain degree grade I in the observation group was 58.24%,which was significantly higher than that in the control group,grade III accounted for 5.49%,which was sig-nificantly lower than the that in the control group (χ2 =44.887,44.121,all P <0.05),the observation group of cer-vical softening full was 59 cases,full softening rate was 64.84% and the control group in the cervical softening full was 41 cases,softening full rate was 45.05%.Fully softening rate in the observation group was significantly higher than that in the control group (χ2 =7.191,8.411,P <0.05),the control group,the incidence of uterine perforation in 2 cases,the occurrence of artificial abortion syndrome 7 cases,the incidence of complications for 9.89%,the obser-vation group had no uterine perforation occurred,1 case of artificial abortion syndrome and complications occurred rate was 1.10%.The incidence of complications in the observation group was significantly lower than that in the control group (χ2 =6.772,P <0.05).Conclusion Mifepristone combined with misoprostol for high -risk maternal termi-nation of pregnancy could significantly shorten the artificial abortion operation time,reduce intraoperative blood loss, reduce the patient pain,reduce the incidence of complications.

Objective To discuss the clinical application of preoperative transcatheter arterial chemoembolization (TACE) in treating squamous cell carcinoma of tongue. Methods A total of 26 patients with pathologically proved squamous cell carcinoma of tongue were enrolled in this study. Using Seldinger technique, lingual artery angiography and TACE were carried out in all patients. Radical resection of tongue cancer was performed in 2-3 weeks after TACE. Results Super-selective catheterization and TACE was successfully accomplished in all patients. After TACE the tumor size was significantly decreased in all patients. During the operation, clear lesion's border was observed, and the amount of blood loss was less than usual. Conclusion For the treatment of squamous cell carcinoma of tongue, preoperative superselective TACE is safe and effective;it can increase the opportunity of surgical resection, reduce the surgical damage, and improve the quality of life as well as the survival rate.

The changes in the total and differential leukocyte counts as well as glycogen con- tent and alkaline phosphatase activity of neutrophile granulocyte of peripheral blood were studied during tubal ligation through abdomen with electro-acupuncture at Zha- guan point(tubal ligation point).This work may help to detect the role of the leuko- cytes in the regulatory function of the body and its relationship to acupuncture anal- gesia.The resuhs were as follows: 50 patients undergoing tubal ligation under acupuncture anesthesia were observed. During the operation,the total number of leukocytes was increased as compared with that before the operation.In patients of grade Ⅰefficacy(35 cases)the total number of leukocytes was increased most markedly.In all patients operated under acupuncture anesthesia,the relative proportion of various types of leukocytes showed little or no significant changes,but their absolute number increased to some extent,with the excep- tion of eosinophile granulocyte of grade Ⅱpatients which decreased slightly.A cyto- chemical study of the glycogen content of neutrophil was carried out in 45 patients during acupuncture anaesthesia.The content was decreased during operation especially in 31 cases of Grade Ⅰpatients it was decreased most markedly.On the other hand,the neutro- phil alkaline phosphatase activity was increased during the operation in 20 patients. The control group of 33 cases was further divided into three subgroups.In the first subgroup,we used acupuncture anaesthesia without operation and the total number of leukocytes was decreased slightly.In the second subgroup the patients were operated under local anesthesia(2% procain solution injection subcutaneously),and the last sub- group comprised only normal adults without any operation or anesthesia.There were little or no significant changes in total and differential leukocyte counts during the experiment in th last two subgroups. The above alterations of leukocyte observed in patients operated under acupuncture anesthesia may explain the enhancement of bodily protection produced by acupuncture, by the way of the regulation effect of central nervous system.

Objective To study the changes and clinical significance of P selectin (CD 62P), lysosome protein (CD 63) expression in patients with ischemic stroke.Methods 168 cases of acute ischemic stroke (both acute and convalescence) and 40 normal controls were tested for CD 62P and CD 63 expression using flow cytometry. The correlation between the expression and neurological functional deficit scale was analyzed.Results (1) The expression of CD 62p and CD 63 in acute phase (9.48%, 8.36%) of ischemic stroke was markedly higher than that in convalescence phase (5.73%, 4.21%)( P0.05). (3) CD 62P and CD 63 expressions were positively related with the scores of neurological functional deficit scale( r=0.84 and r=0.817, P

Botulinum neurotoxin(BoNT) is the most lethal biotoxin known to mankind. It inhibits acetylcholinerelease from the cholinergic nerve ending by cleavage of SNARE proteins, followed by neuromuscular blockadeand paralysis. Gangliosides are considered to act as a first receptor of BoNT with low affinity.Then the membranebound gangliosides-BoNT complex moves laterally to reach and bind the toxin specific protein receptor,synaptotagmin, with a high affinity constant. At last the gangliosides-BoNT-synaptotagmin complex undergoesreceptor-mediated endocytosis. This double-receptors theory is widely accepted. The research data are summarizedand reviewed.

The precise surgical treatment for hepatobiliary diseases has been a challenging topic in hepatobiliary surgery for a long time.A perfect preoperative plan can help the surgeon make R0 resection of the lesion and preserve the healthy tissue as much as possible.In addition,all of these depend on the application of different imaging modalities,especially three-dimensional reconstruction technique.But some limitations of 3D reconstruction should be noted:different surgeons may have different views for one object because of different observation points;or it cannot be used for intraoperative re-orientation and so on.3D printed model can overcome some disadvantages of 3D reconstruction.This paper reviewed related literature that reported the usage of 3D printed model in hepatobiliary surgery.

Objective To observe the effect of transperineal injection of botulin A toxin on patients with detrusor-external sphincter dyssynergia caused by spinal cord injury. Methods Transperineal injection of botulin A toxin were performed in 6 patients with spinal cord injury (3 with cervical spinal cord injury and 3 with thoraco-lumbar spinal cord injury) complicated by detrusor-external sphincter dyssynergia.55 U of botulin A toxin was injected twice separately. The interval between 2 injections was 3 days.Before treatment, the residual volume of urine after voiding was determined and the maximum urethral pressure was measured by urodynamic testing.One month after treatment the examination mentioned above was repeated. Results The decrease in residual volume of urine was (133.3?70.9)ml.The decrease in maximum urethral pressure was (35.4?25.8)cmH 2O(both P

Background and purpose:Neoadjuvant chemotherapy has become a major therapeutic strategy for the treatment of locally advanced breast cancer.Randomized trials comparing this approach to adjuvant chemotherapy have demonstrated that neoadjuvant chemotherapy was as efficacious as adjuvant chemotherapy and allowed for a higher rate of breast conservation.This study was to evaluate the efficacy and toxicity of docetaxel plus capecitabine in the neoadjuvant chemotherapy of locally advanced breast cancer(LABC) .Methods:Fifty-two patients with LABC were treated with docetaxel 75 mg/m2,d1;Capecitabine 2 000 mg/m2,d1-14.The chemotherapy was repeated every 3 weeks.Effi cacy and toxicities were reviewed after 3 to 4 cycles of chemotherapy.Results:The CR+PR rate was 80.7%.A pathological complete response in the breast was achieved in 5.8% of patients after 4 cycles of docetaxel/capecitabine.The adverse reactions were neutropenia,alopecia and hand-foot syndrome.Conclusion:The combination of docetaxel and capecitabine was well tolerated and effective in LABC for neoadjuvant chemotherapy.

Hypothermia has been considered to be detrimental to myocardial protection. In order to evaluate warm blood cardioplegia effects, following CPB, 12 adult mongrel dogs were randomly allocated to be continuously perfused through aortic root with oxygenated warm blood cardioplegia (37 C) (group W, n=6)or cold blood cardioplegia (4C)(group C,n=6)indivadually. The coronary blood samples were taken before coronary perfusion(CP), 60mins and 90mins following CP,to measure the serum activities of lactate dehydrogenase (LDH),creatine phosphokinase (CPK)and glutamic-oxaloacetic transaminase (GOT)and the level of malondialdehyde (MDA). As compared with those before CP,the activities of LDH and CPK increased significantly only at 90th min following CP in group W,and at 60th and 90th min during CP in group C(P0.05) but went up markedly in group C following CP(P0.05) but rose dramatically in group C (P