2.Hypoxia increases IRAK-4 expression in cultured murine N9 microglia cells
Journal of Third Military Medical University 2002;0(12):-
Objective To explore the mechanism of the microglia inflammatory response through observing the changes of interleukin-1 receptor associated kinase-4(IRAK-4) expression in murine N9 microglia cells under hypoxia.Methods N9 cells were exposed to 3%O2,5%CO2,92%N2 for 1,3,6,12 and 24 h respectively.The IRAK-4 protein level was detected by Western blotting and the celluar change was observed by laser scanning confocal microscope(LSCM).The TNF-? level was measured by ELISA.Results After hypoxia,the expression of IRAK-4 protein was increased in a time-dependent manner.The elevation began at 1 h after hypoxia,increased significantly at 3 h(P0.05).The fluorescence intensity of IRAK-4 also increased with the extension of anoxic time.The TNF-? level change were similar.There were significant positive correlations between the expression of IRAK-4 and TNF-?(P
3.Gene Therapy of Spinal Cord Injury
Progress in Biochemistry and Biophysics 2001;28(1):29-32
Gene therapy of spinal cord injury (SCI) is the most promising method compared with the others, because it doesn't involve the problems of resource and higher exclusion which respectively exists in fetal nerve transplantation and peripheral nerve transplantation. There are two ways of gene therapy to be chosen: one is to transfer objective genes to the target-cells in vivo directly; the other is to transfer objective genes to one proper kind of transplantable cells firstly, then graft the highest expressing cells to the target-cells in vivo. To realize the transfer of genes to cells, two measures are used in common: physical or chemical measure such as micro infection et al and biochemical measure i. e. gene modified defective virus. Although there are some questions unresolved in this field, the clinical value of gene therapy of SCI in the future is depended.
4.Clinical efficacy of peppermint oil capsules combined with Domperidone in the treatment of bile reflux gastri-tis after gastric surgery
Chinese Journal of Primary Medicine and Pharmacy 2015;(8):1220-1222
Objective To observe the clinical efficacy of peppermint oil capsules combined with domperi-done in the treatment of bile reflux gastritis(BRG)after gastric surgery.Methods Totally 47 patients with BRG after gastric surgery were treated with peppermint oil capsule (0.9g,tid)and domperidone(10mg,tid).Each patient's gas-troscopic manifestations and histopathology were rechecked after 4 weeks.The efficacy was observed on the improve-ment of symptoms and gastric mucosal injury,and on the reduction of bile reflux.Results 42 patients attained satis-factory therapeutic effect with the total efficiency rate of 89.4%.No adverse effects during the treatment period. Conclusion Peppermint oil capsules combined with domperidone shows better efficacy in treatment of BRG after gastric surgery.
5.Yigong powder with Yupingfeng powder for syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia
International Journal of Traditional Chinese Medicine 2015;(6):498-501
ObjectiveTo evaluate the clinical efficacy ofYigongpowder withYupingfengpowder for syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia.MethodsA total of 60 patients who had spleen deficiency after azithromycin injection 5 days were randomly divided into treatment group and control group according to the random number table, with 30 in each group. The patients in both received azithromycin suspension for 2 weeks, while the patients in the treatment group received azithromycin suspension and traditional Chinese medicineYigongpowder withYupingfengpowder for 2 weeks. The symptoms score was used to evaluate the clinical efficacy.ResultsThe scores of appetite loss (0.65 ± 1.00vs. 2.32 ± 1.28,t=5.631), abdominal distention (0.73 ± 0.23vs.1.33 ± 0.97,t=3.297) and fatigue (0.72 ± 0.32vs. 1.42 ± 1.18,t=3.136) in the treatment group were significantly lower than those in the control group (all P<0.05). The total effective rate for syndrome of spleen deficiency in the treatment group was significantly higher than thatin the control group(90.0%vs.66.7%;χ2=4.812,P<0.05).ConclusionYigongpowder withYupingfeng powder can significantly improve the symptoms of syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia.
6.Pregnancy in renal transplant recipient: A case report and review
Journal of Peking University(Health Sciences) 2009;41(6):710-711
SUMMARY In recent years, successful pregnancies in renal transplant women have been reported worldwide. However, pregnancy in renal trasplant recipient is relatively rare in China. This paper reported a case of pregnancy 2 years post renal transplant. At the end of 28 weeks' gestation she had abnormal liver and renal function complicated with severe preeclampsia. Literatures were reviewed on considerations about pregnancy in renal transplant women. Maternal and neonatal outcomes can be improved by intensive care during pregnancy, proper immunosupression and timely termination of pregnancy.
7.Correlation study between urinary calculi and upper urinary tract infections
Chinese Journal of Postgraduates of Medicine 2013;(11):6-8
Objective To investigate the correlation between urinary calculi and upper urinary tract infections.Methods Twenty-six patients underwent lithiasis in upper urinary tract accompanied with infectious symptoms were enrolled in this study (test group).Blood culture was obtained in peak temperature before lithotrity,urine sample was obtained for bacterial culture.Thirty patients with calculi in upper urinary react accompanied no infectious symptoms in the same period were enrolled in control group.Calculi were pestled for bacterial culture and analyzed the components after the calculi were removed.Results In test group,the positive of blood,urine,calculi culture were 4,23,18 patients.The prominent component of calculi was hexahydrate magnesium ammonium phosphate.Bacteria in 13 positive urine sample had the same property with the calculi samples which came from the same cases.In control group,the positive of urine,calculi culture were 4,4 patients.The prominent component of calculi were calcium oxalate calculi and uricite calculi.The morbidity of upper urinary tract infections in test group was significantly higher than that in control group [69.2%(18/26) vs.13.3%(4/30)] (P < 0.05).The coincidence of urine culture and calculi culture in test group was significantly higher than that in control group [72.2%(13/18) vs.25.0%(1/4)](P<0.05).Conclusions Infectious calculi can easily result in upper urinary tract infections.Hexahydrate magnesium ammonium phosphate can make the prominent component in infectious calculi.
8.Pregnancy in renal transplant recipient:A case report and review
Journal of Peking University(Health Sciences) 2003;0(06):-
In recent years,successful pregnancies in renal transplant women have been reported worldwide.However,pregnancy in renal trasplant recipient is relatively rare in China.This paper reported a case of pregnancy 2 years post renal transplant.At the end of 28 weeks' gestation she had abnormal liver and renal function complicated with severe preeclampsia.Literatures were reviewed on considerations about pregnancy in renal transplant women.Maternal and neonatal outcomes can be improved by intensive care during pregnancy,proper immunosupression and timely termination of pregnancy.Abstract:SUMM ARY In recent years,successful pregnancies in renal transplantwomen have been reported world-wide.However,pregnancy in renal trasplant recipient is relatively rare in China.This paper reported a case of pregnancy 2 years post renal transplant.At the end of 28 weeks’gestation she had abnormal liver and renal function complicated with severe preeclampsia.Literatures were reviewed on considerations about pregnancy in renal transplantwomen.Maternal and neonatal outcomes can be improved by inten-sive care during pregnancy,proper immunosupression and timely term ination of pregnancy.
9.Quality Investigation of Prepared Pieces of Root of Stephania Tetrandra S.
Chinese Traditional Patent Medicine 1992;0(02):-
To investigate the quality of prepared pieces of Stephania tetrandra S.the content of total alkaloids and tetrandrine of the products prepared by 10 different prepared pieces of Chinese medicine factories has been determined. In conclusion, it is practicable to prescribe the content of total alkaloids and tetrandrine for 3% and 1%, respectively.
10.Antibacterial effect of ceftriaxone combined with rifampicin in the treatment of children with purulent meningitis
Chinese Journal of Primary Medicine and Pharmacy 2017;24(14):2191-2194
Objective To explore the effect of ceftriaxone combined with rifampicin in the treatment of children with purulent meningitis,thus to provide reference for related studies.Methods 120 children with purulent meningitis were selected and randomly divided into observation group(67 cases) and control group (53 cases) according to the digital table.The control group received treatment of ceftriaxone,and the observation group received ceftriaxone and rifampicin.The clinical effect,recovery time of clinical indicators,total protein (TP),C-reactive protein (CRP),and serum protein C level were observed in the two groups.Results After treatment,the total effective rate of the observation group was 97.01%,which was higher than 86.79% of the control group,the difference was statistically significant(x2=4.457,P<0.05).The recovery time of body temperature,peripheral leukocyte count,and CSF leukocyte in the observation group were (2.35±0.68)d,(5.27±1.56)d,(13.27±1.71)d,respectively,which in the control group were shorter than (3.36±0.36)d,(7.24±2.09)d,(16.74±2.66)d,respectively,the differences were statistically significant(t=-9.713,-5.926,-8.643,all P<0.05).After treatment,the TP and CRP decreased in two groups,serum protein C was increased,and the above indicators of the observation group improved more significantly,there were statistically significant differences(all P<0.05).There was no significant differences in the incidence of complications between the two groups(P>0.05).Conclusion Ceftriaxone combined with rifampicin in the treatment of children with purulent meningitis can reduce inflammation and promote the recovery time of clinical indicators,and it's worthy of reference.