Objective Propofol has profound influence on respiration. The purpose of this study was to evaluate the effect of propofol on respiratory mechanics during painless induced abortion. Methods Forty ASA Ⅰ women in early pregnancy (45-60 days) aged 17-52 yrs, weighing 42-80 kg undergoing induced abortion were enrolled in this study. Anesthesia was induced with intravenous 2.5 mg?kg-1 and maintained with intermittent i.v. boluses of propofol 30-50 mg. SpO2 and HR were monitored with Nellcor N-180 pulse oximeter. Respiratory mechanics was monitored with IFA-300 anemometer (TSI Co. USA) . The parameters measured included inspiratory / expiratory maximal air-flow velocity, inspiratory / expiratory mean air flow velocity, mean inspiratory and expiratory time, respiratory rate, inspiratory / expiratory air flow volume, dynamic inspiratory and expiraory airway pressure and indidence of apnea.Results SpO2 decreased significantly during maintenance of anesthesia with propofol. The mean and maximal inspiratory / expiratory airflow velocity and the inspiratory / expiratory airflow volume all decreased significantly during propofol anesthesia. The dynamic inspiratory / expiratory airway pressure significantly decreased during propofol anesthesia. The respiratory rate was significantly higher during propofol anesthesia while the mean inspiratory /expiratory time became shorter. Three patients developed apnea during induction of anesthesia with propofol (7.5%) . Spontaneous breathing returned within 1 min. Conclusion Spontaneous breathing is significantly depressed during propofol anesthesia in terms of respiratory mechanics. Care should be taken to maintain oxygenation and ventilation of the patient.

Seventy-six cases of Asherman's syndrome (traumatic amenorrhea) were analyzed clinically. 70% of the patients were young women of the ages from 20 to 30. There was the history of previous abortion with once or twice of curettage in 81.2% of the cases. 66 out of the 76 cases complained of amenorrhea, 57 of periodic lower abdominal pain, and 10 of hypomenorrhea.When the intrauterine adhesions are explored, diagnostic curettage to get some endometrium for histologic study should be done since it is essential to diagnosis as well as to treatment. 57 out of the 76 were cured with one procedure of probe isolation of the adhesions and dilatation. The remained 19 cases were treated with combined Chinese traditional and Western medicine and 15 were cured and 4 improved. 24 women of those cured underwent a normal full term pregnancy and gave birth to a normal child. No vaginal bleeding or adhesion of placenta was observed after delivery in those women.

This paper adopted UG8.0 to bulid the stent and blood vessel models. The models were then imported into the finite element analysis software ANSYS. The simulation results of ANSYS software showed that after endothelial stent implantation, the velocity of the blood was slow and the fluctuation of velocity was small, which meant the flow was relatively stable. When blood flowed through the endothelial stent, the pressure gradually became smaller, and the range of the pressure was not wide. The endothelial shear stress basically unchanged. In general, it can be concluded that the endothelial stents have little impact on the flow of blood and can fully realize its function.
Computer Simulation ; Finite Element Analysis ; Humans ; Models, Cardiovascular ; Software ; Stents ; Stress, Mechanical

Chlamydia pneumoniae is one of the most common pathogens causing community acquired pneumonia.It may activate immune cells,release mediators of inflammation and cytokine and cause immune response.Researches on its signal transduction after infection through Toll-like receptors may help prevent and cure chlamydia penumoniae infection disease.

From 1952 to 1990, 21 cases of malignant tumor of the appendix, including 14 cases of carcinoid tumor of appendix, 4 cases of appendix adenocarcinoma, 2 cases of appendix lymposarcoma and 1 case of appendix cystocarcinoma, were treated in the Affiliated Hospital of Wannan Medical College Among these 21 patients, 16 underwent appendectomy alone, 5 underwent appendectomy first and a right hemicolectomy was performed on later All of the 21 patients were followed up for 5～10 years,the survival rate was 90 5% and 90 5% respectively So if a malignant tumor of the appendix was suspected, a biopsy during operation should be done to determine the pathological type If the diagnosis was clear, the choice of operation mode must be made according to the size and the pathological type of the tumor In selective patient, a right hemicolectomy must be performed on

OBJECTIVE The roles of sense neuropeptides in the allergic rhinitis were investigated by observing the symptoms and changes in the level of the neuropeptides in rabbits sensitized after severing of their sphenoidpalatine or sympathetic nerve. METHODS ①SP and CGRP were observed in nasal mucosa of rabbits in four weeks. ② Twenty rabbits were divided into three groups: group C(sphenoidpalatine nerve severed),group D(sympathetic nerve severed) and group E(not operated on).Groups C and D were sensitized three days after the operation. Four rabbits were killed at two and four weeks post-operation in groups C and D. RESULTS ①There was no difference between SP and CGRP levels in four weeks. ②The levels of SP in the nasal mucosa of group C at two and four weeks after sensitization were 16.1?0.77 and 15.02?0.24, respectively. The levels of SP in group D were 34.13?1.45 and 33.23?1.99, respectively. The levels of SP in group E were 20.68?0.01 and 20.56?1.27, respectively. The level of SP in Group C was lower than in Group E. The level of SP in Group D was higher than in Group E. The level of CGRP correlates with the level of SP. CONCLUSION SP and CGRP levels are correlated with the occurrence and development of allergic rhinitis.

Objective To investigate the effect of TLCK(N-alpha-tosyl-L-lysyl-chloromethylketone) on acute hemorrhagic necrotizing pancreatitis(AHNP) associated with lung injury.Methods Seventy SD rats were randomized into seven groups(n=10 in each group): group1,normal control group(rats were treated with 0.9% sodium chloride i.v.);group 2,AHNP control group(AHNP rats were treated with 0.9% sodium chloride i.v.);group 3,AHNP rats were treated with 5?g/kg TLCK;group 4,AHNP rats were treated with 10?g/kg TLCK;group5,AHNP rats were treated with 20 ?g/kg TLCK;Group3,4,5were treated with TLCK i.v.immediately after the establishment of SAP rat model;group 6,AHNP rats were treated with TLCK i.v.30 minutes before the establishment of AHNP model;group 7,AHNP rats were treated with TLCK i.v.30 minutes after the establishment of AHNP rat model;Group 6,7 were treated with 10 ?g/kg TLCK.Group 1-7 were used to select the best dosage and administration time of TLCK by observing the survival rate for seven days.Then,according to the result of selecting,the SD rats were divided into three groups(n=6 in each group): group N,Sham operated control group(0.9% sodium chloride was reversely injected into SD rat′s pancreas and rats were treated with 0.9% sodium chloride i.v.);group P: AHNP group;group T: TLCK treatment group(AHNP rats were treated with 10 ?g/kg TLCK immediately after the establishment of AHNP rat model).The rats of the last three groups were killed 6 hours after operation.Alveolar macrophages(AMs) were harvested by bronchoalveolar lavage.The protein content of bronchoalveolar lavage fluids(BALF),the myeloperoxidase(MPO) of lung tissue,and tumor necrosis factor ?(TNF?) secreted by AMs were determined.The expression of NF-?B in AM was checked as well as lung histology.Results The survival rate of group 1-7 was100%,0%,70%,100%,80%,0%,and 90% respectively.The level of MPO of lung tissue and protein content of BALF ingroup N were lower than that,in groups P and T(P

Objective:To explore the clinical efficacy, especially the comprehensive improvement of blood glucose and lipid of probucol and metformin in the treatment of type 2 diabetes mellitus with hyperlipidemia. Methods:Totally 105 patients with type 2 di-abetes mellitus complicated with hyperlipidemia were randomly divided into the control group1 (35 cases), the control group 2 (34 ca-ses) and the observation group (36 cases). The control group 1 was treated with diet control, exercise and metformin, the control group 2 was treated with rosuvastatin calclum tablets based on the group 1, and the observation group was treated with probucol based on the group 1. The three groups were continuously treated for 12 weeks. The improvement of the fasting blood-glucose (FPG), 2h postprandial blood glucose (PBG), hemoglobin A1C (HbA1C), fasting insulin levels (Fins), insulin resistance indices (HOMA-IR) and TC, TG and HDL-C, and the adverse reactions among the three groups were compared. Results:The total effective rate in the ob-servation group was higher than that in the control group 1 and 2 (P<0. 05). After the treatment, all the indices of blood glucose and lipid in the three groups were significantly improved (P<0. 05), and those of blood glucose in the observation were better than those in the control group 1 and 2(P<0. 05), those of blood lipid in the observation group and the control group 2 were better than those in the control group 1 (P<0. 05), and the level of HDL-C in the observation group was much higher than that in the control group 2 (P<0. 05). The adverse drug reactions in the three groups were mild without statistical significance (P>0. 05). Conclusion:Probucol as one of lipid-lowing drugs with antioxidant action combined with metformin can improve blood lipid and lower blood glucose at the same time, which is worthy of promoted application in clinics.

Sulfogalactosylglycerolipid (SGG) is the main glycolipid in male mammalian germ cells, which is selectively and highly expressed in mammalian testes and helps form the lipid bilayer of cell membrane. In the process of spermatogenesis, SGG is involved in the meiosis of spermiocytes. Either deficiency or accumulation of SGG will lead to male infertility. SGG homeostasis in the testis is the premise of normal spermatogenesis. In the process of sperm-zona binding, SGG becomes a component of lipid raft and provides a platform for signal transduction. The SGG binding protein plays a role in sperm-egg recognition and membrane fusion. SGG has a great research value and application prospect in male reproduction.
Animals ; Cell Membrane ; Galactolipids ; physiology ; Humans ; Infertility, Male ; etiology ; Lipid Bilayers ; metabolism ; Male ; Signal Transduction ; Sperm-Ovum Interactions ; physiology ; Spermatogenesis ; physiology ; Spermatozoa ; metabolism ; Testis ; physiology

Objective To study the effect of ulinastatin on serum C-reactive protein (CRP) and exhaled nitric oxide(FeNO) in patients with bronchial asthma.Methods 98 patients with bronchial asthma were randomly divided into the control group (n =49 cases) and the observation group (n =49 cases).The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated through the conventional treatment plus ulinastatin.Pulmonary function,asthma symptom scores,serum CRP and FeNO were measured before and after treatment.Results FEV1％ and predicted PEF values after treatment were significantly increased (t =4.720,8.112,3.724,6.723,all P ＜ 0.05).Compared with the control group,the observation group after treatment increased more significantly (t =3.102,4.002,all P ＜ 0.05).After the treatment,the asthma symptom scores were significantly decreased (t =2.190,6.021,all P ＜ 0.05).Compared with the control group,the asthma symptom scores of the observation group significantly decreased (t =2.620,P ＜ 0.05).After treatment,FeNO and CRP were significantly decreased (t =9.124,13.076,5.772,7.064,all P ＜ 0.01).Compared with the control group,FeNO and CRP of the observation group significantly decreased (t =3.060,5.401,all P ＜ 0.05).Conclusion Ulinastatin can significantly decrease serum CRP and FeNO in patients with bronchial asthma.