Objective To investigate the treatment of threatened abortion progesterone maternal serum pro-gesterone -induced blocking factor (PIBF)levels and clinical significance,in order to be able to provide theoretical references of progesterone treatment of threatened abortion.Methods Threatened abortion women (study group)and non -threatened abortion women (control group),50 patients in the observation group given progesterone therapy, enzyme -linked immunosorbent assay (ELISA)was used to detect serum progesterone and PIBF levels of the obser-vation group before treatment and two weeks later,the control group was selected and named after two weeks.Results Observation group after treatment 47 patients progesterone tocolysis successful,success rate was 94.00%,tocolysis bleeding stop time 8.42d,abdominal pain time 11.32d.PIBF of the observation group was (313.52 ±90.43)mmol/L, which was lower than that of the control group (398.47 ±104.25)mmol/L,the difference was statistically significant (t =10.90,P <0.05).The progesterone of the observation group after 2 weeks of treatment was (92.35 ±20.85)mmol/L, which was higher than that before treatment (74.49 ±14.22)mmol/L,compared with progesterone levels of the con-trol group at the same time (83.26 ±20.14)mmol/L and (78.05 ±15.38)mmol/L,the difference was statistically significant (t =7.96,8.11,P <0.05),PIBF after 2 weeks of treatment in the observation group was (510.73 ± 87.49)mmol/L,which was higher than that of the control group at the same time (498.26 ±69.88)mmol/L,the difference was statistically significant (t =4.35,P <0.05).Follow -up observation group miscarriage successful term delivery rate 95.74% of pregnant women,childbirth fetal malformations seen in the control group of pregnant women at term birth rate was 94.00%,no delivery fetal malformation,the difference of full -term delivery rate was not statis-tically significant (P >0.05).Conclusion Reduced PIBF during early pregnancy may be one of the reasons of threatened abortion,the use of progesterone therapy can increase PIBF expression,possibly through this pathway plays a role in tocolysis,so when using progesterone tocolysis monitoring PIBF levels helps evaluate the efficacy of tocolysis.

High-dose therapy (HDT) combined with autologous hematopoietic stem cell transplantation (AHSCT) is a standard treatment for relapsed or refractory aggressive lymphoma. However, the role of HDT/AHSCT in the first-line treatment of lymphoma remains controversial, and related issues about its application in different subtypes of lymphoma should be addressed. This article brief-ly reviewed the clinical progress in AHSCT for malignant lymphoma treatment.

AIM:To investigate the effect of microRNA-16 ( miR-16) on the proliferation, invasion and cyto-kine secretion of rheumatoid arthritis ( RA) synovial fibroblasts ( RASFs) from the RA patients.METHODS: miR-16 mimic and miR-16 inhibitor were synthesized, and then Transfected into RASFs isolated from RA patients with lipo-fectamine.MTT assay, Transwell chamber and flow cytometry were used to determine the effect of miR-16 on proliferation, invasion and apoptosis of RASFs.The expression of matrix metalloproteinase 3/13 ( MMP3/13) and interleukin 1β( IL-1β) was measured by RT-PCR and Western blotting.RESULTS: The proliferation and invasion of RASFs were signifi-cantly inhibited by miR-16 mimic.The result of flow cytometry demonstrated that miR-16 had no effect on apoptosis of RASFs.Furthermore, miR-16 down-regulated the expression of MMP3/13 and IL-1β.CONCLUSION:miR-16 plays an important role in the development of RA and may inhibit the proliferation and invasion of RASFs through down-regulating the expression of MMP3/13 and IL-1β.

This article introduces the basic principles of finite element analysis in biomechanics, focusing on the basic principles of a variety of finite element analysis software, and their respective characteristics. In addition, it also de scribes the basic stress analysis of UGNX6.0 NASTRAN analysis for artificial knee process, i. e. the choice of the type, material definition, the set of constants, finite element mesh division and the finite element results of the analysis. Finite element analysis and evaluation of the design of personalized artificial knee were carried out, so that the rationality of the geometric design of the structure of the experimental design of artificial knee has been verified.
Biomechanical Phenomena ; Bionics ; Finite Element Analysis ; Humans ; Knee Joint ; Knee Prosthesis ; Prosthesis Design ; Stress, Mechanical

Acute Disease ; Humans ; Male ; Middle Aged ; Occupational Diseases ; diagnosis ; therapy ; Phosgene ; poisoning ; Poisoning ; diagnosis ; therapy

Female ; Fertility ; Humans ; Nutritional Status

Child ; Emergencies ; Female ; Humans ; Nutritional Sciences

A new method using the ideal mid-facial line as the navigating reference was introduced to improve the outcome of cleft lip repair. Using the verticle coordinate crossing the middle point of the intercanthus line, surgeons could observe and correct the distortion of the fine structures in labial-nasal area. This laser projecting mid-facial-line navigation was repeatable, while not interfere the operating. In conclusion, generalizing laser navigation is a valuable supplementary for cleft lip repair.
Cleft Lip ; surgery ; Face ; Lasers ; Nose ; Oral Surgical Procedures ; methods ; Surgical Flaps ; Treatment Outcome

Humans ; Skin ; pathology ; Trichloroethylene ; poisoning

Type 2 diabetes mellitus,a endocrine disease,threatens human health.Recent researches have indicated that the osteoprotegerin is associated with type 2 diabetes mellitus closely.The content of osteoprotegerin, existing in circulating system, pancreas, liver and fat of diabetic patients, changed significantly.The osteoprotegerin is also closely related to the vascular complication of diabetes mellitus, which has been discussed by many scholars.In this paper, the relation between osteoprotegerin and type 2 diabetes mellitus is summarized by reviewing relevant literatures, Providing new ideas concerning treatment of diabetes mellitus.