1.Tailgut Cyst with Glomus Coccygeum: Report of a case.
Mi Jung KIM ; Shi Nae LEE ; Sung Sook KIM ; Hea Soo KOO ; Ok Kyung KIM
Korean Journal of Pathology 1996;30(7):643-645
Tailgut cyst of retrorectal space is uncommon and its classification and prognosis are unclear. The lesion usually consists of a multiloculated cyst lined by squamous, transitional, and glandular epithelium. Disorganized fascicles of smooth muscle may be seen in the wall. Glomus coccygeum, normally located at the tip of coccyx, is incidentally discovered in the presacral mass including tailgut cyst. We report a case of tailgut cyst in a 35 year old female who had internal hemorrhoid and intermittent anal pain for 3 years. Pelvic computerized tomography revealed a 3x2 cm sized mass in the presacral area. The mass was multicystic and lined by squamous, transitional, and peudostratified ciliated columnar epithelium with inflammatory cells and scattered smooth muscle in the wall. Dermal adnexal structures were not present, which excluded dermoid cyst. A glomus body was identified in the surrounding soft tissue.
Female
;
Humans
;
Cysts
2.Effects of Interferon Gamma on Collagen Expression in the Partially Obstructed Urinary Bladder of Rat.
Kyu Sung LEE ; Kwang Myung KIM ; Jung Yun JUNG ; Ahnkie LEE ; Hae Il CHEONG ; Cheol Keun PARK ; Shi Whang KIM
Korean Journal of Urology 1999;40(6):740-748
PURPOSE: Recent studies have proved that bladder compliance is closely related to the collagen content of the bladder. It has been shown through human fibroblast, condrocyte, and rat myofibroblasts that interferon(IFN)-gammadecreased collagen synthesis. The objective of this study was to investigate the alteration of collagen deposition and gene expressions in collagen types I and III by partial bladder outlet obstruction and to compare the changes during IFN-gamma treatment. MATERIALS AND METHODS: Following 4 weeks of partial bladder outlet obstruction in 200-250gm. SD rats, the bladder tissues were evaluated for collagen deposition by an immunohistochemical staining using the polyclonal antibodies and the messenger ribonucleic acid(mRNA) contents of the collagen type I and III were evaluated by Northern hybridization. Recombinant IFN-gamma(100,000 units) was administered once a day for 4 weeks by subcutaneous injection. RESULTS: In the control bladders, the immunohistochemical staining for type I and type III collagen protein showed an intense localization in the lamina propria with modest localization in the inter-fascicular region. With obstruction type I and type III collagen staining intensified, especially in the inter-fascicular region. The IFN-gamma administration reduced the inter-fascicular deposition of collagen type I and III. There was an up-regulation of collagen type I and III gene expression after the obstruction. In the obstructed bladders proalpha1(I) and proalpha1(III) collagen mRNA intensity was increased 3.4 and 5.1 folds than the control groups, respectively. This up-regulation was down-regulated by IFN-gamma administration. CONCLUSIONS: The down regulation of collagen types I and III gene expression, and decreased protein deposition after IFN-gamma treatment demonstrated that the effect of IFN-gamma was, in part, transcriptionally regulated. These results suggest that the recombinant IFN-gamma may be beneficial in the treatment of patients with poorly compliant bladder.
Animals
;
Antibodies
;
Collagen Type I
;
Collagen Type III
;
Collagen*
;
Compliance
;
Down-Regulation
;
Fibroblasts
;
Gene Expression
;
Humans
;
Injections, Subcutaneous
;
Interferon-gamma
;
Interferons*
;
Mucous Membrane
;
Myofibroblasts
;
Rats*
;
RNA, Messenger
;
Up-Regulation
;
Urinary Bladder Neck Obstruction
;
Urinary Bladder*
3.The Value of Increased Nuchal Translucency(NT) for the Prediction of Abnormal Pregnancy Outcome.
Eun Sung KIM ; Ho Won HAN ; Hyun Mee RYU ; Jae Hyuk YANG ; Mun Young KIM ; Shi Jun YOO ; Young Ho LEE ; Jung Ryol HAN ; Kyung Sang LEE
Korean Journal of Perinatology 1998;9(4):363-374
PURPOSE: To evaluate the NT in the first trimester associated with fetal chromosomal abnormality, fetal structural abnormality and adverse pregnancy outcome. METHODS: From Mar. 1993 to Dec. 1997, 133 cases of increased NT were reviewed retrospectively. All these fetues were taken a karyotyping and/or a high resolution ultrasonography for associated anomaly. The NT was measured by transvaginal ultrasonography(TVS) and transabdominal ultrasonography(TAS) if difficulty was encountered with TVS in the period of the 10th-14th week of gestation. The increased NT is approved when it is over 3mm. RESULTS: Of these 133 cases, 102 cases(76.7%) revealed normal outcomes and 31 cases(23.3%) revealed abnormal outcomes such as chromosomal abnormality, structural abnormality and adverse pregnancy outcome, The mean value of NT was 3.44+/-0.68mm in the normal group and 4.93+/-2.70mm in the abnormal group, respectively. The chromosomal abnormalities were found in 16 of the 31 cases: nine Down SD, two Patau syndrome, one Tuner synrome, one triploidy, one 46, XX,i(18q), one 47,iso(Xp)/46,XX one confined placental mosaicism. In 12 cases of the 31 cases, the structural anomalies were detected. Of these 12 cases, 3 cases were eventually developed to cytsic hygroma, 3 cases were cardiac anomaly, 3 cases were renal anomaly, 1 case was congenital diaphragmatic hernia, 1 case was skeletal dysplasia and 1 case was suspected syndrome. The adverse pregnancy outcome such as intrauterine growth restriction, intrauterine fetal death and preterm labor was revealed in 3 cases. In the cases of NT over 7mm, the result was 100% abnormal outcome. CONCLUSION: Increased NT in the first trimester could be a highly efficient the predictor for detection of chromosomal abnormality, structural anomaly and adverse pregnancy outcome.
Chromosome Aberrations
;
Female
;
Fetal Death
;
Hernia, Diaphragmatic
;
Humans
;
Karyotyping
;
Lymphangioma, Cystic
;
Mosaicism
;
Nuchal Translucency Measurement
;
Obstetric Labor, Premature
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy Trimester, First
;
Pregnancy*
;
Retrospective Studies
;
Triploidy
;
Ultrasonography
4.Ebstein's Anomaly: Echocardiographic and Clinical Features in the Fetus.
Jee Yeon MIN ; Shi Joon YOO ; Young Ho LEE ; Eun Sung KIM ; Moon Young KIM ; Hyun Mee RYU ; Eun Jung BAE ; Heung Jae LEE
Korean Circulation Journal 1998;28(3):405-411
BACKGROUND: Ebstein's anomaly is characterized by various degrees of apical displacement of the proximal attachment of the tricuspid valve. The disease has an extremely variable course in presenting itself. Therefore, we examined the morphologic and clinical features of Ebstein's anomaly as presented in the fetus to define the factors that determine its outcome. METHODS: We reviewed the history and echocardiographic studies of 10 fetuses (mean gestational age 28.0 weeks) diagnosed in utero with Ebstein's anomaly. The reason for referral was cardiomegaly on routine obstetric scanning in 5 cases, fetal arrhythmia in 3 cases, small main pulmonary artery in 3 cases, vessel view in 1, and twin pregnancy complicated by polyhydramniosis in 1. RESULTS: Of the 10 cases, pregnancy was terminated after diagnosis in 5, 2 cases were carried to term, and 1 case was at 34 weeks of gestation. We were unable to follow-up 2 cases. There were no intrauterine deaths and no misdiagnoses. Massive cardiomegaly and severe tricuspid regurgitation were detected in 7 cases; mild cases were detected in two, and one was nearly normal. Associated cardiac lesions included pulmonary artresia in 4 cases, pulmonary stenosis in 3, and pulmonary hypoplasia in 1. The cases with right ventricular outflow tract (RVOT) obstruction showed a tendency to develop more cardiomegaly and tricuspid regurgitation than with normal RVOT. There was no abnormality in other organ systems and karyotyping. CONCLUSION: Although increased cardiothoracic ratio and associated lesions of the right ventricular outflow tract contribute to the poor outcome in the prenatally detected cases, the absence of these features does not always indicate a good prognosis because progression of the disease can occur with advancing gestational age. No absolute measurement or single echocardiographic feature emerged as a consistent predictive factor for prognosis.
Arrhythmias, Cardiac
;
Cardiomegaly
;
Diagnosis
;
Diagnostic Errors
;
Ebstein Anomaly*
;
Echocardiography*
;
Fetus*
;
Follow-Up Studies
;
Gestational Age
;
Karyotyping
;
Pregnancy
;
Pregnancy, Twin
;
Prognosis
;
Pulmonary Artery
;
Pulmonary Valve Stenosis
;
Referral and Consultation
;
Tricuspid Valve
;
Tricuspid Valve Insufficiency
5.Two Cases of Metastatic Leiomyosarcoma Diagnosed by Fine Needle Aspiration.
Shi Nae LEE ; Hee Soo YOON ; Sung Sook KIM ; Hae Soo KOO ; Jung Su SEO
Korean Journal of Cytopathology 1996;7(1):107-110
Cytologic finding of 2 cases of metastatic leiomyosarcoma diagnosed by fine needle aspirtion cytology are reported. Case 1 is pleomorphic leiomyosarcoma which had metastsized to the liver from the stomach of a 54-year-old male patient. The cytologic features showed highly cellular aspirates with nuclear pleomorphism and interlacing patern. Case 2 is low grade leiomyowsarcoma that occurred in the uterus of a 43-year female patient and metastsized to both lungs. The aspirates were less cellular than that of case 1, and showed spindle cells with minimal pleomorphism, but cell block revealed interlacing patterns of smooth muscle cells with occasional mitosis.
Biopsy, Fine-Needle*
;
Female
;
Humans
;
Leiomyosarcoma*
;
Liver
;
Lung
;
Male
;
Middle Aged
;
Mitosis
;
Myocytes, Smooth Muscle
;
Needles
;
Neoplasm Metastasis
;
Stomach
;
Uterus
6.Multisystem Inflammatory Syndrome in an Adult after COVID-19 Vaccination: a Case Report and Literature Review
Jung Wan PARK ; Shi Nae YU ; Sung Hae CHANG ; Young Hyeon AHN ; Min Hyok JEON
Journal of Korean Medical Science 2021;36(45):e312-
As the number of people vaccinated increases, people who complain of adverse reactions continue to occur. We experienced a case characterized by low blood pressure, persistent fever, edema due to increased systemic vascular permeability, and systemic inflammation confirmed by image and laboratory examinations after ChAdOx1 coronavirus disease 2019 (COVID-19) vaccination. The diagnostic criteria for multisystem inflammatory syndrome (MIS) in adults are known as fever of 3 days or more in adults, 2 or more mucocutaneous/ gastrointestinaleurologic symptoms, elevation of inflammatory markers, and clinical/ imaging diagnosis of heart failure. A 67-year-old man who was medicated for hypertension and diabetes was admitted complaining of fever, maculopapular rash, diarrhea, headache, chills, and dizziness 6 days after the first vaccination of ChAdOx1 nCoV-19 in Korea.The COVID-19 test was negative but with low blood pressure, leukocytosis, skin rash, pulmonary edema, and increased inflammation markers. His lab findings and clinical course were consistent with those of MIS after COVID-19 vaccination. He was medicated with methylprednisolone 1 mg/kg and diuretics and recovered rapidly. He was discharged after 2 weeks and confirmed cure at outpatient clinic. We report an MIS case after COVID-19 vaccination in Korea.
7.Aortoventriculoplasty with The Pulmonary Autograft: The "Ross-Konno" Procedure: 1 case report.
Woong Han KIM ; Young Thak LEE ; Seob LEE ; Jung Hyeun BANG ; Wook Sung KIM ; Jae Chun SHIM ; Cheol Hyun CHUNG ; Chan Young NA ; Yoon Seop JEONG ; Jae Jin HAN ; Do Hyun JUNG ; Il Sang JUNG ; Jung Won PARK ; Young Kwan PARK ; Sung Nok HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1997;30(4):419-422
In small children with left ventricular outflow tract obstruction, a few methods of surgical treatment could be considrred. The pulmonary autogrart provides a promising options for aortic valve replacement as part of the aortoventriculoplasty procedure in children. We report a successfully treated congenital aortic stcnoinsufricicncy with severe left ventricular dysfunction in an early infant with the aortoventriculoplasty using thc pulmonary autograft (the Ross-Konno procedure).
Aortic Valve
;
Autografts*
;
Child
;
Dronabinol
;
Humans
;
Infant
;
Transplantation, Autologous
;
Ventricular Dysfunction, Left
;
Ventricular Outflow Obstruction
8.A Case of Paradoxical Renal Embolism through Patent Foramen Ovale.
Dae Seop LIM ; Eun Soo JEONG ; Jin Sung JUNG ; Se Heon CHANG ; Seung Hyen YOO ; Woo Jin JANG ; Shi Jung CHUNG
Korean Journal of Nephrology 2011;30(6):667-670
Paradoxical embolism is a kind of stroke caused by embolism of thrombus of venous origin through a lateral opening in the heart, such as a patent foramen ovale (PFO). Although the most frequent manifestation of paradoxical embolism is cryptogenic stroke, noncerebral paradoxical embolism is also associated with PFO. We experienced a case of cryptogenic renal infarction in a previously healthy 70-year-old man. He had no cardiac thrombus on transthoracic echocardiography and electrocardiogram revealed a normal sinus rhythm. Because it was cryptogenic renal infarction, we performed transesophageal echocardiography with microbubble test. Microbubble test using agitated saline proved the presence of right-to-left shunt and patent foramen ovale was diagnosed. We also performed lower leg doppler ultrasonogram, but there was no evidence of deep vein thrombosis. Although only the presence of a right-to-left shunt is not enough to establish the diagnosis of paradoxical embolism, it is uncommon for the source of the embolism to be identified. In this case, we concluded that paradoxical embolism is the cause of renal embolism. We report paradoxical renal embolism through PFO with review of relevant literatures.
Aged
;
Dihydroergotamine
;
Echocardiography
;
Echocardiography, Transesophageal
;
Electrocardiography
;
Embolism
;
Embolism, Paradoxical
;
Foramen Ovale, Patent
;
Heart
;
Humans
;
Infarction
;
Kidney
;
Leg
;
Microbubbles
;
Stroke
;
Thrombosis
;
Venous Thrombosis
9.A Case of Mediastinal Tuberculous Lymphadenitis Mimicking a Submucosal Tumor of the Esophagus.
Se Jin KIM ; Seok Won JUNG ; Sejin HWANG ; Young Arm YI ; Jong Min KIM ; Shi Jung SUNG ; In Du JEONG
Korean Journal of Medicine 2011;80(3):328-332
Esophageal involvement in tuberculosis is rare, and the clinical presentation may mimic an esophageal submucosal tumor. A 30-year-old woman presented with dysphagia for 1 month. At esophagoscopy, a 3-cm subepithelial mass with normal covering mucosa was found 28~25 cm from the upper incisors. We diagnosed the lesion as a submucosal tumor of the esophagus and performed endoscopic ultrasonography 1 week after the first examination. The second endoscopy showed a large, linear ulceration on the same subepithelial mass. The histologic examination obtained following an endoscopic biopsy revealed chronic granulomatous inflammation, and a molecular nested PCR study for Mycobacterium tuberculosis was positive. The final diagnosis was mediastinal tuberculous lymphadenitis with invasion into the esophagus. We suggest the use of molecular biology techniques when there is a strong clinical suspicion of tuberculosis and difficulty in arriving at a definite diagnosis.
Adult
;
Biopsy
;
Deglutition Disorders
;
Endoscopy
;
Endosonography
;
Esophagoscopy
;
Esophagus
;
Female
;
Humans
;
Hydrazines
;
Incisor
;
Inflammation
;
Mediastinum
;
Molecular Biology
;
Mucous Membrane
;
Mycobacterium tuberculosis
;
Polymerase Chain Reaction
;
Tuberculosis
;
Tuberculosis, Lymph Node
;
Ulcer
10.Non-invasive prediction of clinical infection in women with preterm labor.
Sung Youn LEE ; Kyo Hoon PARK ; Kyung Joon OH ; Eun Ha JEONG ; Shi Nae KIM ; Hee Jung JUNG
Korean Journal of Obstetrics and Gynecology 2010;53(11):973-980
OBJECTIVE: To develop a model based on non-invasive variables to predict the probability of subsequent maternal and/or neonatal clinical infection in women admitted to hospital for preterm labor with intact membranes. METHODS: Transvaginal ultrasound for measurement of cervical length was performed and maternal blood was collected for the determination of white blood cell (WBC) count at admission in 165 consecutive women with preterm labor (between 20.0 and 35.0 weeks). Clinical infection was defined as the presence of clinical chorioamnionitis at delivery or early onset neonatal sepsis. Receiver operating characteristic (ROC) curves and logistic regression analysis were used for statistical analyses. RESULTS: The prevalence of clinical infection was 5% (8/165). Women who developed clinical infection had a significantly lower median gestational age at admission, a lower shorter median cervical length, and a higher median WBC count as compared to those who did not develop clinical infection. Logistic regression analysis was performed and a final model was chosen, which included maternal blood WBC, cervical length, and gestational age as the best predictors of clinical infection. A risk score was calculated containing these 3 variables for each patient. The model was shown to have an adequate goodness of fit (P=0.202), and the area under the ROC curve was 0.822, indicating reasonably good discrimination. CONCLUSION: In women admitted to hospital for preterm labor with intact membranes, the risk for the subsequent maternal and/or neonatal clinical infection can be predicted non-invasively with a risk score based on cervical length at admission, maternal blood WBC, and gestational age.
Chorioamnionitis
;
Discrimination (Psychology)
;
Female
;
Gestational Age
;
Humans
;
Leukocytes
;
Logistic Models
;
Membranes
;
Obstetric Labor, Premature
;
Pregnancy
;
Prevalence
;
ROC Curve
;
Sepsis