No abstract available.
Hand*

Clinical observations and histopathologic behaviors of testicular tumors were made on 39 cases who were admitted to the Department of Urology, Seoul National University Hospital, during the period from January, 1966 to December, 1979. The results are summarized as follows; 1) Among the 4220 cases of male inpatients, 718 (17. 0%) were G. U tract tumors and 39(0. 92%) were testicular tumors. 2) Age distribution was between 8 months and 72 years old, showing the highest incidence under the 5 year-old age group (38%). 3) Twenty one cases (53. 8%) arose on the right and eighteen cases (46. 2%) on the left. 4) Twenty two cases (56. 4%) visited the hospital within 6 months after the onset of the symptoms and 30 cases (77. 1%) within 1 year. 5) The presenting symptoms were painless scrotal mass (79. 5%). painful scrotal mass (7.7%) and metastatic symptoms (12. 8%) 6) Three cases (7.7%) arose from undescended testis. 7) Twelve cases (30. 8%) had already metastasis when first seen. 8) We had measured the level of serum A. F. P. by gel agar precipitation method or radioimmunoassay in 18 cases. Normal levels of A. F. P. were seen it seminoma and nongerminal testicular tumor. Of 11 cases with no metastatic non-seminomatous germinal cell tumor, 5 had elevated serum A. F. P. All the 3 cases with metastatic non-seminomatous germinal cell tumor had elevated serum A. F. P 9) These patients were managed by surgery, radiotherapy and chemotherapy. Serum and urine H. C. G. was checked during chemotherapy on 1 case for the evaluation of response to chemotherapy.
Agar ; Age Distribution ; Aged ; Child, Preschool ; Cryptorchidism ; Drug Therapy ; Humans ; Incidence ; Inpatients ; Male ; Neoplasm Metastasis ; Radioimmunoassay ; Radiotherapy ; Seminoma ; Seoul ; Testicular Neoplasms* ; Urology

We have experienced a rare case of bilateral retinoblastoma in identical twins recently. Their mother noticed that elder sister gazed upward when she fixated some object 5 days ago. On visiting here, we could find out retinoblastoma in both eyes by ophthalmoscopic examination, and younger sister had same fundus. Therefore we enucleated both eye balls of elder sister because of aggrevation of retinoblastoma. Retinoblastoma was confirmed pa thologically. We have been following up periodically younger sister.
Humans ; Mothers ; Retinoblastoma* ; Siblings ; Twins, Monozygotic*

The authers had successfully treated two cases of primary corneal peripheral ischemic syndrome by subconjunctival heparin injection. The first 60 years male patient had a history of a progressive visual disturvance, photophobia and ocular pain in both eyes for 5 months. At the time of his first visit to our hospital, deep ring shaped ulceration at corneal periphery was observed. So he was treated by subconjunctival heparin injection and systemic steroid administration. The second 70 years female patient had a history of Progressive visual disturbance since 3 ears ago and photophobia tearing and ocular pain. At the time of her first to our hospital, deep ring shaped ulceration at corneal periphery was found. So she was treated by subconjunctival heparin injection and systemic steroid administration too. We found no evidence of further ulceration in two cases.
Ear ; Female ; Heparin ; Humans ; Male ; Photophobia ; Ulcer

PURPOSE: To evaluate the NT in the first trimester associated with fetal chromosomal abnormality, fetal structural abnormality and adverse pregnancy outcome. METHODS: From Mar. 1993 to Dec. 1997, 133 cases of increased NT were reviewed retrospectively. All these fetues were taken a karyotyping and/or a high resolution ultrasonography for associated anomaly. The NT was measured by transvaginal ultrasonography(TVS) and transabdominal ultrasonography(TAS) if difficulty was encountered with TVS in the period of the 10th-14th week of gestation. The increased NT is approved when it is over 3mm. RESULTS: Of these 133 cases, 102 cases(76.7%) revealed normal outcomes and 31 cases(23.3%) revealed abnormal outcomes such as chromosomal abnormality, structural abnormality and adverse pregnancy outcome, The mean value of NT was 3.44+/-0.68mm in the normal group and 4.93+/-2.70mm in the abnormal group, respectively. The chromosomal abnormalities were found in 16 of the 31 cases: nine Down SD, two Patau syndrome, one Tuner synrome, one triploidy, one 46, XX,i(18q), one 47,iso(Xp)/46,XX one confined placental mosaicism. In 12 cases of the 31 cases, the structural anomalies were detected. Of these 12 cases, 3 cases were eventually developed to cytsic hygroma, 3 cases were cardiac anomaly, 3 cases were renal anomaly, 1 case was congenital diaphragmatic hernia, 1 case was skeletal dysplasia and 1 case was suspected syndrome. The adverse pregnancy outcome such as intrauterine growth restriction, intrauterine fetal death and preterm labor was revealed in 3 cases. In the cases of NT over 7mm, the result was 100% abnormal outcome. CONCLUSION: Increased NT in the first trimester could be a highly efficient the predictor for detection of chromosomal abnormality, structural anomaly and adverse pregnancy outcome.
Chromosome Aberrations ; Female ; Fetal Death ; Hernia, Diaphragmatic ; Humans ; Karyotyping ; Lymphangioma, Cystic ; Mosaicism ; Nuchal Translucency Measurement ; Obstetric Labor, Premature ; Pregnancy ; Pregnancy Outcome* ; Pregnancy Trimester, First ; Pregnancy* ; Retrospective Studies ; Triploidy ; Ultrasonography

The authors studied the expression of proliferating cell nuclear antigen (PCNA) and the number of argyrophilic nucleolar organizer regions (AgNORs) in 94 cases of various brain tumors and in 5 cases of normal brains. PCN was recognized immunohistochemically in paraffin sections by the monoclonal antibody PC-10. AgNORs could be demonstrated using the silver impregnation method. The PCNA index was not significantly different from the histological grading of glioma(glioblastoma multiforme: 41.40+/-29.14%, anaplastic astrocytoma: 35.00+/-41.02%, and low grade astrocytoma: 22.37+/-30.85%) and there was a wide range of staining even in the same tissue section. However, the AgNORs count per cell correlated well with the pathologic grading of glioma (glioblastoma multiforme : 3.19+/-0.71, anaplastic astrocytoma : 2.06+/-0.16, and low grade astrocytoma : 1.27+/-0.29) with statistical significance. In meningiomas, AgNORs were useful to differentiate benign meningiomas(1.25+/-0.19) and malignant meningiomas(1.78+/-0.35) The authors suggest that the AgNORs count is a faster, less expensive, and a more predictive method in the malignancy of brain tumors than the PCNA immunochemistry expression.
Astrocytoma ; Brain Neoplasms* ; Brain* ; Glioma ; Immunochemistry ; Meningioma ; Nucleolus Organizer Region* ; Paraffin ; Pregnenolone Carbonitrile ; Proliferating Cell Nuclear Antigen ; Silver

OBJECTIVE: To determine the effect of cold air therapy on relieving spasticity, the optimal intramuscular temperature, and the duration of spasticity relief. METHOD: Twenty-three 4 months old Korean white rabbits weighing 2 to 3 kg were used. After posterior laminectomy at thoracolumbar junction, the spinal cord was completely transected. After spasticity occurred, cold air was applied to the triceps surae muscles for 30 minutes at three different intramuscular temperatures (32.5, 30, and 25degrees C). Spasticity was measured pre-treatment, immediately following treatment, after 30 minutes, and after 60 minutes. Clinical parameters (muscle tone, deep tendon reflex, ankle clonus, and Babinski's sign) and electrophysiologic parameters (F/M ratio and H/M ratio) were measured. RESULT: Muscle tone and Babinski's sign significantly decreased immediately following treatment in the 32.5degrees C group, immediately following treatment and after 30 minutes in the 30degrees C and 25degrees C group. Deep tendon reflex and ankle clonus significantly decreased immediately following treatment in the 32.5degrees C group, immdiately following treatment, after 30 minutes in the 30degrees C group, immediately following treatment, after 30 minutes and after 60 minutes in the 25degrees C group. The F/M ratio and H/M ratio were not significantly affected in the 32.5degrees C group but decrease immediately following treatment in the 30degrees C and 25degrees C groups. Compound motor unit action potentials were not evoked in 6 out of 16 cases (37.5%) in the 25degrees C group, resulting in blockage of conduction. CONCLUSION: To relieve spasticity with cold air therapy, the intramuscular temperature should be maintained at 30degrees C. The duration of spasticity relief lasted from 30 minutes to one hour after cold air therapy.
Action Potentials ; Ankle ; Humans ; Infant ; Laminectomy ; Muscle Spasticity* ; Muscles ; Rabbits ; Reflex, Babinski ; Reflex, Stretch ; Spinal Cord ; Spinal Cord Injuries

A case of paraganglioma of cauda equina is presented. This was first described in 1972, since when over 50 cases of this tumor have been described in the world literature. The patient's symptoms were relieved by decompressive laminectomy and subtotal removal of mass with radiotherapy. The pathological examination revealed paraganglioma.
Cauda Equina* ; Laminectomy ; Paraganglioma* ; Radiotherapy

PURPOSE: To determine the MR imaging findings of spinal cord decompression sickness. MATERIALS AND METHODS: We retrospectively analysed the spinal MR images of eight patients (M : 6, F : 2) with decompression sickness affecting the cervical spine (n=1) or thoracic spine (n=7). The observed extent, location, continuity, signal intensity and contrast enhancement pattern of spinal cord lesions were analysed. RESULTS: The chief MR finding was continuous (n=2) or non-continuous (n=3) high signal intensity on T2-weighted images in the posterior paramedian spinal cord. In three cases, additional T2 signal abnormality in the ventral horn of the gray matter was observed. There was no signal intensity abnormality on T1- weighted images or abnormal enhancement on post-Gadolinium T1-weighted images. In one case, cord swelling in addition to T2 signal abnormality was observed. CONCLUSION: MR imaging is useful for evaluating spinal cord lesions in patients with decompression sickness.
Animals ; Decompression Sickness* ; Decompression* ; Horns ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies ; Spinal Cord* ; Spine

Preterm birth (PTB), a pregnancy-related disease, is defined as a birth before 37 weeks of gestation. It is a major cause of maternal mortality and morbidity worldwide, and its incidence rate is steadily increasing. Various genetic factors can contribute to the etiology of PTB. Vascular endothelial growth factor A (VEGFA) gene is an important angiogenic gene and its polymorphisms have been reported to be associated with PTB development. Therefore, we conducted a case-control study to evaluate the association between VEGFA rs699947, rs2010963, and rs3025039 polymorphisms and PTB in Korean women. A total of 271 subjects (116 patients with PTB and 155 women at ≥38 weeks of gestation) were analyzed in this study. The genotyping of VEGFA gene polymorphisms was performed using polymerase chain reaction– restriction fragment length polymorphism. No significant association between the patients with PTB and the control groups was confirmed. In the combination analysis, we found a significant association between PTB and VEGFA rs699947 CC-rs2010963 GG-rs3025039 CC combination (odds ratio, 3.77; 95% confidence interval, 1.091 to 13.032; p = 0.031). The VEGFA rs699947, rs2010963, and rs3025039 polymorphisms might have no genetic association with the pathogenesis of PTB in Korean women. However, the combination analysis indicates the possibility that VEGFA acts in PTB pathophysiology. Therefore, larger sample sets and replication studies are required to further elucidate our findings.