1.Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis.
Zhiyao XU ; Zhuha ZHOU ; Jing ZHANG ; Feichao XUAN ; Mengjing FAN ; Difan ZHOU ; Zhenyu LIUYANG ; Ximei MA ; Yiyang HONG ; Yihong WANG ; Sherven SHARMA ; Qinghua DONG ; Guanyu WANG
Acta Pharmaceutica Sinica B 2021;11(5):1274-1285
Liver is the most common metastatic site for colorectal cancer (CRC), there is no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated the role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage, invasion depth and right-sided primary tumor. Knockdown
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