Objective To study the effect of Qizhen capsule combined with docetaxel injection on the neoadjuvant chemotherapy of breast cancer and its effects on cyclooxygenase (COX-2), cancer antigen 15-3 (CA15-3),and vascular endothelium growth factor (VEGF).Methods 84 patients with breast cancer were selected in our hospital from January 2015 to August 2016, those patients were divided into observation group and control group according to coin method.The control group received docetaxel injection, epirubicin injection, cyclophosphamide neoadjuvant chemotherapy, the observation group was treated with Qizhen capsule on the basis of the control group.The clinical efficacy, COX-2, CA15-3 and VEGF levels, quality of life and adverse reactions were compared between the two groups.Results After treatment, the total effective rate in the observation group (90.48%) was significantly higher than the control group (57.14%) (P<0.05).After treatment, the levels of COX-2, CA15-3 and VEGF in the observation group were significantly lower than the control group (P<0.05).The scores of cognitive function, emotional function, social function, role function and physical function of life quality in the observation group were significantly higher than the control group ( P<0.05 ) .Cardiac toxicity, nausea and vomiting, thrombocytopenia, alopecia, neutropenia and leukopenia were significantly lower in the observation group than the control group (P<0.05). Conclusion Qizhen capsule combined with docetaxel injection can significantly reduce the levels of COX-2, CA15-3 and VEGF in the neoadjuvant chemotherapy of breast cancer, and the clinical curative effect is good, which can effectively improve the quality of life of patients and reduce the adverse reaction rate.

Objective To explore the clinicopathological characteristics,recurrence,metastasis and survival of triple negative breast cancer (TNBC),and to analyze the correlation factors affecting the prognosis.Methods Data of 378 breast cancer patients treated from Jan.2008 to Dec.2011 were retrospectively analyzed.According to immunohistochemical staining of estrogen of receptor (ER),progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2),they were divided into TNBC group (61 cases) and non-triple negative breast cancer group (non-TNBC,317 cases).The two groups were compared in terms of clinicopathological characteristics,prognosis and survival.Results Patients in TNBC group had significant differences in the following aspects:ratio of patients with newly diagnosed age ＜35 years old,patients with family history of breast cancer,the maximum diameter of tumor more than 5 cm,positive preoperative axillary lymph node status,tumor in clinical stage m,histological grade of tumor in level Ⅲ,Ki67 overexpression and P53 overexpression,while there was no statistical difference in the aspects of menstrual status,pathological type or surgical method between them.The local recurrence and distant metastasis rate were obviously higher in TNBC group than in non-TNBC group.5-year diseasefree survival (DFS) and 5-year overall survival (OS) were significantly lower in TNBC group than in non-TNBC group.Univariate analysis showed that factors related to 5-year DFS in TNBC group were:age,the maximum diameter of tumor,the preoperative axillary lymph node status,clinical staging of tumor,and P53 overexpression.The maximum diameter of tumor,the preoperative axillary lymph node status and clinical staging of tumor were recognized as the influence factors of 5-year OS.Independent factors affecting 5-year DFS in TNBC group were:the maximum diameter of tumor,and the preoperative axillary lymph node status.The maximum diameter of tumor and the preoperative axillary lymph node status were the independent factors influencing 5-year OS.Conclusions The clinicopathological characteristics of TNBC include:younger onset age,family clustering of breast cancer,the larger maximum of tumor diameter,larger portion of positive preoperative axillary lymph node,later clinical staging of tumor,higher histological grade of tumor,easier local recurrence and distant metastasis,lower 5-year DFS and 5-year OS.The factors of age,the maximum diameter of tumor,the preoperative axillary lymph node status,clinical staging of tumor,P53 overexpression especially the maximum diameter of tumor and the preoperative axillary lymph node status play the important clinical roles in judging the prognosis of TNBC.