Objective To observe the effect of the aloe juice reducing skin injury of face and neck caused by radiotherapy in nasopharyngeal cancer patients. Methods Eighty nasopharyngeal cancer patients admitted in hospital from March 2007 to January 2009 were randomly recruited into a control group and a treatment group. The treatment group (n=48) was treated by smearing on face and neck skin with aloe juice after the conventional fractionation radiotherapy. The control group (n=32) received no therapeutic measures after the conventional fractionation radiotherapy. Results In the treatment group there were 21 patients and 13 patients had I degree and II degree of skin lesion respectively; and in the control group, there were 5 patients and 10 patients had the I degree and II degree of skin lesion respectively. There was a significant difference between the two groups (χ~2= 10.6. P<0.05). Conclusion Aloe juice can reduce the injury of skin caused by radiotherapy.