Objective: To study the preoperative blood glucose management model and its implementation effect in the multidisciplinary team of ophthalmology under the background of diagnosis related groups (DRGs). Methods: A total of 170 patients underwent vitrectomy, vitreous injection, and cataract extraction surgery were enrolled in the CS03Z and CS09A groups from January 1, 2018 to December 31, 2018. The cases from January 1, 2018 to June 31, 2018 were in the control group, accounting for 76 cases, and routine blood glucose management was performed. The cases from July 1, 2018 to December 31, 2018 were observed in the observation group, and 94 cases were implemented. The multidisciplinary blood glucose management model was implemented. The average hospitalization days, average hospitalization costs, preoperative blood glucose management quality, and hospitalization satisfaction were compared between the two groups. Results: In the control group, the average hospitalization cost of the three operations (PPV/IV/Phaco group) was (13 949.71±2 099.36) yuan, (4 933.22±2 269.33) yuan, (6 521.16±1 006.40) yuan, the average hospitalization cost of the three operations of the observasion group was (12 937.37±1 447.33) yuan, (2 649.53±1 105.92) yuan, (5 315.76±1 037.02) yuan, the difference between the two groups was statistically significant (t=2.266, 3.818, 4.074, all P<0.05 or 0.01) . The average hospitalization day of the 3 operation group was (9.98±3.91) d, (9.63±5.46) d, (7.65±3.88) d, and the observation group was (6.37±3.54) d, (3.97±2.29) d, (4.17±2.23) d,the difference between the two groups was statistically significant (t=3.980, 3.979, 3.632, all P<0.01). The preoperative blood glucose accident rate in the control group was 14.47% (11/76), The observation group was 2.13% (2/94), the difference between the two groups was statistically significant (χ²=11.642, P<0.01). The surgical delay rate of the control group was 2.63% (2/76) ; the surgical delay rate of the observation group was 0(0/94), the difference between the two groups was statistically significant (χ²=7.045, P<0.01) .The nurse blood glucose management of the control group was 66.67% (24/36) , and that in the second half was 97.22% (35/36) ,the difference between the two groups was statistically significant (χ²=9.005, P<0.01). The satisfaction rate of the patients in the control group was 82.89% (63/76), and that of the observation group was 94.68% (89/94). the difference between the two groups was statistically significant (χ²=6.166, P<0.05). Conclusion Under the background of DRGs, the preoperative multidisciplinary blood glucose management team with clinical pathway as the core can effectively reduce the average hospitalization cost and average hospitalization day, improve the quality of blood glucose management, and improve the hospitalization satisfaction of the patients.