Objective To compare the effects of CalliSpheres drug-eluting beads transcatheter arterial chemoembolization(DEB-TACE)and conventional TACE(c-TACE)on liver fibrosis and liver function in the treatment of primary hepatocellular carcinoma(HCC).Methods A total of 40 patients diagnosed with HCC at Xuzhou Municipal Cancer Hospital of China between October 2020 and October 2022 were enrolled in this study.According to therapeutic scheme,the patients were divided into DEB-TACE group(n=20)and c-TACE group(n=20).The preoperative,and postoperative 5-day and one-month hyaluronidase(HA),type Ⅲ procollagen peptide(P Ⅲ NP),type Ⅳ collagen(CⅣ)and laminin(LN),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil),albumin(Alb),and prothrombin time(PT)were compared between the two groups.Results The technical success rate was 100％in both groups,and tumor staining completely disappeared immediately after TACE in all patients.The postoperative 5-day levels of HA,LN,P Ⅲ NP,and CⅣ in both groups were remarkably higher than the preoperative ones(P＜0.05).One month after TACE,HA level in the DEB-TACE group was prominently higher than its preoperative value(P＜0.05);HA and LN levels in the c-TACE group were obviously higher than their preoperative values(P＜0.05);and the HA and LN levels in c-TACE group were significantly higher than those in DEB-TACE group(P＜0.05).Five days after TACE,in the DEB-TACE group the AST and PT levels were higher than their preoperative values while the Alb level was lower than its preoperative value(P＜0.05);in the c-TACE group the ALT,AST,TBiL and PT were higher than their preoperative values while the Alb level was lower than its preoperative value(P＜0.05);the ALT and AST levels in the c-TACE group were strikingly higher than those in the DEB-TACE group while Alb level was strikingly lower than that in the DEB-TACE group(P＜0.05).Conclusion Both CalliSpheres DEB-TACE and c-TACE can aggravate liver fibrosis and cause liver function damage.However,the degree of liver fibrosis and liver function damage caused by CalliSpheres DEB-TACE is less than that caused by c-TACE.(J Intervent Radiol,2024,33:259-263)

OBJECTIVE：To study the h ypoglycemic effect of Hordeum vulgare polysaccharide（HVP）on diabetes mellitus model mice and its mechanism. METHODS ：The mice were given intraperitoneal injection of streptozotocin （120 mg/kg）to induce diabetes mellitus model. After modeling ，the mice were randomly divided into model group ，metformin group （positive control ， 200 mg/kg），HVP high-dose ，medium-dose and low-dose groups （300，150 and 75 mg/kg），with 10 mice in each group. Blank control group was established additionally. Administration groups were given relevant medicine intragastrically ；blank control group and model group were given constant volume of water intragastrically ，once a day ，for consecutive 30 days. The levels of fasting blood glucose （FBG）were determined after 10，20，30 days of administration. After last FBG test ，mice were intraperitoneally injected with 10％ glucose solution （2 g/kg），then the area under the glucose tolerance （GTT）curve was measured at 30 and 120 min after injection. The serum levels of insulin ，the content of superoxide dismutase （SOD），glutathione peroxidase （GSH-Px）， malondialdehyde（MDA）in liver tissue were detected. Pancreatic morphology of mice were detected by HE staining. RESULTS ： Compared with blank control group ，the FBG ，area under GTT curve and MDA contnet in liver tissue were increased significantly in model group （P＜0.01），while serum levels of insulin ，SOD and GSH-Px contents in liver tissue were decreased significantly （P＜0.01）；the pancreatic tissue was seriously damaged with incomplete morphology and obvious vacuoles. Compared with model group，FBG，area under GTT curve ，MDA content in liver Δ 基金项目：国家自然科学基金资助项目（No.81473179） tissue were decreased significantly in HVP high-dose group ＊主管药师 。研究方向 ：临床药学 。电话：0510-85351490。E- mail：Wangshengya_helen@126.com （P＜0.05 or P＜0.01），serum content of insulin ，the content # 通信作者 ：副主任药师 。研究方向 ：医院药学 。电话：0510- of SOD and GSH-Px in liver tissue were increased 85351490。E-mail：3103221944@qq.com significantly（P＜0.05 or P＜0.01）；above indexes of HVP 中国药房 2021年第32卷第7期 China Pharmacy 2021Vol. 32 No. 7 ·807· low-dose and medium-dose groups were improved partially ，with statistical significance （P＜0.05 or P＜0.01）；the pancreatic tissue damage was alleviated ，the morphology was relatively complete ，the islet cells were closely arranged ，and the vacuoles were reduced. CONLUSIONS ：HVP can reduce the level of blood glucose in diabetic model mice ，increase insulin level and relieve pancreatic injury. The mechanism may be related to its antioxidation.