Objective:To analyze CT and MRI manifestations of cranium and spinal column with neurofibromatosis type1 and 2 to improve the diagnostic accuracy.Methods:CT and MRI images of 16 cases of neurofibromatosis confirmed by clinics and pathology were analyzed retrospectively.2 cases were examined by CT and 14 cases by MRI.There were 6 cases of NF1 and 10 cases of NF2.The abnormal CT and MRI manifestations of the lesions were analyzed.Results:NF1 manifestations were as follows:5 cases of multiple schwannomas were displayed on MRI with intraspinal and paraspinal lesions,and along with 1 case of syringomyelia,2 cases of right great psoas muscle schwannomas.1 case had defect of right great wing of the sphenoid on CT.NF2 manifestations were as follows:5 cases had bilateral acoustic neuromas and multiple meningioms,and with 2 cases of multiple neurofibromas in the occipital,cervical and lumbar soft tissues;2 cases of bilateral internal auditory canal enlarged on CT;1 case of choroid plexus in the lateral ventricle abnormal calcification,1case of right troehlear nerve schwannoma.5 cases had single acoustic neuromas,with 3 cases of schwannomas in spinal canal,and 1case of intramedullary cervical spinal cord ependymoma and syringomyelia;3 cases of multiple meningioms and with 1 case of schwannoma on the facial nerve,vestibular and trigemina nerve;and 3 cases had abnormal signal lesions in the brain parenchyma.Conclusion:Neurofibromatosis type 1 and 2 had characteristic CT and MRI manifestations in cranium and spinal column,which could be diagnosed correctly in clinic.

ObjectiveTo improve imaging teaching of the central nervous system ( CNS ) by applying picture archiving and communication system ( PACS ).MethodsFifty medical imaging undergraduate students were arranged to study the content of CNS by introduction training about PACS,postprocess viewing cerebral stenosis and aneurysm by practicing,studying by searching the disease and browsing teaching picture archiving.ResultsStudents could master the content efficiently and enhance their initiative and creativity.ConclusionPACS has an important value in the imaging teaching of CNS.

Objective To analyze the laboratory determination results of hand-foot-mouth disease(HFMD)and explore its sig-nificance.Methods Pharyngeal swab specimens were collected from 502 children with HFMD(severe case:104 cases and mild case:398 cases).Specific RNA of enterovirus primer(EV),enterovirus71 (EV71)and coxsackievirus A16(CA16)were detected by real-time fluorescence polymerase chain reaction(RT-PCR).Simultaneously,white blood cell (WBC),direct bilirubin(DBIL),alanine transarninase(ALT),creatine kinase MB isoenzyme(CK-MB)and lactic dehydrogenase (LDH )were determined,and the results were analyzed.Results Among the 502 children,384 cases were positive for EV,262 cases were positive for EV71,and 39 cases were positive for CA16.The positive rates were 76.49%,52.19% and 7.76%,respectively.In the 104 HFMD severe cases,EV71 positive rate was 92.31%(96/104).There were clearly more boys than girls.The age distribution was mainly in the group under 3-year-old(402 cases,80.08%).In the group under 3-year-old,there were 97 severe cases(93.27%),and the EV71 positive rate was 92.78%(90/97).Serum levels of WBC,DBIL,ALT,CK-MB and LDH were higher in severe HFMD group than in mild group(P <0.05).Conclusion The HFMD occurred mostly at the children under 3-year-old.The HFMD appeared is mainly related to the EV infection,and EV71 is the main pathogen causing the severe cases of HFMD.

Objective: To explore the distribution characteristic of syndromes and the rule of the differentiation of symptoms and signs of functional dyspepsia(FD).Methods: We investigated and analyzed the 565 cases of FD by the epidemiological ascertainment methods,and had the second differentiation of symptoms and signs by "cold,heat,deficiency,exc ess" on the basis of the traditional method,then established the database and had a statistical analysis by SPSS.Results: Based on the differentiation of symptoms and signs of "cold,heat,deficiency,excess",FD could be mainly classified as asthenia cold syndrome-insufficiency(or deficiency-cold) of the spleen and stomach,excess-heat syndrome dampness-heat of spleen and stomach,deficiency-excess complicated syndrome spleen-deficiency and qi stagnation,and cold-heat complicated syndrome.Conclusion: It is a brief,clear and also feasible method for the differentiation of symptoms and signs of FD with the class of "cold,heat,deficiency,excess".

Objective To evaluate the efficiency and safety of hair removal in different areas with Lightsheer Duet diode laser and to compare clinical effect and safety in axillae hair removal between the two models,high-speed and standard model.Methods Lightsheer Duet diode laser was used to remove hairs from different areas in 200 cases,for 4-8 weeks treatment 1 time,4 times for 1course.The curative effect and adverse reaction were observed after the treatment.Thirty axillae hair removal subjects were chosen randamly and received treatments using the different models,high-speed hand piece on one side and the standard hand piece on the other side.Hair removal efficiency and the immediate pain were compared and evulated on each subject.Results The hair was significantly reduced after 4 times treatments in 200 cases.The total effective rate was 95.54 ％ and positively related with the treatment times.Pigmentation was found in 3 cases,but it disappeared after 1-3 months.The total effective rate was 100 ％ after the 3 times treatments in axillae hair removal subjects both using the high-speed model or the standard model in 30 cases.There was no statistical difference between the two models except less pain in the high-speed model.Conclusions Lightsheer Duet diode laser is a safe and efficient method in hair removal.The high-speed model has more advantage on speed and causing pain.

Objective To highlight the role of physician's experience in physical examination for the early diagnosis of breast cancer.Methods Data of physical examination of mammary glands in 1785 female were analyzed and compare with the uhrasonography and mammngraphy results.Results Of the 31 breast cancers confirmed by pathologic examination after operation,2 cases were bilateral breast cancers and 1 was nonpalpable.9 of 41 cases which suspected by inspection were confirmed as breast cancers.The significant difference was found comparing with control group by X2 test (X2=100.5,P＜0.05).The 34 breast cancers were found in 2089 focus in palpation and there were 6 minimal cancers (diameter≤1.0 cm) among them.Some cancers were found in special location with no malignant clinical manifestation.The rate of missed diagnosis of ultrasonography and rnammography is 16.1% and 19.4%,respectively.Conclusions Physical examination plays an important role in the early detection of breast cancer and physician's experience is a major determinant for avoiding misdiagnosis.

With the constant change of medical electronic instruments ( MEI ) professionals' needs,the professional personnel training programs need to be adjusted and improved.Based on the analysis of the MEI professional students'employment situation,this article discusses several key issues of the personnel training program,and puts forward some suggestions of improving the MEI professional's personnel training program,in combination with the actual running in the training,the training objective,course arrangement,practice teaching etc..

10.3969/j.issn.2095-4344.2013.26.007

Objective To explore a novel long-circulating dual-receptor targeting and dual-modal molecular probe and investigate its physicochemical properties and targeting effect on breast cancer cells in vitro. Methods Dual-receptor targeting and dual-modal molecular probe RGD@BBN-lipo(QDs)-SPIO was synthesized in the following steps: long-circulating liposome was prepared by film dispersion method;water-soluble superparamagnetic iron oxide (SPIO) nanoparticles and Quantum dots (QDs) were loaded in the hydrophilic and hydrophobic layer of liposome, respectively;RGD and BBN polypeptides were coupled on the former functional magnetic/fluorescent liposomes. Stability of the probe in different physiological solutions was investigated. Transmission electron microscopy (TEM) and particle size analyzer were used to measure nanoparticle sizes and the Zeta potential. Characterization of RGD and BBN was investigated through 1H-NMR and elemental analysis. The MRI T2 relaxivities (1/T2) of RGD@BBN-lipo(QDs)-SPIO was measured through T2 map scanning on 3.0 T MR system. HUV-EC-C cells were used for assessment of cells viability by MTS assay. Prussian blue staining and fluorescence imaging were carried out to determine the targeted breast cellular uptake of RGD@BBN-lipo(QDs)-SPIO nanoparticles. Results The targeting magnetic/fluorescent dual-model molecular probes appeared spherical or para-spherical,with a mean diameter of(118.2±3.9)nm,Zeta potential of (-24.78±1.68) mV,MR T2 magnetic relaxation rate of 0.498 1× 106 M-1 · s-1.RGD and BBN polypeptides were successfully coupled on the former functionally magnetic/fluorescent liposomes with the bind rates of 33.05%and 45.06%, respectively. There was low cytotoxity of the molecular probe on human umbilical vein endothelical cells(HUV-EC-C)by MTS study. Prussian blue staining and fluorescence imaging studies showed that the RGD@BBN-lipo(QDs)-SPIO nanoparticles could target any αvβ3 or gastrin releasing peptide receptor overexpression breast cancer. Conclusions RGD@BBN-lipo(QDs)-SPIO is a novel long-circulating dual-receptor targeting and dual-modal molecular probe and has excellent physicochemical properties and stability, high T2 relaxivities and strong targeting effect on cancer cells and has laid a solid foundation for early diagnosis of breast cancer.

To investigate CT features of palatal malignant tumors and to evaluate, CT diagnostic value. CT manifestations of 32 cases of palatal malignant tumors were analyzed retrospectively. All cases were confirmed by pathology. There were 27 males and 5 females between 23 and 80 years of age. Axial contrast enhancement CT scan was performed in all cases, among them, nonenhancement CT scan was also performed in 8 cases and coronal CT scan was performed in 2 cases. The main signs of palatal malignant tumors were as follows: (1) Masses in palate in 26 cases, thickened palatal soft tissue in 6 cases and destruction of palate bone in 8 cases. The lesions were located in soft palate in 22 cases, in hard palate in 4 cases, and in the junction region between soft and hard palate in 3 cases; (2) Other adjacent structures and organs were involved in 27 cases; (3) Lymph nodes of neck metastasis were demonstrated in 17 cases. CT is an excellent technique, which can show the gross pathologic features and the invasion pathway of palatine malignant tumors, and it can provide some important information for the relevant clinical treatment and prognosis.
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell ; diagnostic imaging ; secondary ; Female ; Humans ; Image Enhancement ; Lymphatic Metastasis ; Male ; Middle Aged ; Palatal Neoplasms ; diagnostic imaging ; pathology ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed