Forty four patients (84 eyes)with primary chronic angle closure glaucoma,including 14 cases(26 eyes)with mild visual field defect,22 cases(42 eyes)with moderate defect and 8 cases(16 eyes) with severe defect,treated in our hospital from January 2014 to January 2016 were enrolled in the study.The visual field defect (MD),corneal endothelial cell density (ECD) and central corneal thickness (CCT) were measured.The average CCT in mild,moderate and severe visual field defect groups was (531.4 ± 27.1) μm,(521.2 ± 31.4) μm and (513.3 ± 28.2) μm,respectively (F =-3.24,P =0.04).The mean endothelial cell density in three groups was (2 635.0 ± 320.3) cells/mm2,(2 619.2 ± 161.4) cells/mm2 and(2 589.7 ± 290.4) cells/mm2,respectively (F =0.22,P =0.80).The results indicate that with the aggravation of visual field defect in patients with chronic angle closure glaucoma,the central corneal thickness is significantly thinner,and the mean density of central corneal endothelial cells shows a downward trend.Close observation and active intervention are needed for chronic angle closure glaucoma with thin central corneal thickness.