Abstract As a common critically illness among neonates and notably premature infants, respiratory failure is one of the major factors for neonatal deaths. Ventilator, an effective tool for assisted ventilation, is effective to remarkably improve respiratory failure; however, the conventional mechanical ventilation is likely to cause a series of injuries and complications. Therefore, noninvasive ventilation is commonly used in clinical practices. Noninvasive high-frequency oscillatory ventilation is an emerging noninvasive respiratory, in which tracheal intubation is replaced with nasal plug and mask to transfer high-frequency airflow to the airway. It facilities rapid correction of the imbalance of ventilation blood flow ratio, reduction of carbon dioxide retention, increase in oxygen saturation, and reduction in incidence of complications and risk of failure in ventilator withdrawal, which has been employed for the treatment of respiratory failure among neonates. The review descries the applications of noninvasive high-frequency oscillatory ventilation in respiratory support among neonates with respiratory failure, so as to provide insights into the management of respiratory failure among neonates.