Objective To review the prenatal ultrasonographic evaluation on fetal midline facial defects of holoprosencephaly. Methods Twenty-four facial malformations of 14 cases with alobar/semilobar holoprosencephaly from August 2000 through April 2004 were reviewed to determine and classify the associated facial abnormalities detected with prenatal sonography. Results There were 24 facial abnormalities in 14 cases with alobar/semilobar holoprosencephaly. Facial abnormalities were present in all cases and were detected in 22 ( 91.7%) of 24 facial malformations on prenatal sonography. One or more extrafacial anomalies were present in 8 ( 57.1%) of 14 fetuses. Conclusions Prenatal sonographic evaluation of midline facial defect may allow more definitive diagnosis of alobar or semilobar holoprosencephaly.

Background and Object: Percutaneous coronary intervention (PCI) on ostial lesions in coronary arteries associated with higher procedural difficulty and complication morbility. It has been technically difficult because it should be done with precise stent placement in ostium and absence of side branch compromise. The Szabo technique consists of side branch wiring through most proximal stent strut as well as main branch wiring through stent lumen. The side branch wire or anchor wire prevents stent advancement beyond ostial segment and makes possible the accurate stent implantation in ostium. The purpose of this study is to evaluate the safety, feasibility and success rate of Szabo technique by analysing technical, angiographic and IVUS (Intravascular Ultrasonography) findings. Methods: The data of 39 PCIs in 39 patients with a significant lesion at a coronary artery ostium which was treated percutaneously using Szabo technique were retrospectively analysed. The technically successful procedure was defined as there was neither stent loss nor second guide wire pull back during stent advancement. A successful procedure from angiographic point of view was defined as a precise stent implantation at ostium without side branch compromise. Successful procedure from IVUS point of view was defined as accurate stent placement in ostium without proximal protrusion and without any stent uncovered area. A total of 39 patients was with 28 males and 11 females. They aged from 43 to 79 years with a mean age of （65±12）years. The 6F and 7F guiding catheter were used in 35 (89.7%) and 4 (10.3%) patients separately. The access was radial in 31 (79.5%) and femoral in 8 (20.5%) patients. The culprit vessel was left anterior descending (LAD) in 26(66.7%), right coronary artery (RCA) 5 (12.8%), circumflex-obtuse marginal (LCX-OM) 3(7.7%), and posterior descending (PDA) 5(12.8%). IVUS was performed through culprit vessel in 30 (76.9%) and was also done in side branch in 9 (23.1%) patients after stent implantation. Results The procedure was technically successful in 36 (92.3%) patients. All technically successful patients had angiographic success (100%). IVUS examination of culprit vessel showed accurate stent placement in ostium 29 (96.7%) and slight stent proximal protrusion in 1(3.3%) patients. No serious complication occured. Conclusions This study shows that Szabo technique is safe and feasible for PCI in ostial coronary artery lesions with a high angiographic success rate，its deserved to spread.

Objective To observe the respiratory system adverse drug reaction ( AREs) in obese patients in anesthesia recovery incidence and treatment outcome .Methods This was a control prospective trial .Study was con-ducted on 27 cases of obesity and the same amount of normal with body mass index (BMI)<30(control group).The sex distribution ,age and the type of operation and operation was similar between the two groups .The hospitalization rate of AREs in PACU was observed .Descriptive analysis on the variables ,use Mann-Whitney U,compared with chi square test and Fisher exact test of variables .The relationship between variables and AREs was studied by using uni-variate and multivariate Logistic retrospective analysis .Results Obese patients with the STOP-Bang≥3 ( 89% vs 11%,P<0.001)occur more frequently,obese patients had a lower rate of underwent high risk operations (7% vs 41%,P=0.005) and big operation (4% v s15%,P=0.008).Obesity in PACU patients were more susceptible to getting AREs(33% vs 7%,P<0.018).Multivariate analysis indicated that obesity and residual muscle relaxation effect was the independent risk factors of AREs .Obese patients in PACU had a longer periods of time treatment (120min vs 84min,P<0.001).Conclusion Obesity is an independent risk factor for PACU in patients with AREs . Obese patients in PACU were treated time more longer .

Objective To explore the clinical characteristics and prognosis of apical hypertrophic cardiomy -opathy (AHCM).Methods A retrospective analysis was performed on the clinical data of 34 patients with AHCM, the clinical characteristic , ECG, imageology data and the cardiovascular morbidity were counted and analyzed . Results There was no specificity on the clinical characteristics of the patients with AHCM ,the high voltage of the left ventricular and the huge inverted T wave of the left precordial leads came into the characteristic change for the ECG,there were 21 patients of the total 34 patients were made a definite diagnosis after examined by the ultrasonic cardiogram,13 patients of them were made a definite diagnosis after examined by MRI .During the following-up,there were 4 patients occurred angiocardiopathy (the morbidity was 11.8%).The thickness of apex,apex cordis and poste-rior wall of the left ventricle examined during the last follow-up had significant differences compared with that during the first diagnosis(t=-3.73,-3.908,all P<0.05).The left ventricular ejection fraction ,interventricular septal thickness,left ventricular end diastolic diameter and thickness of the posterior wall of left ventricle had no significant differences compared with that during the first diagnosis (t =1.762,1.662, -1.857,2.015,all P >0.05). Conclusion AHCM has the benign prognosis effect , but the clinical misdiagnosis rate is high , clinicians should enhance their understanding level on the disease ,the characteristic ECG change ,ultrasonic cardiogram and MRI check can help to make a definite diagnosis .

The -1031T/C polymorphism of tumor necrosis factor-? (TNF-?) gene was determined by PCR-RFLP in 54 patients with thyroid-associated ophthalmorpathy (TAO), 60 patients with autoimmune thyroid disease (AITD) without ophthalmopathy and 76 healthy subjects. The results showed that the frequencies of TC+CC genotype and C allele in TAO group, especially in male patients, were significantly higher than those in the other two groups (both P

Objective To solve the problem of erectile dysfunction in clinical forensic medicine investigation by using the nocturnal penile tumescence (NPT) testing. Method 13 cases who complained erectile dysfunction after trauma were studied by using RIGISCAN PLUS SYSTEM. Results In 13 cases, the results of NPT testing showed that the erectile function was normal in 3 cases, slight dropping in 5 cases, medium dropping in 2 cases, and completely losing in 3 cases. In 5 cases which were serious erectile dysfunction as tested by IIEF, the NPT showed that the erectile function was normal in 1 case, slight dropping in 1 case, medium dropping in 1 cases, and losing completely in 2 cases. Conclusion The nocturnal penile tumescence testing can solve the problem of erectile dysfunction in forensic medicine investigation including the estimatieon of the severity of injury, labor ability assessment and some related questions.

Objective Study of the feasibility that the former changing trend of tumour after the first BAI can forecast the later curative effect on tumour.Methods Bronchus artery and relational body arteries opacification and BAI have been introduced in 82 primary pulmonary carcinoma cases.In the statistic analysis,SPSS 13.0 for Windows Stat.Software Package has been used.At the meanwhile chi square test,one-sample t-test,GLM-univariate analysis have been adopted as well to study the relationship between the former changing trend of tumour and Later Curative Effect after BAI in mid-advanced stage pulmonary carcinoma.Result There are significance statistical significances between the former changing trend of tumour and the later curative effect after the first BAI in mid-advanced stage pulmonary carcinoma.Conclusion The former changing trend of tumour after the first BAI is the factor influencing the later curative effect.

Objective To study later eurative effects after BAI with single factor analysis.MethodsBronchus artery and relational body arteries opacification and BAI had been introduced in 82 primary pulmonary carcinoma cases.In the statistic analysis,SPSS 13.0 had been used.ResultsThe tumour blood supply types and the times of effective BAI treatment were the factors influencing the later treatment period.Tumour pathologic types,the branches of tumour blood supply,tumour clinic cTNM stages,chems project influenced faintly later curative effect.ConclusionThe blood supply types of primary pulmonary carcinoma and the times of effective BAI treatment are the factors influencing the later treatment period.

Low intensity millimeter(6mm,50GHz,100mW) wave was used to irradiate to 15 blood samples. The radiation time respectively were 15min、30min and 60min.Series rheological and biophysical parameters about the erythrocyte were systemically tested. There included viscosity of blood 、deformability and congregating ability of erythrocyte、hemolysical fragility 、anion transport in erythrocyte membranes and configuration of erythrocyte etc. From the point of biophysics, the biological effects of low intensity MMW to cells were investigated.

Fast track surgery(FTS)is an idea and theory which has widely used in the surgical operations,through the whole treatment of patient' s surgery. A series of positive measures has been adopted, FTS has ameliorated the velocity of the rehabilitation and prognosis after operation, and improved the quality of life and the therapeutic effect. We reviewed the new concept and the application prospect of FTS in the gastrointestinal surgery in this article.