1.Research progress of ocular decompressive retinopathy
International Eye Science 2019;12(7):1142-1145
Ocular decompression retinopathy(ODR)is defined as multiple hemorrhagic retinopathy following abrupt lowering of intraocular pressure(IOP)that is not explained by another process. It is frequently associated with glaucoma surgeries, but also occurs in conjunction with other ocular surgical or medical procedures. Most patients are asymptomatic, so it may be difficult to detect clinically. We review the recent articles to better understand the risk factors, pathogenesis, clinical characteristics, imaging, differential diagnoses, management and prognosis of ODR.
2.Status and impact factors of mental symptoms in schizophrenics at home in Jinshan District of Shanghai
Lian-lian NIE ; Sheng-qiong PAN ; Long-hui WU
Shanghai Journal of Preventive Medicine 2020;32(7):587-
Objective To analyze the current status of mental symptoms and related influencing factors in patients with schizophrenia, and to provide reference for helping patients achieve better home rehabilitation. Methods Cluster extraction was done of 371 home schizophrenia patients registered in the community, and follow-up surveys were carried out for general demographic data, family status, current status of the disease, and treatment status.Univariate and multivariate logistic regression analysis was used for each factor in affecting the patient′s mental symptoms. Results All of the 371 patients completed follow-up surveys, and 121 patients with positive psychotic symptoms (positive rate 32.61%).Univariate analysis showed that differences in the economic situation, course of illness(years), risk behavior level, self-knowledge, hospitalization and working status were statistically significant (
3.Expression and action of vascular endothelial growth factor and its receptor in a rat model of retinopathy of prematurity.
Xian-qiong LUO ; Guo-sheng LIU ; Ri-quan LAI ; Chuan NIE ; Kun-he WU ; Ye TIAN ; Ming-han XIA ; Ju-ling KANG
Chinese Journal of Pediatrics 2004;42(7):511-515
OBJECTIVETo explore the expression of vascular endothelial growth factor (VEGF) and its receptors (flt-1 and flk-1) in the retina of retinopathy of prematurity (ROP), and its relation to the alteration of retinal blood vessels.
METHODSEighty-six newborn Sprague-Dawley rats were randomly divided into hyperoxia and air groups, then each group was further divided into 1, 3, 7 and 14 days subgroups. The rats in hyperoxia group inhaled 75% oxygen and ROP model was thus set up. These animals were sacrificed respectively after 1, 3, 7 and 14 days, then the retinal endothelial cells were marked by CD34 to observe the change of retinal blood vessels. The expression of VEGF, flt-1 and flk-1 in the retina was measured by immunohistochemistry.
RESULTSThe retinal capillary density index (RCDI) in control group increased as days went on (F = 21.589, P < 0.01, but it was the least on the 7th day in hyperoxia group, after the rats had been returned to air for 7 days, RCDI increased significantly (F = 67.885, P < 0.01); In the control group, the expression of VEGF and flk-1 was the strongest in the retina on the 7th day, the result had significant difference as compared with the 1st and 14th day (P < 0.05). The expression of VEGF and flk-1 on the 7th day in hyperoxia group was weaker than that of control group (P < 0.05). But on the 14th day in hyperoxia group, they were stronger than that of control (P < 0.05). The localization of the expression of flt-1 was changed when blood vessels altered, but there was no significant difference in expression intensity as a whole (P > 0.05).
CONCLUSIONWhen the premature retina was exposed to hyperoxia, the expression of VEGF and flk-1 was reduced, and retinal blood vessels were also decreased; but the expression of VEGF and flk-1 was stronger in retina when premature rats were exposed to relative hypoxia, and the retinal blood vessels also increased significantly. It is concluded that VEGF and flk-1 may play important roles in the development of retinal blood vessels and its change in ROP. However, flt-1 has less effect compared with flk-1.
Animals ; Animals, Newborn ; Disease Models, Animal ; Female ; Hypoxia ; Immunohistochemistry ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Vascular Endothelial Growth Factor ; analysis ; Retina ; chemistry ; pathology ; Retinal Diseases ; metabolism ; pathology ; Vascular Endothelial Growth Factor A ; analysis
5.Clinical characteristics of pediatric hemorrhagic fever with renal syndrome.
Hong-Wei MA ; Tie-Jian NIE ; Yong-Tao MA ; Ya-Qiong WU ; Zhan-Sheng JIA ; Xue-Fan BAI
Chinese Journal of Contemporary Pediatrics 2014;16(11):1091-1095
OBJECTIVETo study the clinical characteristics of pediatric hemorrhagic fever with renal syndrome (HFRS), and to improve its understanding so as to reduce the misdiagnosis.
METHODSA retrospective analysis was performed on the clinical data of 26 children with HFRS between January 2009 and December 2012.
RESULTSThe age of disease onset was mainly distributed between 7 and 14 years (23 cases, 88%), and the male-to-female ratio was 1.89:l. The clinical manifestations of pediatric HFRS varied. The early symptoms resembled those of a cold, and in the course of HFRS, most patients developed digestive symptoms such as vomiting and abdominal pain. The laboratory examinations usually implicated platelet changes, and the imaging examinations revealed polyserous effusions. The prominent complication was myocardial injury.
CONCLUSIONSPediatric HFRS mainly occurs in school-age children, more commonly in males. HFRS does not have typical clinical manifestations or symptoms, so it should be distinguished from cold or appendicitis at the early stage. When applying the fluid replacement therapy, the cardiac function should be carefully monitored in case of heart failure.
Adolescent ; Child ; Child, Preschool ; Female ; Fluid Therapy ; Hemorrhagic Fever with Renal Syndrome ; diagnosis ; therapy ; Humans ; Male ; Retrospective Studies
6.Application of complex networks model in preventing and controlling communicable disease
Shu-Qiong HUANG ; Sheng WEI ; Li YUE ; Hao XIANG ; Li LIU ; Li LIU ; Xiu-Min GAN ; Chuan XU ; NIE
Chinese Journal of Epidemiology 2009;30(4):402-406
To discuss the application of complex networks models in preventing and controlling communicable disease, analyze and control the spread of infectious diseases by using the models and the software of complex networks based on its basic properties. Compared with conventional epidemiological approach, the complex networks theory, as a new theory, not only can describe the dynamic process of infections diseases spreading but also forecast the situation of infectious disease. The influence of the network's topology on the infections diseases transmission can be deeply understood through the research on disease spreading by its theory, so to control the spread of diseases. Complex networks theory approach can be used in epidemiological research for having much advantage compared with those conventional epidemiological approaches.
7.The Value of Blooming Sign on MRI in Distinguishing Malignancy from Benign Small Breast Masses and Its Radiologic-pathologic Correlation Analysis
Chan LAI ; Zhuang-sheng LIU ; Ru-qiong LI ; Ke-ming LIANG ; Wan-sheng LONG ; Hai-cheng LI ; Zhong-xin NIE
Journal of Sun Yat-sen University(Medical Sciences) 2022;43(2):321-330
ObjectiveTo determine the value of MRI blooming sign in differentiating benign and malignant small breast masses and investigate its radiologic-pathologic correlation. MethodsThis retrospective study included 554 small breast masses (291 malignant and 263 benign) which were ≤ 2 cm and validated by pathology analysis between June 2016 and September 2020. All 554 patients underwent breast MRI. The clinical characteristics and MR features were analyzed. Univariate and multivariate regression analysis were performed to identify the independent risk factors of breast cancer. Two diagnostic models were constructed based on independent risk factors (model 1 included blooming sign and model 2 didn’t). ROC curve was used to evaluate the diagnostic performances of the two models. The histological changes of peritumoral tissues in all small masses were analyzed. ResultsThe blooming sign was positive in 199 cases (68.4%) of the malignant masses and 25 cases (9.5%) of the benign ones (P<0.05). Univariate and multivariate regression analysis showed that age, lesion diameter, margin, ADC value, time signal intensity curve type and blooming sign were independent risk factors for breast cancer. Odds ratio were 1.065, 4.515, 2.811, 0.013, 3.487 and 13.894, respectively. Their corresponding 95%CI were (1.034, 1.097), (2.368, 8.608), (1.954, 4.045), (0.004, 0.049), (2.087, 5.826) and (7.026, 27.477), respectively. The diagnostic performance of model 1 (blooming sign included) was better than that of model 2 (blooming sign not included; AUC: 0.938 vs 0.897, P < 0.05). Histopathological analysis showed that the blooming sign was related to peritumoral lymphocyte infiltration and vascular proliferation. ConclusionsMRI blooming sign is helpful for distinguishing breast cancer from benign masses. The correlated histopathological basis may be peritumoral lymphocyte infiltration and neovascularization.
8.Carbon Monoxide Releasing Molecule Accelerates Reendothelialization after Carotid Artery Balloon Injury in Rat.
Qing Song HU ; Yang Xin CHEN ; Qing Sheng HUANG ; Bing Qing DENG ; Shuang Lun XIE ; Jing Feng WANG ; Ru Qiong NIE
Biomedical and Environmental Sciences 2015;28(4):253-262
OBJECTIVEThis study was aimed to investigate the effects of carbon monoxide releasing molecule (CORM-2), a novel carbon monoxide carrier, on the reendothelialization of carotid artery in rat endothelial denudation model.
METHODSMale rats subjected to carotid artery balloon injury were treated with CORM-2, inactive CORM-2 (iCORM-2) or dimethyl sulfoxide (DMSO). The reendothelialization capacity was evaluated by Evans Blue dye and the immunostaining with anti-CD31 antibody. The number of circulating endothelial progenitor cells (EPCs) was detected by flow cytometry. The proliferation, migration, and adhesion of human umbilical vein endothelial cells (HUVECs) were assessed by using [3H]thymidine, Boyden chamber and human fibronectin respectively. The expressions of protein were detected by using western blot analysis.
RESULTSCORM-2 remarkably accelerated the re-endothelialization 5 d later and inhibited neointima formation 28 d later. In addition, the number of peripheral EPCs significantly increased in CORM-2-treated rats than that in iCORM-2 or DMSO-treated rats after 5 d later. In vitro experiments, CORM-2 significantly enhanced the proliferation, migration and adhesion of HUVECs. The levels of Akt, eNOS phosphorylation, and NO generation in HUVECs were also much higher in CORM-2 treated group. Blocking of PI3K/Akt/eNOS signaling pathway markedly suppressed the enhanced migration and adhesion of HUVECs induced by CORM-2.
CONCLUSIONCORM-2 could promote endothelial repair, and inhibit neointima formation after carotid artery balloon injury, which might be associated with the function changes of HUVECs regulated by PI3K/Akt/eNOS pathway.
Animals ; Carbon Monoxide ; metabolism ; pharmacology ; Carotid Artery Injuries ; drug therapy ; immunology ; metabolism ; pathology ; Carotid Artery, Common ; drug effects ; immunology ; metabolism ; pathology ; Cell Adhesion ; drug effects ; Disease Models, Animal ; Endothelial Cells ; drug effects ; immunology ; metabolism ; pathology ; Endothelium, Vascular ; drug effects ; metabolism ; pathology ; Humans ; Male ; Rats ; Rats, Sprague-Dawley