1.Clinical Research on Correlation between SOD and TXB_2/6-k-PGF_(l?) in Stroke Patients
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(11):-
Objective To research the correlation between SOD and TXB2/6-k-PGF1? and relationship with TCM syndrome in stroke patients. Methods A contrast test on blood SOD and plasma TXB2 and 6-k-PGF1? was given separately to two groups, one group was 74 cases with stroke and the control group was 36 cases in health. Results Content of b1ood SOD in stroke group reduced remarkably compared with the health group (P
4.Application of circulating tumor cells detection in non-small cell lung cancer
Hao LI ; Sheng LI ; Baijiang ZHANG
Journal of International Oncology 2015;(4):298-300
Circulating tumor cells(CTCs)are essential for establishing metastasis and recurrence in non-small cell lung cancer(NSCLC). With the development of detection technique,results from recent studies suggest that CTC level could be a supplement for TNM staging system and a prediction marker of prognosis and therapeutic efficacy,and even could be applied for risk assessment of early NSCLC. Furthermore,as a non-invasiveliquid biopsy,detection of CTC can reflect the molecular biology and genetics characteristics of the primary tumor,and subsequently assist in selecting an optimal individualized treatment.
5.Protective effects of 3-methyladenine on acute lung injury caused by multiple trauma in rats.
Jia LIU ; Gang HAO ; Long YI ; Tian-Sheng SUN
China Journal of Orthopaedics and Traumatology 2015;28(4):350-353
OBJECTIVETo investigate the role of autophagy in acute lung injury (ALI) caused by multiple trauma in rats via pretreat with 3-methyladenine (3-MA).
METHODSForty-five Sprague-Dawley male rats, with age of 4 months and body weight of 250-300 g,were randomly divided into three groups. In the sham group, the rats received sphenotresia only;in the control group, the rats were made model of femur shaft fracture combined with brain injury, and treated with physiological saline by abdominal cavity at 1 hour before making model; in the 3-MA group, the rats were made model of femur shaft fracture combined with brain injury,and treated with 3-MA of 10 mg/kg by abdominal cavity at 1 hour before making model. Histologic changes and the concentration of related inflammatory factors in the damaged lung tissue were examined at 48 h after opteration, at the same time, the effect of 3-MA on the expression of LC-3 II and Beclin-1 was examined through reverse transcriptase polymerase chain reaction technique (RT-PCR).
RESULTSCompared with sham group, LC-3 II and Beclin-1 level in control group at 48 h after operation were obviously increased (P < 0.01). Compared with control group, LC-3 II and Beclin-1 level in 3-MA group at 48 h after operation were obviously decreased (P < 0.01). Compared with sham group, the level of proinflammatory cytokines (TNF-α and IL-6) in control group obviously enhanced (P < 0.01). Compared with control group, above items in 3-MA group was obviously lower (P < 0.01). Compared with control group,the histopathological damage of lung in 3-MA group obviously reduced (P < 0.01).
CONCLUSIONAutophagy can aggravate the acute lung injury caused by fracture of shaft of femur combined with brain injuries,but 3-MA can reduce tissue damage by inhibiting the autophagy and inflammatory response.
Acute Lung Injury ; prevention & control ; Adenine ; analogs & derivatives ; therapeutic use ; Animals ; Apoptosis Regulatory Proteins ; analysis ; Beclin-1 ; Interleukin-6 ; analysis ; Lung ; chemistry ; immunology ; pathology ; Male ; Multiple Trauma ; complications ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha ; analysis
7.Data Mining of Factors Associated with Sleep Quality of Anger-out and Anger-in Population Based on FP-Tree Growing Algorithm
Ling ZHANG ; Zhi HAO ; Sheng WEI ; Peng SUN ; Mingqi QIAO
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(8):1595-1601
This article was aimed to study the factors associated with sleep quality of anger-out and anger-in population based on the frequent pattern-tree (FP-Tree) growing algorithm with data mining. The algorithm of structuring frequent model FP-tree and mining frequent itemsets were designed. The database information scanned was recorded by using FP-Tree growing algorithm through state-trees. The frequent itemsets met minimum support required was generated through reducing the search space of project sets and scanning database only one. The data mining of all factors associated with emotional diseases was actualized. The results showed that factors associated with sleep quality of anger-out and anger-in population were disturbance in respiration, cough or snoring, feeling cold, hot or nightmares. The total time for program analysis was 2 seconds. It was concluded that data mining algorithm based on FP-Tree frequent itemsets can effectively realize the useful information receiving from factors associated with emotional diseases.
8.Surgical treatment effects in cancer of the cardia and esophagogastric junction
Yumin ZHOU ; Jiong PAN ; Yuwei SHENG ; Hao LIU ; Ziping FAN
China Oncology 2006;0(08):-
0.05 ), the postoperative complication and mortality rate of PG group were 13.7% and 6.8%, of TG group was all 6%.Conclusions:Proximal and total gastrectomy treatment does not significantly influence the prognosis of patients with cardia and esophgogastric junction cancer in progressive stage.
9.The investigation and progress of the cellular and molecular biological mechanisms of Tripterygium wilfordii in treating rheumatoid arthritis.
Zhe CHEN ; Rui-Lin LI ; Sheng-Hao TU
Chinese Journal of Integrated Traditional and Western Medicine 2009;29(2):183-186
Anti-Inflammatory Agents, Non-Steroidal
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pharmacology
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therapeutic use
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Apoptosis
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drug effects
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Arthritis, Rheumatoid
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drug therapy
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immunology
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B-Lymphocytes
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drug effects
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Cytokines
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drug effects
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Drugs, Chinese Herbal
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pharmacology
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therapeutic use
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Humans
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Immunosuppressive Agents
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pharmacology
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therapeutic use
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Phytotherapy
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T-Lymphocytes
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drug effects
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Tripterygium
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chemistry
10.Influence of rhIL and rhTPO on the number and quality of platelet and coagulability of whole blood in monkeys.
Xiao-Lan LIU ; Ling-Sheng SUN ; Jing HAO
Chinese Journal of Applied Physiology 2002;18(3):282-305
Animals
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Blood Coagulation
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drug effects
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Blood Platelets
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drug effects
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Female
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Haplorhini
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Humans
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Interleukin-11
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pharmacology
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Male
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Platelet Count
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Thrombopoietin
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pharmacology