1.Temperature Measurement with Bluetooth under Android Platform.
Shuai WANG ; Hao SHEN ; Changze LUO
Chinese Journal of Medical Instrumentation 2015;39(3):181-196
To realize the real-time transmission of temperature data and display using the platform of intelligent mobile phone and bluetooth. Application of Arduino Uno R3 in temperature data acquisition of digital temperature sensor DS18B20 acquisition, through the HC-05 bluetooth transmits the data to the intelligent smart phone Android system, realizes transmission of temperature data. Using Java language to write applications program under Android development environment, can achieve real-time temperature data display, storage and drawing temperature fluctuations drawn graphics. Temperature sensor is experimentally tested to meet the body temperature measurement precision and accuracy. This paper can provide a reference for other smart phone mobile medical product development.
Body Temperature
;
Cell Phone
;
Humans
;
Programming Languages
;
Software
;
Wireless Technology
2.Evaluation system for the Wechat influence of a hospital and its applications
Shihua SHEN ; Chen WANG ; Hao ZHANG
Chinese Journal of Hospital Administration 2015;31(6):467-469
The evaluation indexes are selected from the aspects of hospital behavior and user behavior based on the relevant theories on influence and the transmission characteristics of Wechat,with the data so acquired processed with the principal component analysis.In the end,the expression of evaluation was applied to the evaluation and analysis of the influence of the hospital Wechat.
3.Diagnosis and treatment of bronchiectasis in children
Baoping XU ; Hao WANG ; Kunling SHEN
Chinese Journal of Applied Clinical Pediatrics 2017;32(4):245-249
Bronchiectasis is a kind of chronic lung disease which threatens the health of children in China.It can affect the lung function,life quality and development of the patients.There are varied causes of bronchiectasis,and some of the causes have the special intervention.So the etiology diagnosis of bronchiectasis is important.The aims of the treatment of bronchiectasis is removing the causes,releasing the symptoms,preventing the acute exacerbation,sustaining the lung function and life quality.It needs a long tern combine therapy.
4.Changes in heart rate variability in patients after coronary artery bypass graft
Zhengping WANG ; Hao SHEN ; Suning ZUO
Chinese Journal of Anesthesiology 1995;0(12):-
Objective To investigate the significance of the changes in heart rate variability (HRV) in patients undergoing coronary artery bypass graft procedure Methods Thirty six patients scheduled for elective coronary artery bypass were studied HRV was monitored by HXD I monitoring system one day prior to surgery (as baseline values), before anesthesia, at the end of surgery and on the 3rd day and 6th day after surgery Results The baseline logical values for total power(TP), low frequency (LF), high frequency (HF), LF/HF ratio were 3 07?0 35, 2 38?0 47, 2 37?0 54 and 1 34?0 93 respectively There were no significant changes in all these parameters before anesthesia as compared to baseline values LF,HF and TP decreased significantly on the 3rd day after surgery as compared with baseline values, and were kept at the level on the 6th postoperative day Conclusions The decrease in HRV power can last over 6 days after coronary bypass graft surgery, signifying reduced autonomous regulation of heart in the early postoperative days
5.Clinical application of MR susceptibility weighted imaging in intracranial hemorrhage
Baozhong SHEN ; Dan WANG ; Xilin SUN ; Hao SHEN ; Fang LIU
Chinese Journal of Radiology 2009;43(2):156-160
Objective To assess the value of susceptibility weighted imaging(SWI) in the diagnosis of intracranial hemorrhage. Methods Forty patients with intracranial hemorrhage underwent MRI scanning (GE Signa HDe 1.5 T), which included T2WI, T1WI, T2 * WI and SWI. Of them, DWI was conducted in 37 cases and enhanced MRI was conducted in 10 cases additionally. After post processing on the workstation, both magnitude and phase images of SWI were acquired for further analysis. The images of all sequences were scored from 1 to 3, according to their ability of depicting the lesions. Statistical analysis was conducted to compare the scores among these sequences. Results On SWI, the scores in detecting the lesions, their margin and adjacent veins were 2. 8, 2. 8, and 2. 8 respectively. The scores of those were 1.8, 1.7,and 0.0 on T1WI, 2.3, 2.0 and 0.0 on T2WI, 2.0, 2.1 and 0.2 on T2* WI, respectively. There was statistical difference between the scores on SWI and those on T1WI, T2 WI and T2 * WI ( P < 0. 01 ). The numbers of micro hemorrhagic lesions that could be observed on SWI, T1WI, T2WI, DWI and T2 *WI were 402, 55, 61, 84 and 188 respectively. There was statistical difference in showing micro hemorrhagic lesions between SWI and T1WI, T2WI, DWI, T2 * WI (P < 0. 01 ). Conclusion SWI is sensitive to visualize the hemorrhagic region, and has predominant advantage over conventional MR sequences including T2 * WI in detecting intracranial hemorrhage, especially cerebral microbleeding. According to the features of the paramagnetic and diamagnetic lesions, radiologists can differentiate hemorrhage and calcification with phase images.
6.Effects of Chinese herbal medicine Jinqi Jiangtang Tablet on serum matrix metalloproteinase-9 level and its expression in peripheral blood monocytes of rats with diabetes mellitus.
Hao WANG ; Lin SHEN ; Zhiguo WANG ; Yi CAO
Journal of Integrative Medicine 2011;9(4):442-446
Objective: To observe the effects of Jinqi Jiangtang Tablet, a compound Chinese herbal medicine, on serum matrix metalloproteinase-9 (MMP-9) level and MMP-9 expression in peripheral blood monocytes of rats with streptozocin-induced diabetes. Methods: Thirty Wistar rats were randomly divided into 3 groups: control group, untreated group and Jinqi Jiangtang Tablet group. Diabetes in rats was induced by a single intraperitoneal injection of streptozocin (70mg/kg body weight). After model building, rats in the Jinqi Jiangtang Tablet group were administered with Jinqi Jiangtang tablets at a dose of 0.8 g/(kg·d) for 6 weeks and rats in the control group and the untreated group were treated with normal saline. After treatment, level of fasting serum glucose was detected by hexokinas method; serum MMP-9 level was tested by enzyme-linked immunosorbent assay; MMP-9 expression in peripheral blood monocytes was measured by reverse transcription-polymerase chain reaction and Western blot method. Results: After treatment, fasting serum glucose level in the Jinqi Jiangtang Tablet group was less than that in the untreated group (P<0.05). After modeling, the serum MMP-9 level of rats in the untreated group was (9.11±3.55) μg/L and that in Jinqi Jiangtang Tablet group was (8.97±3.07) μg/L, which were higher than that in the control group ((4.39±1.44) μg/L) (P<0.01). After gavage, the level of serum MMP-9 was lower in Jinqi Jiangtang Tablet group than in the untreated group (P<0.05). The expression of MMP-9 in peripheral blood monocytes in the untreated group was higher than that in the control group (P<0.05). The MMP-9 expression in peripheral blood monocytes of rats with diabetes was down-regulated by Jinqi Jiangtang Tablet (P<0.05). Conclusion: Jinqi Jiangtang Tablet can decrease the level of serum MMP-9 and down-regulate the MMP-9 expression in peripheral blood monocytes at both mRNA and protein levels in rats with diabetes.
7.The research of effect of CQI in the physical diagnosis
Jianwen WANG ; Shourong SHEN ; Weilian PENG ; Hao ZHANG ; Chenghong WANG
Chinese Journal of Medical Education Research 2011;10(9):1050-1052
ObjectiveTo explore the effect of CQI on the teaching of physical diagnostics.MethodsThe theory and practice of CQI are discussed in accordance with specific conditions of the teaching of physical diagnostics.ResultsThe level of the teaching of physical diagnostics can be raised by applying CQI.ConclusionThere will be broad prospects in the application of CQI to quality teaching of physical diagnostics.
8.Effect of silencing human RRM 2 by specific siRNA on the biological behavior of human osteosarcoma cell
Teng LIAO ; Zhong WANG ; Yiping WANG ; Wentao HUANG ; Hao SHEN
Chinese Journal of Primary Medicine and Pharmacy 2013;20(17):2566-2569
Objective To investigate the effect of small interference RNA(siRNA) targeting RRM2 on the biological behavior of human osteosarcoma cell line Saos-2 and the molecular mechanisms.Methods RRM2 expression was knocked down in human osteosarcama cell line Saos-2 by RRM2 siRNA.The expression of RRM2 mRNA and protein was determined in human osteosarcoma cell line Saos-2 and human osteoblast-like cell line hFOB1.19 by real time-PCR and Western blot.The cell proliferation was detected by CCK-8.The migration was observed by using transwell system.The apoptotic rate was observed by ELISA.The expression of CyclinD1 and Bcl-2 proteins were detected by Western blot.Results The expression of RRM2 mRNA and protein was higher in Saos-2 than in hFOB1.19.siRRM2 could down-regulate the expression of RRM2 in Saos-2 cells in a time-and concentration-dependent manner.CCK-8 assay showed that si-RRM2 could inhibit the proliferation ability of Saos-2 cells in a time-and concentrationdependent manner,but had no effect on the proliferation of hFOB1.19 cells.Transwell assay indicated that si-RRM2 could inhibit the migration of Saos-2 cells.si-RRM2 combined with adriamycin could increase the apoptosis of Saos-2 cells.Western blot showed that the expression of Cyclin D1 and Bcl-2 were decreased by silencing RRM2.Condusion RRM2 overexpression maybe associate with the osteosarcoma cells proliferation and migration and suppression of its function is a potential therapeutic strategy in osteosarcoma.
9.Clinicopathological features of renal cell carcinoma : a primary study of 705 cases
Gongwei WANG ; Ying WANG ; Yunxin CHEN ; Hao HU ; Danhua SHEN
Chinese Journal of Urology 2014;35(4):254-257
Objective To investigate the clinicopathological features of renal cell carcinoma (RCC).Methods From December 1956 to August 2012,the clinicopathological features of RCC were studied in 705 cases and related literatures were reviewed.Results The diameter of RCC ranged from 0.6 to 18.0 cm,which the average size was 4.6 cm.The proportions of the clear cell,papillary,multilocular clear cell,chromophobe and unclassified histologic subtype were 88.9% (627/705),4.1% (29/705),3.3% (23/705),1.3% (9/705) and 2.4% (17/705),respectively.According to the Fuhrman grading system,the proportions of grade 1,2,3,4 were 19.0% (116/612),58.3% (357/612),18.1% (111/612)and 4.6% (28/612),respectively.The rates of invasion into the renal pelvis,perirenal fat and vascular were 10.9% (66/603),10.6% (64/603) and 4.8% (29/603),respectively.Of 705 cases,464 (76.6%)cases were in T1,65 (10.7%) cases in T2,73 (12.0%) cases in T3,and 4 (0.7%) cases in T4.As to the lymph node and distant metastasis,the rate was 2.8% (17/606) and 3.5% (21/606).The percentages of stage Ⅰ,Ⅱ,Ⅲ and Ⅳ RCC were 74.3% (450/606),9.9% (60/606),11.7% (71/606) and 4.1%(25/606),respectively.The 3-,5-,10-and 15-year disease-specific survival rate for RCC was 92.8%,86.9%,76.8% and 55.5%,respectively.To those patients with clear cell RCC,the disease-specific survival at the same time point was 92.8%,88.1%,77.4% and 55.4%,respectively.Multivariate analysis showed that the stage was the only independent prognostic factor for RCC.Conclusions Tumor stage of RCC is the independent prognostic factor for disease-specific survival.The evaluation of renal sinus invasion and lymph node should be noted in the diagnosis of RCC.
10.The Effect of Salvia Miltiorrhiza on Gentamicin Ototoxicity-Induced Activity of Nitric Oxide Synthase in Cochlea of Guinea Pig
Aimei WANG ; Hao TANG ; Jing SHEN ; Xiubin FANG ; Tiemin WANG
Journal of China Medical University 2001;30(2):85-87
Objective: Our purpose was to explore the protective role of Salvia Miltiorrhiza (SM) on gentamicin (GM) ototoxicity. Methods: We used NADPH-diaphorase in histochemical staining and image quantitative analysis technique, combined with auditory brainstem response (ABR) measurement to investigate the change of nitric oxide synthase (NOS) activity in cochlea of guinea pig after the injection of GM and SM. Results: Gebtamicin and SM significantly reduced NOS activity in cochlear and the threshold of ABR compared with GM alone (P<0.01); and the threshold of ABR was in high correlation with NOS activity (rGM= -0.8236 ~ -0.8662; rSM+GM= -0.8628 ~ -0.9172, P<0.01). Conclusion: Salvia Miltiorrhiza can reduce NOS activity in cochlea, alleviate GM ototoxicity, and ameliorate hearing function.