In vitro and in vivo animal model experiments have found that salidroside has protective effect for various causes induced injuries in various neurons and brain tissue.Its mechanisms of neuroprotection are multiple:(1)Protecting neurons from apoptotic injury by resisting oxidative stress,preventing intracellular Ca2 + overload,inhibiting caspase-3 activation,and attenuating hypoxia-induced abnormal metabolism of amyloid precursor protein;(2)promoting directional differentiation of stem cells into neurons and inducing neuronal regeneration;(3)promoting erythropoietin stimulating erythroblasts to be differentiated into erythrocytes and decreasing cerebrovascular resistance,and improving cerebral hypoxia-ischemia.Salidroside is expected to be used in the prevention and treatment of cerebral ischemic and neurodegenerative diseases,such as cerebral infarction,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and diabetic encephalopathy.

OBJECTIVETo study the impacts of electroacupuncture (EA) on memory impairment after cerebral infarction through the observation of hydrogen proton magnetic resonance spectroscopy (1H-MRS) of brain tissue metabolites in the patients of cerebral infarction.

METHODSSixty cases of memory impairment after cerebral infarction were randomized into an observation group and a control group, 30 cases in each one. The conventional rehabilitation training and medication were applied to all the patients. In the observation group, beside the basic treatment, EA was applied to bilateral Ezhongxian (MS 1), Dingzhongxian (MS 5), Dingniehouxiexian (MS 7), Hegu (LI 4), Taichong (LR 3), Zusanli (ST 36), Taixi (KI 3), Xuanzhong (GB 39) and Fengchi (GB 20). The treatment was given once a day, 5 times a week, for 8 weeks. The clinical memory scale was used for the score evaluation before and after treatment in all the patients. The magnetic resonance image (MRI) and 1H-MRS scanning were applied to the head. The ratio of N-acetyl aspartate (NAA) and creatine (Cr) and the ratio of choline (Cho) and Cr were determined in the foci of cerebral infarction.

RESULTSEight weeks later, the scores of clinical memory scale were all increased after treatment as compared with those before treatment in the two group (all P<0. 01). The ratio of NAA and Cr was increased as compared with that before treatment (P<0. 05); the ratio of Cho and Cr was reduced as compared with that before treatment (P<0. 05). The changes in the observation group were more obvious than those in the control group (all P<0. 05).

CONCLUSIONOn the basis of the conventional medication and rehabilitation training, EA improves the metabolism of brain tissue and memory function of the patients. The efficacy of this therapy is better than that of medication combined with rehabilitation training.

Adult ; Aged ; Aged, 80 and over ; Brain ; diagnostic imaging ; Cerebral Infarction ; complications ; diagnostic imaging ; Electroacupuncture ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Memory ; Memory Disorders ; etiology ; psychology ; therapy ; Middle Aged ; Radiography

Objective To determine the optimal suetioning negative pressure based on various sputum viscosity in brain-in-jured patients with tracheotomy. Methods Forty-three traumatic brain-injured patients with traeheotomy were recruited in the study. The negative pressure was determined based on the grade of sputum viscosity. Grade Ⅰ sputum was suetioned with the negative pressure of 13.3kPa,16.0kPa,20.0kPa and 24.0kPa, while Grade Ⅱ sputum with 20.0kPa,24.0kPa,26.TkPa and 29.3kPa,and Grade Ⅲ sputum with 26.7kPa,29.3kPa, 33.3kPa and 37.2kPa. The oxygen saturation(SpO2)was mort-itored before and lmin,3min,5min after endotracheal suctioning. At the same time,the suctioning time and tissue trauma were recorded. The data were analyzed by repeated measures analysis of variance with SPSS 13.0 software. Results The results showed that the optimal negative pressure was 13.3-16.0kPa for grade Ⅰ sputum,24.0-26.7kPa for grade Ⅱ sputum and 33.3kPa for grade Ⅲ sputum,which could ensure the minimum decrease of SpO2 and control the suctioning time within 25s or 30s respectively. Conclusion For traumatic brain-injured patients,varions negative pressure should be selected based on the sputum viscosity by the clinical nurses when suctioning is performed,in order to avoid hypoxemia and tissue trauma caused by suctioning.

Under the high pressure of employment, traditional teaching method that is based on inculcating the knowledge to students does not adjust current condition any more. So, we start to looking for a new, more suitable way of teaching.--Project Based-on Learning, and have analyzed the advantages in health information technology teaching by construction doctrine in combination with the concept and principle in wedlock construction. At the same time we introduce project Based-on Learning in concrete application to find a way to put the theory into practice.

Objective To investigate atorvastatin administration on osteopontin and cardiac function of patients with chronic heart failure(CHF).Methods Sixty CHF patients were randomly divided into control (30 cases) and atorvastatin groups (30 cases).Patients in control group were given regular treatment including conventional oxygen inhalation,digitalis,angiotensin converting enzyme inhibitors,β blockers,diuretics,vasodilator therapy.Patients in treatment group were given atorvastatin at dose of 20 mg/d for 2 months plus regular treatment.The NHYA cardiac function,echocardiography determination of left ventricular ejection fraction(LVEF) were recorded.The levels of plasma osteopontin,plasma N-terminal brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) were measured.Results The levels of plasma osteopontin,NT-proBNP and CRP in atorvastatin group were (1 062.68 ± 130.63) ng/L,(609.00 ±62.39) ng/L and ((5.84 ± 0.70) mg/L respectively,lower than those of control group ((1609.94 ± 201.87) ng/L,(922.33 ± 108.68) ng/L,(8.90 ± 0.86) mg/L),and the differences were statistically significant (Z =-1.981,t =2.766,Z =-2.092,P ＜0.05).LVEF in atorvastatin group was (58.7 ± 1.2)％,higher than that in control group ((52.8 ± 1.6) ％ ; P ＜ 0.05).Conclusion Atorvastatin treatment can decrease plasma osteopontin density,alleviate the inflammatory response and inhibit cardiac remodeling in patients with heart failure,which was good for recovery of heart failure.

The etiology of nasopharyngeal carcinoma is still not very clear.Epigenetics is proved to play an important role in the occurrence and development of nasopharyngeal carcinoma (NPC).Detection of epigenetics can serve as molecular index of NPC,and it is advantageous to the prognosis and disease of NPC.Different intervention measures in the epigenetics can be used as a new treatment of NPC,as well as the development of new NPC radiotherapy sensitization agent and new drugs.Study of epigenetics changes in nasopharyngeal carcinoma provides a new idea for the diagnosis and treatment in NPC and so on.

Breast cancer is the most common disease in women worldwide, which not only threatened the women’s survival time, but also inlfuenced their quality of life as well. Within this challenge, it’s important to optimize the current multidisciplinary treatment stratagem for breast cancer. Radiotherapy is one of the most important treatment modality for patients with breast cancer, with the trend to shrink the irradiated volume and shorten the total fraction times in recent years. Intraoperative radiation therapy (IORT) as a fast and convenient procedure has the ability to deliver a high, single-fraction radiation dose to tumor beds with minimal exposure of surrounding tissues (lung, heart, etc.), which could be displaced or shielded right after the tumor removal during the surgical procedure. Right now, IORT has been either integrated as a boost technique in multimodal approaches using postoperative EBRT in the treatment of early breast cancer patients undergoing breast conservation surgery or used as a single dose accelerated partial breast irradiation technique for these patients. This review discussed the rationale of IORT, the beneifts and limitations of IORT, the indication and the clinical results of this procedure, including treatment related side-effects as well in order to provide the preliminary evidence based approach for early breast cancer patients.

Objective To boost the transformation and sustainable development of medical scientific achievements. Methods Investigations in the form of questionnaires were made and descriptive statistics was conducted. Results Eighty to ninety percent of the achievements awards were allocated to the research project teams or the principal prize winners. Most of the achievements transformation awards were retained by the units while only ten to twenty percent went to the principal awardees and only two to three percent went to the management and intermediary personnel. There also existed such problems as weak awareness of achievements transformation and lack of scientificalness in the achievements review and evaluation system, assessment system and assessment indexes. Conclusion The awareness of scientific achievements transformation should be enhanced and the transformation should be implemented on a market oriented and commercial basis; the scientificalness of achievements review and evaluation should be improved; more awards should be given and more social fundraising activities should be conducted; and scientific research management should be included among the factors to be considered when allocating money awards.

During the resistance to SARS, medical staff's medical ethics accumulation reflects generously. The test of SARS has promoted the medical staff's social responsibility consciousness, strengthened the coordination between each other and sublimed the morals in the whole society. Therefore, the sufficient realization of the accumulation of medical ethics depends on the enhancement of hygiene industry input;the display of the accumulation of medical ethics depends on the positive propaganda and encouragement to medical staff; the expansion of the medical ethics epitaxy depends on the fully excavation and utilization of the accumulation of medical ethics.

Oxypeucedanin (OP) 300 and 600mg/kg ig inhibited the increased permeability of intraperitoneal blood capillary induced by ip 0. 7% acetic acid in mice, xylene-induced swelling of mouse ear, retarded gastrointestinal propellant rate of charcoal ink in normal mice,and reduced the incidence and frequency of purging induced by castor oil or senna in mice. These actions were enhanced in a dose-dependent manner. It is suggested that the antidiarrheal effect of OP is relative to its restriction against inflamation and gastrointestinal propellant function.