Objective To observe the efficacy and safety of Ginkgo biloba extract combined with Nimodipine on patients with acute cerebral infarction.Methods 106 cases of acute cerebral infarction were randomly divided into two groups(control group and treatment group),the control group was given Nimodipine on the basis of regular treatment,and the treatment group was given Ginkgo biloba extract combined with Nimodipine on the basis of regular treatment.Results The total effective rate of treatment group was higher than that of the control group (x2 =3.62,P ＜0.05),improvement of neurological deficit was better than that of the control group (t =2.57,5.32,all P ＜ 0.05),Plasma TC and TG levels were significantly lower than that of the control group(t =4.23,6.43,all P ＜ 0.05).During treatment,patients had no serious adverse reactions.Conclusion Ginkgo biloba extract and Nimodipine have synergistic effects,the two combined treatment of acute cerebral infarction have significantly effects,which is safe and reliable.

Objective: To study the anti-complementary anthraquinones from Polygonum cuspidatum and their action targets. Methods: The anti-complementary activity-directed isolation was carried out with the hemolysis test as guide. All isolates were evaluated for their in vitro anti-complementary activities. The action targets of the main bioactive constituents were also examined using complement-depleted sera. Results: Ten anthraquinones and three other compounds were isolated from the EtOAc fraction of P. cuspidatum extract, including physcion (1), chrysophanol (2), questin (3), emodin-8-O-β-D-glucoside (4), emodin (5), rhein (6), fallacinol (7), citreorosein (8), xanthorin (9), isorhodoptilometrin (10), 2, 5-dimethyl-7-hydroxychromone (11), 7-hydroxy-4-methoxy-5-methylcoumarin (12), and 5, 7-dihydroxy-1-isobenzofuranone (13). Compounds 9 and 10 were isolated from the the plants of Polygonaceae for the first time, and compound 9 was the alizarin-type anthraquinone first obtained from P. cuspidatum. Compounds 3-9 showed the anti-complementary activity in different degrees, and compound 7 exhibited the most significant activity against the classical and alternative pathway [CH50 = (6 ± 2) μg/mL, AP50 = (50 ± 5) μg/mL]. The study on the preliminary mechanism revealed that compound 4 interacted with C1q, C2, and C9 in complement activation cascade, while compound 7 acted on C1q, C2, C4, and C9. Conclusion: The anthraquinones are main anti-complementary constituents in P. cuspidatum; and fallacinol (7) is a potential complement inhibitor with strong activity and definite targets, which should be further studied in future.

Lung cancer is the most common cancer and the leading cause of cancer-related deaths in the world. More than 50 % of advanced NSCLC are diagnosed in patients older than age 65 years. Aging is inextricably associated with decreases in marrow reserve, drug clearance, and lean body mass. Elderly cancer patients often present with medical and physiologic challenges that make the selection of their optimal treatment daunting. This article reviews the progress in diagnosis and treatment of lung cancer in the elderly in recent years.

Hilar cholangiocarcinoma (HCCA) or Klatskin tumor is a scirrhous adenocarcinoma that arises from the conjunction of bile duct and hepatic ducts.Hepatic magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP) are important methods for the diagnosis of HCCA.In this article,the clinical data of 42 patients in the Changhai Hospital and 18 patients in the Eastern Hepatobiliary Surgery Hospital who received MRI and MRCP examination from October 2010 to October 2012 were retrospectively analyzed.According to the pathological features,HCCA could be divided into mass-forming type,infiltrating type and intraductal type.Based on the results of imaging examination and intra-and postoperative pathological examination,Bismuth-Corlette types were decided pre-and postoperatively.The coincidence rate of pre-and postoperative Bismuth-Corlette types was 89.7％ (35/39).Infiltration of liver parenchyma was both detected pre-and postoperatively in 19 patients (16 patients were detected by MRI preoperatively),and the sensitivity of MRI was 84.2％ ; vascular invasion was both detected pre-and postoperatively in 10 patients (12 patients were detected by MRI preoperatively),and the sensitivity of MRI was 83.3％ ; hilar and retroperitoneal lymph node metastasis was both detected pre-and postoperatively in 6 patients (4 patients were detected by MRI preoperatively),and the sensitivity of MRI was 66.7％.Combined application of different sequences and techniques of MRI is helpful in the diagnosis,staging and treatment of HCCA.

Objective To research on study attitudes of military medical university undergraduates. Methods The study attitudes of all the undergraduates were investigated and compared in different sorts by using homemade questionnaires. Results The general study attitudes of military medical university undergraduates were good. The undergraduates of different grades had not different study attitudes, neither did the undergraduates of different ages. The undergraduates of different sorts had different attitudes, so did the undergraduates of different genders and different specialties. Concretely, the undergraduates not recruited by Army, the men undergraduates, the undergraduates of long academic-year program and five-year military medico have better study attitudes. Conclusion The general study attitudes of military medical university undergraduates were good but there is still some space to boost. All sorts of steps should be taken to correct their study attitudes and advance their study effects.

Objective To observe the efficacy and prognosis of aconite-cake-partitioned moxibustion plus acupuncture in treating peptic ulcer.Method Thirty-four patients in the treatment group were intervened by aconite-cake-partitioned moxibustion plus acupuncture, while thirty-three patients in the control group were by Omeprazole Enteric-coated Capsules. The clinical efficacy, the effect on ulcer under gastroscope and Hp, and the therapeutic efficacy 12 months after the intervention were evaluated.Result The total effective rate was 91.2% in the treatment group versus 72.7% in the control group, and the difference was statistically significant (P<0.05). For ulcer by gastroscopy, the total effective rate was 85.3% in the treatment group versus 69.7% in the control group, and the difference was statistically significant (P<0.05). After intervention, the Hp level didn’t show significant change (P>0.05). The relapse rate of the control group was higher than that of the treatment group 12 months after the intervention.Conclusion Aconite-cake-partitioned moxibustion plus acupuncture can produce a higher efficacy than Western medication in treating peptic ulcer.

To observe the efficacy of fumigation with Fumigant I formula, a compound traditional Chinese herbal medicine, in treating adjuvant arthritis (AA) in rats and to explore its anti-inflammation mechanism.

Objective To establish the quality specification of Zanglian Pill. Methods Rhizoma coptidia,fructus sophorae and flos sophorae were identified by TLC. Radix scuteUariae was determined by HPLC. Intersit Cas column was used with the mobile phase of 2 % acetic acid-methanol(45:55 ), at the detection wavelength of 280nm.Results The calibration curve was linear in the range of 0. 0434～4.34 μg. The average recovery rate of baiealin was 99.2 % with RSD of 1.10 %. The TLC spots developed were fairly clear, and the blank test showed no interference. Conclusion The method developed is simple and accurate with a good reproducibility,and the method can be used for the quality control of Zanglian Pill.

OBJECTIVE:To provide the reference for the Chinese government to establish medication policy in paediatrics.METHODS:The paediatric medication strategy set up by British Drug and Health Product Administration Bureau was introduced,and the current situation and problems in paediatric medication were analyzed.RESULTS & CONCLUSION:China should learn from British experience,and establish our own medication strategy in paediatrics as soon as possible.

Bone is the most common site for metastasis from prostate cancer, and bone metastases also is one of the main causes for the death of the patients with prostate cancer. Since the patients with bone metastases from prostate cancer still have relatively long survival periods after treatmemt, how to properly choose the treatment option for the metastatic patients is imperative in terms of improvements in both quality of life and life expectation. This paper summary pathophysiology, risk evaluation clinical assessment and the current status of the treatment options of prostate cancer with bone metastases, it also lays out the background for the individualized treatment plan that still needs to be further investigated.