Objective To observe the efficacy and safety of Ginkgo biloba extract combined with Nimodipine on patients with acute cerebral infarction.Methods 106 cases of acute cerebral infarction were randomly divided into two groups(control group and treatment group),the control group was given Nimodipine on the basis of regular treatment,and the treatment group was given Ginkgo biloba extract combined with Nimodipine on the basis of regular treatment.Results The total effective rate of treatment group was higher than that of the control group (x2 =3.62,P ＜0.05),improvement of neurological deficit was better than that of the control group (t =2.57,5.32,all P ＜ 0.05),Plasma TC and TG levels were significantly lower than that of the control group(t =4.23,6.43,all P ＜ 0.05).During treatment,patients had no serious adverse reactions.Conclusion Ginkgo biloba extract and Nimodipine have synergistic effects,the two combined treatment of acute cerebral infarction have significantly effects,which is safe and reliable.

Objective: To study the anti-complementary anthraquinones from Polygonum cuspidatum and their action targets. Methods: The anti-complementary activity-directed isolation was carried out with the hemolysis test as guide. All isolates were evaluated for their in vitro anti-complementary activities. The action targets of the main bioactive constituents were also examined using complement-depleted sera. Results: Ten anthraquinones and three other compounds were isolated from the EtOAc fraction of P. cuspidatum extract, including physcion (1), chrysophanol (2), questin (3), emodin-8-O-β-D-glucoside (4), emodin (5), rhein (6), fallacinol (7), citreorosein (8), xanthorin (9), isorhodoptilometrin (10), 2, 5-dimethyl-7-hydroxychromone (11), 7-hydroxy-4-methoxy-5-methylcoumarin (12), and 5, 7-dihydroxy-1-isobenzofuranone (13). Compounds 9 and 10 were isolated from the the plants of Polygonaceae for the first time, and compound 9 was the alizarin-type anthraquinone first obtained from P. cuspidatum. Compounds 3-9 showed the anti-complementary activity in different degrees, and compound 7 exhibited the most significant activity against the classical and alternative pathway [CH50 = (6 ± 2) μg/mL, AP50 = (50 ± 5) μg/mL]. The study on the preliminary mechanism revealed that compound 4 interacted with C1q, C2, and C9 in complement activation cascade, while compound 7 acted on C1q, C2, C4, and C9. Conclusion: The anthraquinones are main anti-complementary constituents in P. cuspidatum; and fallacinol (7) is a potential complement inhibitor with strong activity and definite targets, which should be further studied in future.

Bone is the most common site for metastasis from prostate cancer, and bone metastases also is one of the main causes for the death of the patients with prostate cancer. Since the patients with bone metastases from prostate cancer still have relatively long survival periods after treatmemt, how to properly choose the treatment option for the metastatic patients is imperative in terms of improvements in both quality of life and life expectation. This paper summary pathophysiology, risk evaluation clinical assessment and the current status of the treatment options of prostate cancer with bone metastases, it also lays out the background for the individualized treatment plan that still needs to be further investigated.

Objective To observe the therapeutic efficacy of acupuncture plus moxibustion in treating chemoradiotherapy-induced leukopenia in patients with malignant tumors.Method A total of 120 patients with malignant tumors who presentedleukopenia during receiving chemoradiotherapy were randomized into two groups. Sixty cases in the treatment group were intervened by acupuncture plus moxibustion; sixty cases in the control group were intervened by oral administration of Batilol tablets and Leucogen tablets.The peripheral white blood cell (WBC) count in the two groups was detected on treatment day 3, 7, 14, 21, and 28.The clinical efficacies of the two groups were compared.ResultThe WBC started toincreaseafter 1-week treatment in thetreatment group (P<0.05) and the increase was statistically significant after 2-week treatment (P<0.01); in the control group, the WBC started to increase after 2-week treatment (P<0.05)and the increase was statistically significant after 3-week treatment (P<0.01); the effect of increasing WBC was more significant in the treatment group compared to the control group (P<0.05,P<0.01).The total effective rate was 90.0% in the treatment group versus 53.3% in the control group, and the between-group difference was statistically significant (P<0.01).Conclusion Acupuncture plus moxibustion can produce a significant efficacy in treating leukopenia induced by chemoradiotherapy.

OBJECTIVE:To provide the reference for the Chinese government to establish medication policy in paediatrics.METHODS:The paediatric medication strategy set up by British Drug and Health Product Administration Bureau was introduced,and the current situation and problems in paediatric medication were analyzed.RESULTS & CONCLUSION:China should learn from British experience,and establish our own medication strategy in paediatrics as soon as possible.

TNF in sera from BALB/c mice treated with sepia was detected by L929 cell killing assay. Sera of the mice treated with saline were used as control. Results showed a significant TNF -inducing activity of sepia in animals. And the induced sera were also cytotoxic to human cancer cells,such as GM803 and Y99.

Protozoal infection is one of the most important opportunistic infections among patients with acquired immune deficiency syndrome(AIDS). In order to enhance the knowledge of protozoal infections in AIDS, the current status of diagnosis and treatment of toxoplasmic encephalitis, cryptosporidiosis, microsporidiosis and isosporiasis was reviewed in this paper.

Objective To establish the quality specification of Zanglian Pill. Methods Rhizoma coptidia,fructus sophorae and flos sophorae were identified by TLC. Radix scuteUariae was determined by HPLC. Intersit Cas column was used with the mobile phase of 2 % acetic acid-methanol(45:55 ), at the detection wavelength of 280nm.Results The calibration curve was linear in the range of 0. 0434～4.34 μg. The average recovery rate of baiealin was 99.2 % with RSD of 1.10 %. The TLC spots developed were fairly clear, and the blank test showed no interference. Conclusion The method developed is simple and accurate with a good reproducibility,and the method can be used for the quality control of Zanglian Pill.

Objective To observe the therapeutic effect of herbal fumigation and steaming for rheumatoid arthritis(RA) and to explore its anti-inflammation mechanism.Methods Twenty-two RA patients were randomized into two groups: group A(N=10) received meloxican and methotrexate,and group B(N=12) received herbal fumigation and steaming of Xunzheng Prescription(mainly composed of Rhizoma et Radix Notopterygii,Radix Angelicae Pubescentis,Radix Saposhnikoviae,Ramulus Cinnamomi,Herba Asari,Rhizoma Chuanxiong,Caulis Piperis Kadsurae,Radix Cynanchi Paniculati,Rhizoma Curcumae Longae,Lignum Sappan,Borneolum Syntheticum) additionally.The treatment lasted 20 days.The changes of joint symptoms and signs,erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) were observed before and after treatment.Serum tumornecrosis factor ?(TNF-?) and intercellular adhesion molecule 1(ICAM-1) contents were detected by enzymelinked immunoassay.Results Compared with group A,joint pain and tenderness index as well as morning stiffness time were improved in group B (P

Objective To study traditional Chinese herb fumigation and steaming in treating AA model rats and the change of IL-1? in serum and joint, and explore its mechanism. Method Fifty Wistar rats were randomly divided into normal group, model group, aqua group, high dose group, low dose group. Except normal group and the right foot of rats were injected CFA 0.1 mL to make AA model. Aqua group, high dose group and low dose group received steam treatment for 10 days. In the 21st day, the content of IL-1? in serum and the expression level in joint were detected. Results Traditional Chinese herb fumigation and steaming group had notable reduction the IL-1? content in serum and strong positive expression of IL-1? in joint than model group. Conclusion Traditional Chinese herb fumigation and steaming can down-regulate the level of IL-1? in serum and restrain IL-1? expression in joint.