AIM: To study the pharmadynamics in association with the clinical effect of Fufangdaqinye Mixture. METHODS: The method of this study included anti fever, anti inflammatory and anti bacteria experiment. RESULTS: Fufangdaqinye Mixture was quite effective for the fever induced by endotoxin in rabbit, and preserved those mice from death caused by abdominal injection of staphylococcus aureus and itemophilus influenze and had a effect against staphylococcus aures, hemophilus influenze, peumococcus and streptococcus A and B. Fufangdaqinye Mixture could significantly inhibit the foot swelling and significantly inhibit the increased penetrability of abdominal capillary vessel induced. CONCLUSION: Fufangdaqinye Mixture has a curative effect of anti fever, anti bacteria and anti inflammation.