Objective The techniques and early effect of perendoscopic intrasphincteric injection of botulinum toxin (BTXA) for achalasia was introduced and evaluated. Methods 13 patients with achalasia were enrolled in the study.Symptom scoring ( modified ) and esophagography ( measuring cardiac opening,height and width of contrast media retention in 5 minutes ) were performed before and one week after treatment.1 ml of BTXA (20 u) was injected endoscopically at a point of every quadrant (4 points) situated 0.5 cm above the dentate line into the lower esophageal sphincter. Results The symptoms improved remarkably the next day as chest pain,frequency and seriousness of dysphagia and regurgitation declined significantly (P

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