Objective To investigate the clinical effect of transthoracic and mammary minimally invasive endoscopic surgery in the treatment of papillary thyroid carcinoma.Methods Forward-looking inclusion 186 patients of papillary thyroid carcinoma in our hospital from August 2016 to June 2018,there were 113 males and 73 females.All the patients were divided into two groups at random by using SPSS 17.0 software,which were numbered 1 to 186 in sequence,and the patients were divided into two groups at random.Among them,105 cases were underwent transthoracic and mammary minimally invasive endoscopic surgery (observation group),81 cases were underwent open operation (control group).Compared the three groups of patients with operation time,intraoperative blood loss,postoperative cervical autonomic activity time,postoperative hospital stay,postoperative pain score on the first day and postoperative complications and so on.The measured data were expressed by t test of group design data,the counting data were expressed byx2 test.Results There was no perioperative deaths and serious complications during perioperative in this two groups.No transmissible open operation was found in the observation group.The difference was not statistically significant in operation time and intraoperative blood loss between this two groups,[(55.83 ±4.52) min vs (56.72 ±6.28)min,t =3.158,P=0.284;(24.65 ± 8.13) ml vs (25.83 ±7.42) ml,t =4.146,P=0.173].The observation group was superior to the control group in postoperative cervical autonomic activity time,postoperative hospital stay and postoperative pain score on the first day [(1.58±0.24) dvs (2.77±0.61) d,t=7.355,P=0.020;(4.33 ±1.04) dvs (6.75 ±1.81) d,t=6.814,P=0.031;(2.15 ±0.71) scores vs (4.34 ±1.03) scores,t =6.923,P=0.026].There was no significant difference in postoperative complications (incisional infection,hypocalcemia,drinking water choking,hoarseness) between the two groups (x2 =1.674,P =0.643).The median follow-up was 10 months (monthly follow-up by telephone) and no recurrence occurred during the follow-up.Conclusion Transthoracic and mammary minimally invasive endoscopic surgery in the treatment of papillary thyroid carcinoma has the advantages of small trauma,quick recovery and high aesthetic value,which is worthy of clinical promotion.