1. Expression and role of SOCS-3 and associated cytokines in HIV/TB coinfection
Fang ZHAO ; Xiaoning LIU ; Lin CHENG ; Liumei XU ; Shaxi LI ; Kanru CAI ; Yun HE ; Hui WANG ; Yingxia LIU
Chinese Journal of Experimental and Clinical Virology 2017;31(6):515-518
Objective:
To investigate the expression levels and clinical significance of serum suppressor of cytokine signaling-3 (SOCS3) and associated cytokines in HIV/TB co-infected patients.
Methods:
The serum levels of SOCS3, IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-17 and IL-22 were quantified by using enzyme-linked immunosorbent assays (ELISA) in 50 HIV-infected patients, 48 HIV/TB co-infected patients and 50 healthy donors. Pearson correlation analysis was used to analyze the correlation between SOCS3 and other seven cytokines.
Results:
Serum levels of SOCS3 expression in HIV/TB co-infection group were significantly higher than those in HIV-infection alone and the control group. There was also significant correlation between SOCS3 and IFN-γ, IL-4, IL-6, IL-10, IL-2 in HIV/TB co-infection group.
Conclusions
These findings indicated that SOCS3 may play an important role in the immune response of patients with HIV/TB co-infection and it may be helpful in the diagnosis of HIV/TB co-infection.
2. Investigation on AIDS cognition and sexual behavior among patients with HIV/AIDS in shenzhen in 2016
Liumei XU ; Shaxi LI ; Weimei CHEN ; Fang ZHAO ; Qiaoli PENG ; Danying WENG ; Yuyao WANG ; Hui WANG
Chinese Journal of Experimental and Clinical Virology 2017;31(3):232-236
Objective:
To investigate the situations of AIDS related knowledge, sexual behavior with various partners among HIV positive patients in Shenzhen before highly active anti-retroviral therapy, and to provide evidences for health education intervention.
Methods:
Questionnaire survey and information collection were carried out among HIV positive patients, under the informed consent, during the first physical examination before highly active anti-retroviral therapy.
Results:
The overall awareness rate of AIDS knowledge was 91%, 94.46% and 80.95% respectively for homosexual and heterosexual populations, with significant difference between the two groups (