1.Study of Knowledge, Motivational Factors, and Potential Barriers Concerning Blood Donation Between Lapsed and Regular Blood Donors
Azizul Hassan ; Noorsuzana Mohd Shariff ; Siti Nadiah Abdul Kadir ; Sharifah Azdiana Tuan Din
Malaysian Journal of Medicine and Health Sciences 2023;19(No.2):20-29
Introduction: Many countries struggle to supply enough blood while maintaining their quality and safety. Increasing
the number of regular donors is expected to increase the donor pool and blood safety. Thus, this study describes
lapsed and regular blood donors’ characteristics, knowledge, motivation, and barriers concerning blood donation.
Methods: This observational cross-sectional study has adopted an assisted self-administered questionnaire, which
was distributed to blood donors at the Department of Transfusion Medicine, Hospital Sultanah Bahiyah, Kedah. A
total of 328 participants consisting of 164 lapsed and 164 regular donors were selected. Logistic regression tests
were used to determine the factors that predict lapsed donors. Results: Out of the selected 328 respondents, 54.3%
were in the 25–39 age group, 66.2% were males, and 85.1% were Malays. Most of the respondents (88.4%) showed
adequate blood donation knowledge, and 99.7% cited altruism as a motivator for blood donation. About 47.0% of
the respondents claimed they lack enough time as their donation barrier. Donors who were younger in age, had a
moderate blood donation knowledge (adjusted OR, 3.60; 95% CI, 1.34-9.64), didn’t know where to donate (adjusted
OR, 2.79; 95% CI, 1.47-5.29), lack enough time (adjusted OR, 1.83; 95% CI, 1.04-3.24), and insufficient information
about blood donation campaigns (adjusted OR, 2.19; 95% CI, 1.23-3.91) were more likely to lapse. Conclusion: Donor education, convenient time and location, and sufficient information about blood donation campaigns targeted at
young donors are critical for preventing lapsed donors, which could subsequently increase the regular donor pool.
2.Impact of Transfusion Practice on the Occurrence of Acute Transfusion Reactions in a Malaysian Hospital: A Single-centre Retrospective Study
Firdaus Che Ros ; Noorsuzana Mohd Shariff ; Siti Nadiah Abdul Kadir ; Sharifah Azdiana Tuan Din
Malaysian Journal of Medicine and Health Sciences 2021;17(No.4):87-94
Introduction: Acute transfusion reactions (ATR) are commonly reported in clinical transfusion practice, which may
result in significant morbidity and mortality. This study aims to explore the impact of transfusion practice on the
prevalence, characteristics, and associated factors of ATR at Hospital Sultanah Bahiyah, Kedah, Malaysia. Methods:
This was a retrospective study using records from haemovigilance forms of reported transfusion reactions, E-Delphyn
(blood bank system), and E-His (hospital information system). A total of 118 cases of ATR from January 1, 2015 until
December 31, 2017 were selected and analysed. For each case, a control was selected from a patient who did not
develop ATR. Results: A total of 122,215 units of whole blood and blood component transfusions have been performed
and 415 ATR were reported. The prevalence of ATR was 0.34% or one in 294 units transfused. There was a
significant association between ATR and red cell concentrate (RCC) stored for more than 14 days (adj OR = 65.29,
95% CI 9.29-458.85). The most common ATR were allergic reactions with 63 cases (53.4%), followed by febrile
non-haemolytic transfusion reactions (FNHTR) with 45 cases (38.1%). Allergic reactions were significantly associated
with female patients (p = 0.038) and the paediatrics age group (p = 0.038). Multivariate analysis revealed a
significant association between FNHTR and RCC stored more than 14 days (p = 0.002). Conclusion: The prevalence
of ATR in this hospital was low and associated with RCC stored for more than 14 days. Implementation of pre-storage
leucoreduction is recommended.
3.Haematochezia and Higher Glasgow-Blatchford Score are Predictive Factors for Higher Red Blood Cells Transfusion Units in a Hospital-based Retrospective Study
Mohd Faeiz Yusop ; Mastura Mohd Sopian ; Anita Bhagawi ; Sharifah Azdiana Tuan Din ; Hasmah Hussin
Malaysian Journal of Medicine and Health Sciences 2021;17(No.4):109-115
Introduction: The association between clinical characteristics and endoscopic profile of acute non-variceal upper
gastrointestinal bleeding (NVUGIB) patients with red blood cell (RBC) transfusion has not been well explored in
Malaysia. Therefore, a retrospective study was performed using a five-years database to analyse the factors clinically
and endoscopically for RBC transfusion. Methods: All adult NVUGIB patients who received RBC transfusion within
the study period of 2012-2017 in Putrajaya Hospital were enrolled. There were 180 patients selected by systematic
random sampling. Our composed clinical data include demography, risk factor, aetiology, presenting symptoms,
Glasgow-Blatchford Score (GBS), endoscopic findings according to Forrest Classification and number unit of RBC
transfusion. These data were analysed using Mann-Whitney U-Test, Pearson Correlation and Multiple Linear Regression
(MLR). Results: Total 180 patients, the mean age was 63.9 (SD 11.6). Their presenting symptoms were melaena
(62.8%), haematemesis (38.3%), and haematochezia (10.6%), with the cause of bleeding was gastric erosion
(65.6%), duodenitis/duodenal ulcer (26.1%), and oesophagitis (7.8%). The mean GBS score was 10.7, and the number
of RBC transfusion unit was 2.8. The Forrest Classification showed Forrest III (36.1%), Forrest IIc (22.8%), Forrest
IIb and Ib (14.4%) respectively. Pearson’s Correlation showed a strong correlation between GBS and unit of RBC
transfusion (r = 0.922, p-value <0.001). MLR analysis revealed haematochezia (p = 0.022) and higher GBS (p <0.001)
were independent factors associated with a higher number of RBC transfusion unit. Conclusion: Haematochezia and
higher GBS score were two predictive factors for a higher RBC transfusion unit in NVUGIB patients.
4.ABO Blood Group and Its Associated Factors Among Type 2 Diabetes Mellitus Patients
Sharifah Azdiana Tuan Din ; Mastura Mohd Sopian ; Nur Dalila Nabihan Ahmad Tajuddin ; Azrul Abdullah
Malaysian Journal of Medicine and Health Sciences 2022;18(No.4):62-66
Introduction: ABO blood group can be associated with chronic diseases, for example, cancer and coronary heart
disease, however it is not proven in Type 2 Diabetes Mellitus (T2DM). The aim of this study was to identify the association between the ABO blood group and disease control among T2DM patients at Kepala Batas, Penang. Methods:
Approximately two mL vials of fresh blood were collected and typed using the tube method from 129 T2DM and 132
non-diabetic (control) patients, who visited the specialist clinic. The sociodemographic characteristics of the T2DM
patients was analysed using descriptive analysis. The proportions of A, B, AB, and O blood groups among the diabetic and control patients were compared using the chi-square test. Any association between the ABO blood group
and disease control was identified using the bivariate correlation test. Results: No significant association was found
between the ABO group and T2DM patients (p = 0.152) when compared with the control group. However, blood
group B was the most frequent among T2DM patients (33.3%) compared to blood group O within the control group
(36.4%). Negative associations were observed between the ABO blood group and BMI (r = 0.098, p = 0.268), as well
as the HbA1C value (r = -0.065, p = 0.464). Conclusion: No association was found between the ABO blood group
and the associated risk factors (BMI and HbA1C). However, individuals with blood group B and risk factors, such as
older age group, obesity, and high HbA1C value (more than 7.0%), should be monitored.