Conducting polymers play important roles in tissue engineering and biomaterials. This paper introduces their syntheses and applications to medical engineering.

Direct hemoperfusion (DHP) with an adsorbent column using polymyxin B-immobilized polystyrene beads has been used to investigate the changes of hemorheology in rabbits with endotoxemia. We measured whole blood viscosity and hemotocrit before and after DHP with polymyxin B-immobilized polystyrene beads. Reduction in blood endotoxin concentration by DHP therapy positively correlated with improvement in hemorheological indexs. Our findings indicate that the amelioration in hemorheology was related directly to endotoxin removal by the adsorbent column with polymyxin B-immobilize polystyrene beads. So DHP with polymyxin B-immobilized polystyrene beads seems to be an important therapeutic strategy for endotoxemia.

Immobilization of heparin onto the surfaces of biomaterials is an effective approach for improving their anticoagulant properties and biocompatibility. In this article are reviewed the relevant principle, experimental researches and applications. Finally, a prospect for heparin immobilization is made as well.
Animals ; Anticoagulants ; chemistry ; Coated Materials, Biocompatible ; chemistry ; Heparin ; chemistry ; Humans ; Surface Properties ; Tissue Engineering

Endotoxin is an important factor which can lead to endotoxemia and complication. Accurate detection of its concentration is very useful for the diagnosis and treatment of these diseases. A piezoelectric biosensor for detecting endotoxin was developed, which was based on liquid damping effect of quartz crystal resonator. The test results showed that the maximal frequency shift of sensor is linearly dependent on the logarithm value of concentration of endotoxin (0.1 pg/m - 10 ng/ml). The time which d (deltaf)/dt(maax) appeared in frequency shift curve was also linearly dependent on the logarithm value of concentration of endotoxin (0.01 pg/ml - 10 ng/ml). The detection time was shortened and the minimal limit of detection was decreased using the second method. Thus the proposed sensor is much simpler, more precise and has more lower limit of detecting detection of endotoxin when compared with the conventional methods.
Animals ; Biosensing Techniques ; instrumentation ; Endotoxins ; analysis ; Equipment Design ; Quartz ; Rabbits

In this paper, the adsorbent properties of Polymyxin B immobilized polystyrene microbeads to remove endotoxin from plasma were studied and the factors that affected the absorption of endotoxin were discussed. The rat models of endotoxemia were established, which were used in hemoperfusion. The experiment results indicated that the novel affinity adsorbent could remove endotoxin from plasma effectively. Moreover, the results also showed that Polymyxin B immobilized polystyrene microbeads was a fine biomaterial of hemoperfusion as well as exhibited a satisfactory blood compatibility.
Adsorption ; Animals ; Endotoxemia ; blood ; therapy ; Endotoxins ; isolation & purification ; Female ; Hemoperfusion ; methods ; Polymyxin B ; Polystyrenes ; Rats ; Rats, Wistar

Objective:To explore the effect of enhanced recovery nursing based on traditional Chinese medicine nursing operation technology in the perioperative period of elderly patients with total hip arthroplasty.Methods:From January 2020 to December 2021, 90 patients with unilateral total hip arthroplasty in Wenzhou Traditional Chinese Medicine Hospital were selected by convenience sampling as research objects. The patients from January to December 2020 were taken as the control group ( n=43) , and the patients from January to December 2021 were taken as the observation group ( n=47) . The patients in the control group adopted the traditional orthopedic perioperative nursing, while the patients in the observation group received the enhanced recovery perioperative nursing based on traditional Chinese medicine nursing operation technology on the basis of the control group. The pain, postoperative recovery and complications were compared between the two groups. Results:The time of first exhaust, eating, getting out of bed and hospital stay after operation in the observation group were shorter than those in the control group, the Visual Analogue Scale (VAS) score at discharge was lower than that in the control group, and the incidence of postoperative gastrointestinal reactions and postoperative urinary retention were lower than those in the control group, with statistically significant differences ( P<0.01) . Conclusions:The enhanced recovery nursing based on traditional Chinese medicine nursing operation technology applied to elderly patients with unilateral total hip arthroplasty during perioperative period can reduce postoperative complications, pain and hospital stay, which is worthy of clinical promotion.

Objective To evaluate the efficacy of Budesonide/formoterol to control asthma under real-life conditions.Methods A muhi-center, open label, non-interventional study was conducted.Asthma control after 12 week therapy with Budesonide/formoterol was assessed by Asthma Control Questionnaire (ACQ) and modified Asthma Control Questionnaire (ACQ5).Results A total of 360 asthma patients were recruited,including 228 adult patients and 132 child patients.After 12 weeks' therapy,all the patients' medium value of ACQ was decreased significantly from 2.03 (adults 2.20, children 1.74) at baseline to 0.60 (adults 0.78, children 0.29) (P < 0.0001), and the medium value of ACQ5 was also decreased significantly from 2.4 (adults 2.24, children 1.76) at baseline to 0.47 (adults 0.62, children 0.20) (P < 0.0001).Conclusion Budesonide/formoterol is effective in asthma treatment, by which most asthma patients obtain and maintain clineal control.